21 results on '"Ponticelli, P"'
Search Results
2. Environment induced dynamical quantum phase transitions in two-qubit Rabi model
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Di Bello, Grazia, Ponticelli, Andrea, Pavan, Fabrizio, Cataudella, Vittorio, De Filippis, Giulio, de Candia, Antonio, and Perroni, Carmine Antonio
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- 2024
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Catalog
3. Environment induced dynamical quantum phase transitions in two-qubit Rabi model
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Grazia Di Bello, Andrea Ponticelli, Fabrizio Pavan, Vittorio Cataudella, Giulio De Filippis, Antonio de Candia, and Carmine Antonio Perroni
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Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
Abstract Quantum states beyond thermodynamic equilibrium represent fascinating and cutting-edge research. However, the behavior of dynamical quantum phase transitions in complex open quantum systems remains poorly understood. Here, using state-of-the-art numerical approaches, we show that by quenching the qubits-oscillator coupling in a dissipative two-qubit Rabi model, the system undergoes dynamical quantum phase transitions. These transitions are characterized by kinks in the Loschmidt echo rate function at parameter values close to a thermodynamic quantum phase transition and are associated with distinct entanglement features. The two classes of critical phenomena depend on qubit interactions and entanglement, revealing different behaviors of the critical exponent of the first kink of the Loschmidt echo for interacting versus non-interacting qubits. This research enhances our understanding of non-equilibrium quantum systems and offers potential applications in quantum sensing and metrology, as it examines how dynamical transitions can enhance the sensitivity of the Loschmidt echo to the quench parameters. more...
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- 2024
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4. Laser-based thermomechanical joining of semi-transparent thermoplastics with technical steel
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Genna, Silvio, Moretti, Patrizia, Ponticelli, Gennaro Salvatore, and Venettacci, Simone
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- 2024
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5. Assessment of local mechanical properties of laser powder bed fused aluminium alloy by non-destructive testing based on FIMEC indentation
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Vittorio Villani, Gennaro Salvatore Ponticelli, Simone Venettacci, and Stefano Guarino
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laser powder bed fusion ,non-destructive testing ,FIMEC ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Laser powder bed fusion process is a versatile metal additive manufacturing process. Although significant progress has been made so far, there is still limited large-scale adoption of this technique by the industry. The main problems are repeatability and lack of proper knowledge. In this work, an innovative and non-destructive testing methodology, based on flat-top cylinder indentation, was used to define the mechanical properties of laser powder bed fused aluminium alloy to highlight any variations induced by the combination of process parameters, for global characterization, and by the building direction, for local characterization. Results show similar or improved global mechanical properties of the laser powder bed fused specimens when compared to traditional die-casted ones. Indentation tests highlight a local dependence of properties along the building direction in favor of the upper part of the samples. more...
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- 2024
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6. Tribo-technological features of laser powder bed fusion process: scratch and wear resistance of AlSi10Mg aluminium alloy
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Danilo Guarino, Simone Venettacci, Vittorio Villani, Gennaro Salvatore Ponticelli, and Stefano Guarino
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laser powder bed fusion ,tribology ,scratch test ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Mechanical systems, regardless of their complexity, very often require that different parts must move relative to each other by sliding their surfaces, therefore appropriate tribological properties are needed. This request appears particularly evident for components fabricated through Metal Additive Manufacturing processes, due to their typical high surface roughness. In the current study, the Laser Powder Bed Fusion technique with optimized parameters is used to produce samples made of AlSi10Mg alloy. Their tribo-technological properties are investigated through progressive load scratch and dry ball-on-plate wear tests. Along with a global characterization, a local analysis has been performed to identify any variations induced by the building direction. The friction coefficient and the wear rate are generally higher than as-cast specimens. Finally, local trends suggest that the central parts of the samples average offer higher resistance to wear and scratch than the outer areas. more...
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- 2024
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7. Respiratory Syncytial Virus (RSV) and Intention to Recommend RSV Vaccination: A Cross-Sectional Survey of Cardiologists and Cardiac Nurses in Southern Italy
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Domenico Ponticelli, Lorenzo Losa, Ippazio Cosimo Antonazzo, Anna Zampella, Fabio Di Marino, Gaetano Mottola, Mara Noemi Fede, Fortuna Gallucci, Roberto Magliuolo, Antonio Rainone, Antonella Arcari, Carmine Del Giudice, and Pietro Ferrara more...
