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Plexiform schwannoma is a rare subtype of schwannoma. In this report, we present a case of plexiform schwannoma arising from the sciatic, tibial, and peroneal nerves. A 54-year-old man presented with a painful palpable mass extending from the left posterior thigh to the calf. Magnetic resonance imaging showed multiple bead-like nodular structures along the sciatic, tibial, and peroneal nerve pathway. The nodular lesions showed uniform signal intensity on T1-weighted imaging. On T2-weighted imaging, each nodule showed an eccentric area of relatively low signal intensity surrounded by an area of higher signal intensity and a low-intensity rim. Plexiform schwannoma or neurofibroma was considered as the preoperative diagnosis. Because of the patient's severe symptoms and strong desire for relief, tumor enucleation of the largest painful nodule was performed, and plexiform schwannoma was confirmed pathologically.

Background: Plexiform schwannomas (PSs) are rare. Here, we describe the clinical features, diagnosis, treatment, and outcome of a 17-year-old male presenting with a T1-T4 intradural extramedullary (IDEM)., Case Description: A 17-year-old male presented with back pain and pain radiating down both legs. The thoracic magnetic resonance revealed a left-sided T1-T4 IDEM mass. The patient underwent a T2-T4 laminectomy for gross total tumor excision, followed by posterior fusion. Immunohistochemical examination revealed S100 positivity, supporting the diagnosis of PS., Conclusion: IDEM PSs are rare, may be readily diagnosed with MR, and can be successfully resected., Competing Interests: There are no conflicts of interest., (Copyright: © 2024 Surgical Neurology International.)