1. Tamariscol biosynthesis in Frullania tamarisci.
- Author
-
Conart C and Simonsen HT
- Subjects
- Alkyl and Aryl Transferases chemistry, Alkyl and Aryl Transferases genetics, Alkyl and Aryl Transferases metabolism, Bridged Bicyclo Compounds chemistry, Bridged Bicyclo Compounds metabolism, Cyclopropanes chemistry, Cyclopropanes metabolism, Gas Chromatography-Mass Spectrometry, Genes, Plant genetics, Hepatophyta chemistry, Perfume chemistry, Phylogeny, Polyisoprenyl Phosphates biosynthesis, Polyisoprenyl Phosphates chemistry, Sesquiterpenes chemistry, Sesquiterpenes metabolism, Frullania chemistry, Frullania enzymology, Frullania genetics, Frullania metabolism, Phytochemicals biosynthesis, Phytochemicals chemistry
- Abstract
The liverwort Frullania tamarisci (L.) Dumort produces large amounts of terpenoids, among others the sesquiterpene alcohol tamariscol. Tamariscol has an earthy woody fragrance, and the use in perfurmes and production of it was patented in 1984. The microbial terpene synthase-like (MTPSL) enzyme FtMTPSL6 is shown to be responsible for the biosynthesis of tamariscol. FtMTPSL6 was obtained through RNA sequencing of wild growing F. tamarisci along with six other MTPSLs (FtMTPSL1-7). The biochemical activity was determined for three of them, and two others where metabolic active, but the product could not be identified. The three characterized enzymes are the tamariscol synthase (FtMTPSL6), copaene synthase (FtMTPSL1) and gurjunene synthase (FtMTPSL3). Thus, the biosynthesis of the economically attractive compound tamariscol is established, and this opens up for further exploitation of this molecule., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2025
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