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cardiovascular disease ,cross-sectional survey ,elderly ,respiratory syncytial virus ,vaccine literacy ,Other systems of medicine ,RZ201-999 - Abstract
As respiratory syncytial virus (RSV) vaccine distribution gains traction in Europe and Italy, healthcare workers (HCWs) can strategize about vaccine promotion to increase uptake among patients at risk of RSV consequences, such cardiac patients. This cross-sectional survey investigated the knowledge about and attitude towards RSV and RSV vaccines, and the intention to recommend vaccination within a cardiological hospital in Italy. To explore factors associated with the outcomes of interest, multivariate logistic regression analyses were conducted. Of 197 invited HCWs, 78.2% returned the survey. The knowledge about market authorisation for new RSV vaccines for older adults (present in 46.9% of respondents) was significantly associated with the HCWs’ age, education, and previous update on vaccinations. HCWs with a higher educational level and those with a positive attitude towards RSV vaccines safety reported a higher attitude towards the importance of vaccinating people at risk. The willingness of recommending RSV vaccination to patients (70.5% of respondents) was more likely in HCWs who were knowledgeable about market authorisation for RSV vaccines and in physicians. This tempestive research sheds light on current factors influencing the strategies of cardiac HCWs regarding RSV vaccination. The results suggest the need for training events on the protective role of RSV vaccination in cardiac patients. more...
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- 2024
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8. Anti-C1q antibodies: a biomarker for diagnosis and management of lupus nephritis. A narrative review
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Marta Calatroni, Gabriella Moroni, Emanuele Conte, Matteo Stella, Francesco Reggiani, and Claudio Ponticelli
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systemic lupus erythematous ,lupus nephritis ,complement system ,classical complement pathway ,anti-complement autoantibodies ,C1q ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Nephritis is a frequent and severe complication of Systemic Lupus Erythematous (SLE). The clinical course of lupus nephritis (LN) is usually characterized by alternating phases of remission and exacerbation. Flares of LN can lead to deterioration of kidney function, necessitating timely diagnosis and therapy. The presence of autoantibodies against C1q (anti-C1qAb) in the sera of SLE patients has been reported in various studies. Some research suggests that the presence and changes in the titer of anti-C1qAb may be associated with the development of LN, as well as with LN activity and renal flares. However, the exact role of anti-C1qAb in LN remains a subject of debate. Despite variability in the results of published studies, anti-C1qAb hold promise as noninvasive markers for assessing LN activity in SLE patients. Measuring anti-C1qAb levels could aid in diagnosing and managing LN during periods of both inactive disease and renal flares. Nevertheless, larger controlled trials with standardized laboratory assays are necessary to further establish the utility of anti-C1qAb in predicting the reactivation and remission of LN and guiding treatment strategies. more...
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- 2024
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9. Editorial: Sensory systems of aquatic animals
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Jeremy M. Sullivan, Laure Bonnaud-Ponticelli, and Anna Di Cosmo
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aquatic animals ,audition ,olfaction ,sensory systems ,TRP channels ,vision ,Physiology ,QP1-981 - Published
- 2024
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10. Extraction Optimization of Quercus cerris L. Wood Chips: A Comparative Study between Full Factorial Design (FFD) and Artificial Neural Network (ANN)
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Maria Ponticelli, Vittorio Carlucci, Marisabel Mecca, Luigi Todaro, Luigi Milella, and Daniela Russo
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Quercus cerris L. ,wood chips ,antioxidant activity ,full factorial design ,artificial neural networking ,specialized metabolites ,Therapeutics. Pharmacology ,RM1-950 - Abstract
From a circular bio-economy perspective, biomass valorization requires the implementation of increasingly efficient extraction techniques to ensure the environmental and economic sustainability of biorefining processes. This research focuses on optimizing the specialized metabolite extraction of Turkey oak chips from Quercus cerris L. by applying a 3 levels Full Factorial Design (FFD). The goal is to obtain an extract with the highest antioxidant activity [evaluated by 1,1-diphenyl-2-picryl hydrazyl (DPPH) scavenging activity and ferric reducing antioxidant power (FRAP) assays] and specialized metabolites content [measured as total phenolic content (TPC), total flavonoid content (TFC), condensed tannin content (CTC), and hydrolysable tannins content (THC)]. With this objective, three different variables were investigated and compared: temperature (20 °C, 50 °C, 80 °C), solvents EtOH/H2O (0%, 20%, 40%), and time (3 h, 6 h, 24 h), resulting in 27 different extracts. Following the FFD analysis, the optimal extractive conditions were determined to be 80 °C, 40% EtOH/H2O, and 19.8 h. Finally, the prediction ability of FFD was compared with that of artificial neural network (ANN) for DPPH scavenging activity, FRAP, and TPC data based on the coefficient of determination (R2), mean absolute error (MAE), and root mean square error (RMSE). The results indicated that ANN predictions were more precise than FFD ones; however, both methods were useful in optimizing the extraction process as they returned comparable optimized extraction parameters. more...
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- 2024
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11. Nutraceutical Valorization of Exhausted Olive Pomace from Olea europaea L. Using Advanced Extraction Techniques
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Vittorio Carlucci, Maria Ponticelli, Daniela Russo, Fabiana Labanca, Valeria Costantino, Germana Esposito, and Luigi Milella
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Olea europaea L. ,by-products ,olive pomace ,green chemistry ,nutraceuticals ,circular economy ,Botany ,QK1-989 - Abstract
Exhausted olive pomace (EOP) represents the principal residue of olive pomace. Several studies have optimized the extraction of specialized metabolites from the EOP of Olea europaea L., but a comparison between different extractive methods has not been made. For this reason, the present investigation aims to compare four different extractive methods by using water and 15% ethanol/water as extractive solvents. Specifically, based on extract antioxidant activity, the methods compared were maceration (MAC), microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE), and Accelerated Solvent Extraction (ASE). Between these, the UAE and ASE hydroalcoholic EOP extracts were demonstrated to have the highest antioxidant activity. Subsequently, these extracts were investigated for their hypoglycemic and antiradical activity using in vitro cell-free and cell-based assays, respectively. ASE hydroalcoholic EOP extract demonstrated the greatest ability to inhibit the α-amylase enzyme and an in vitro antioxidant activity comparable to N-acetyl cysteine in HepG2 cells. UAE and ASE extracts’ phytochemical characterization was also performed, identifying seven phenolic compounds, including 3-hydroxytyrosol, tyrosol, and, for the first time, salidroside. The ASE hydroalcoholic EOP extract was the richest from a phytochemical point of view, thus confirming its major biological activity. Therefore, ASE and 15% ethanol/water may represent the best extractive method for EOP nutraceutical valorization. more...
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- 2024
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12. Comparison of KF-Based Vehicle Sideslip Estimation Logics with Increasing Complexity for a Passenger Car
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Lorenzo Ponticelli, Mario Barbaro, Geraldino Mandragora, Gianluca Pagano, and Gonçalo Sousa Torres
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vehicle state estimation ,vehicle dynamics ,extended Kalman filter ,unscented Kalman filter ,sideslip angle ,virtual sensing ,Chemical technology ,TP1-1185 - Abstract
Nowadays, control is pervasive in vehicles, and a full and accurate knowledge of vehicle states is crucial to guarantee safety levels and support the development of Advanced Driver-Assistance Systems (ADASs). In this scenario, real-time monitoring of the vehicle sideslip angle becomes fundamental, and various virtual sensing techniques based on both vehicle dynamics models and data-driven methods are widely presented in the literature. Given the need for on-board embedded device solutions in autonomous vehicles, it is mandatory to find the correct balance between estimation accuracy and the computational burden required. This work mainly presents different physical KF-based methodologies and proposes both mathematical and graphical analysis to explore the effectiveness of these solutions, all employing equal tire and vehicle simplified models. For this purpose, results are compared with accurate sensor acquisition provided by the on-track campaign on passenger vehicles; moreover, to truthfully represent the possibility of using such virtual sensing techniques in real-world scenarios, the vehicle is also equipped with low-end sensors that provide information to all the employed observers. more...
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- 2024
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13. Favipiravir vs. Deferiprone: Tautomeric, photophysical, in vitro biological studies, and binding interactions with SARS-Cov-2-MPro/ACE2
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Nikolay T. Tzvetkov, Martina I. Peeva, Maya G. Georgieva, Vera Deneva, Aneliya A. Balacheva, Ivan P. Bogdanov, Maria Ponticelli, Luigi Milella, Kiril Kirilov, Maima Matin, Hans-Georg Stammler, Atanas G. Atanasov, and Liudmil Antonov more...
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Favipiravir ,Deferiprone ,Tautomer-based drug design ,COVID-19 ,Molecular modelling ,Tautomerism ,Biotechnology ,TP248.13-248.65 - Abstract
Coronavirus disease 2019 (COVID-19) still remains the most disastrous infection continuously affecting millions of people worldwide. Herein, we performed a comparative study between the anti-influenza drug favipiravir (FAV) and the anti-thalassemia drug deferiprone (DFP) in order to examine their potential as basic scaffolds for the generation of most effective and structurally novel antivirals. To conduct the initial molecular modelling and virtual screening steps, our recently proposed single crystal X-ray diffraction (SCXRD)/HYdrogen DEssolvation (HYDE) technology platform has been used. This platform allows molecular design, interactive prioritization and virtual evaluation of newly designed molecules, simultaneously affecting two COVID-related targets, including angiotensin-converting enzyme 2 (ACE2) as a host-cellular receptor (host-based approach) and the main protease (Mpro) enzyme of the spike glycoprotein of SARS-Cov-2 (virus-based approach). Based on the molecular docking results, DFP has shown higher binding affinity (Ki HYDE values) over FAV towards both biological targets. The tautomeric, physicochemical, and biological properties of FAV and DFP have been studied both experimentally and theoretically using molecular spectroscopy (UV–VIS absorption), parallel artificial membrane permeability assay, and cell biology (PAMPA and MTT assay), as well as DFT quantum chemical calculations. According to the obtained results, the enol tautomers of both compounds are considerably more stable in different organic solvents. However, the keto tautomer of FAV was estimated to be most preferable under physiological conditions, which is in good agreement with the molecular docking studies. The isolated crystal structure of DFP is in an excellent agreement with the computation in respect of the most stable tautomer. Combined single X-ray/molecular modeling studies including HYDE analyses provided not only insights into the protein–ligand interactions within the binding site of SARS-Cov-2-ACE2 and SARS-Cov-2-Mpro, but also a valuable information regarding the most stable enol tautomeric form of DFP that contributes to its estimated higher potency against these targets. more...
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- 2024
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14. Crystal Structures, Molecular Docking and In Vitro Investigations of Two 4-Substituted 2-(5,5-dimethyl-3-styrylcyclohex-2-enylidene)malononitrile Derivatives as Potential Topoisomerase II Inhibitors
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Martina I. Peeva, Maya G. Georgieva, Aneliya A. Balacheva, Maria Ponticelli, Ivan P. Bogdanov, Tsonko Kolev, Luigi Milella, Hans-Georg Stammler, and Nikolay T. Tzvetkov
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cytotoxicity ,etoposide ,molecular docking ,styrylcyclohex-2-enylidene-malononitrile ,topoisomerase II inhibitors ,X-ray ,Crystallography ,QD901-999 - Abstract
Type II topoisomerases (TOP2s) play a key role in altering the DNA topology by transiently cleaving both strands of a DNA duplex. Therefore, increased TOP2 activity is associated with many cancers. Herein, we present the synthesis, structural characterization, virtual screening, and structural exploration, as well as evaluation of the antiproliferative effects of two new 4-substituted 2-(5,5-dimethyl-3-styrylcyclohex-2-enylidene)malononitrile derivatives with potential application in the drug design of isoform-specific TOP2 inhibitors. Both compounds 1 and 2 were verified by ESI-TOF-MS, NMR, and single-crystal X-ray diffraction (SCXRD) analysis. Furthermore, we applied our recently proposed SCXRD/HYdrogen DEsolvation (HYDE) technology platform in order to perform molecular modeling, virtual screening, and structural exploration with 1 and 2. For this purpose, we used the crystal structure of human TOP2β complexed to DNA and the anticancer drug etoposide. Moreover, we further evaluated the antiproliferative activity of 1 and 2 on human hepatocarcinoma HepG2 cells and compared the observed effects with those of the reference hTOP2β inhibitor etoposide. Based on the obtained results, compounds 1 and 2 showed a virtually higher binding affinity (Ki HYDE values) over etoposide towards hTOP2β but lower antiproliferative activity compared to those of etoposide. more...
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- 2024
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15. Ultrasound, Histomorphologic, and Immunohistochemical Analysis of a Cardiac Tumor with Increased Purkinje Cells Detected in a Canine Fetus 42 Days into Pregnancy
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Enrico Giordano, Ignazio Ponticelli, Simona Attard, Teresa Bruna Pagano, and Maria Carmela Pisu
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heart disease ,puppy heart tumor ,Purkinje cell tumor ,immunohistochemistry ,Veterinary medicine ,SF600-1100 - Abstract
A seven-year-old healthy female Chow Chow was referred for pregnancy monitoring. Ultrasonography was used to evaluate all pregnancy and fetus parameters, and they were found to be normal. During the examination of the 42 day pregnant bitch, an unusual mass was seen in a fetus’s heart. This fetus had a cardiac frequency of 273–300 beats, while the others had heart rates of 220–240 beats. Natural vaginal birth occurred at 63 days pregnant: the first two puppies were stillborn but perfectly formed, and the other three were alive and had optimal APGAR. In one of two deceased puppies, an unusual, reddish, smooth mass occupying the space in the heart was found through necroscopy. The organ was submitted for histological examination. Histopathology, immunohistochemical, and histochemical analyses all indicated a cardiac tumor with increased Purkinje cells. This type of tumor has been described in infants, swine, bearded seals, and deer but never in fetuses and neonates of dogs. To our knowledge, this is the first such case reported in veterinary medicine. more...
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- 2024
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16. Withania somnifera (L.) Dunal, a Potential Source of Phytochemicals for Treating Neurodegenerative Diseases: A Systematic Review
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Valentina Lerose, Maria Ponticelli, Nadia Benedetto, Vittorio Carlucci, Ludovica Lela, Nikolay T. Tzvetkov, and Luigi Milella
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Withania somnifera (L.) Dunal ,withanolides ,Alzheimer’s disease ,Parkinson’ s disease ,ALS disease ,Huntington’s disease ,Botany ,QK1-989 - Abstract
Withania somnifera (L.) Dunal is a medicinal plant belonging to the traditional Indian medical system, showing various therapeutic effects such as anti-cancer, anti-inflammatory, anti-microbial, anti-diabetic, and hepatoprotective activity. Of great interest is W. somnifera’s potential beneficial effect against neurodegenerative diseases, since the authorized medicinal treatments can only delay disease progression and provide symptomatic relief and are not without side effects. A systematic search of PubMed and Scopus databases was performed to identify preclinical and clinical studies focusing on the applications of W. somnifera in preventing neurodegenerative diseases. Only English articles and those containing the keywords (Withania somnifera AND “neurodegenerative diseases”, “neuroprotective effects”, “Huntington”, “Parkinson”, “Alzheimer”, “Amyotrophic Lateral Sclerosis”, “neurological disorders”) in the title or abstract were considered. Reviews, editorials, letters, meta-analyses, conference papers, short surveys, and book chapters were not considered. Selected articles were grouped by pathologies and summarized, considering the mechanism of action. The quality assessment and the risk of bias were performed using the Cochrane Handbook for Systematic Reviews of Interventions checklist. This review uses a systematic approach to summarize the results from 60 investigations to highlight the potential role of W. somnifera and its specialized metabolites in treating or preventing neurodegenerative diseases. more...
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- 2024
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17. Knowledge, Attitudes and Practices Survey of Recombinant Zoster Vaccine among Cardiologists and Cardiac Nurses in Italy
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Domenico Ponticelli, Ippazio Cosimo Antonazzo, Lorenzo Losa, Anna Zampella, Fabio Di Marino, Gaetano Mottola, Mara Noemi Fede, Fortuna Gallucci, Roberto Magliuolo, Antonio Rainone, Carmine Del Giudice, Antonella Arcari, and Pietro Ferrara more...
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cardiology ,herpes zoster ,recombinant zoster vaccine ,vaccine literacy ,Medicine (General) ,R5-920 - Abstract
Background and Objectives: Cardiac patients are particularly at risk of herpes zoster (HZ), which is associated with a higher risk of major cardiovascular events. This research aimed to analyze the knowledge, attitudes and practices towards recombinant zoster vaccine (RZV) among cardiac healthcare professionals (HPs). Materials and Methods: A cross-sectional survey was conducted in a cardiological hospital in Italy. Multivariate regression models were built to identify factors associated with the outcomes of interest. Results: The response rate was 78.2% (154/197). Overall, age > 50 years and immunosuppression were recognized as risk factors for HZ by 38.3% and 75.3% of respondents, respectively. Regarding RZV, 29.1% of the HPs correctly responded about its schedule and 57.6% about the possibility of administration in immunocompromised individuals. This knowledge was significantly higher in HPs with a higher educational level (odds ratio (OR) = 4.42; 95%CI 1.70–11.47), in those who knew that HZ could cause postherpetic neuralgia (OR = 2.56; 95%CI 1.05–6.25) or major cardiovascular events (OR = 4.23; 95%CI 1.50–11.91), in those who had participated in professional updates on vaccinations (OR = 3.86; 95%CI 1.51–9.87) and in those who stated the need for further information about the RZV (OR = 6.43; 95%CI 1.42–29.98). Younger HPs (coefficient (β) = −0.02; 95%CI −0.04–−0.01), those with a positive attitude toward RZV safety (β = 2.92; 95%CI 2.49–3.36) and those who had previously cared for patients with HZ (β = 0.45; 95%CI 0.03–0.88) reported a more positive attitude toward RZV effectiveness. The practice of recommending vaccination was more prevalent in younger HPs (OR = 0.94; 95%CI 0.89–0.99), in those who had a master’s degree or higher education (OR = 7.21; 95%CI 1.44–36.08), in those with more positive attitudes toward RZV effectiveness (OR = 7.17; 95%CI 1.71–30.03) and in HPs who had already recommended the vaccine to patients in the past (OR = 4.03; 95%CI 1.08–14.96). Conclusions: Despite being a single-center study, our research brings attention to factors that currently impact cardiac HPs’ approaches to RZV. The findings indicate potential measures to enhance HPs’ awareness and practices, ultimately aiming to improve vaccination adherence and reduce the burden associated with HZ. more...
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- 2024
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18. Harnessing Cyanobacteria’s Bioactive Potential: A Sustainable Strategy for Antioxidant Production
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Teresa De Rosa, Maria Ponticelli, Roberta Teta, Vittorio Carlucci, Luigi Milella, Germana Esposito, and Valeria Costantino
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cyanobacteria ,Anabaena ,natural products ,mass spectrometry ,molecular network ,antioxidant ,Biology (General) ,QH301-705.5 - Abstract
Unsaturated diacylglycerols are a class of antioxidant compounds with the potential to positively impact human health. Their ability to combat oxidative stress through radical scavenger activity underscores their significance in the context of preventive and therapeutic strategies. In this paper we highlight the role of Anabaena flos-aquae as a producer of unsaturated mono and diacylglycerols, and then demonstrate the antioxidant activity of its methanolic extract, which has as its main components a variety of acylglycerol analogues. This finding was revealed using a sustainable strategy in which the One Strain Many Compounds (OSMAC) cultivation in microscale was coupled with a bioinformatic approach to analyze a large dataset of mass spectrometry data using the molecular networking analyses. This strategy reduces time and costs, avoiding long and expensive steps of purification and obtaining informative data on the metabolic composition of the extracts. This study highlights the role of Anabaena as a sustainable and green source of novel bioactive compounds. more...
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- 2024
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19. Immune-mediating and immunosuppressive pharmacotherapies for proliferative lupus nephritis
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Moroni, Gabriella, Reggiani, Francesco, and Ponticelli, Claudio
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ABSTRACTIntroductionProliferative lupus nephritis is a common and severe complication of systemic lupus erythematosus. Affected patients are at an increased risk of developing chronic kidney disease, end-stage kidney disease, and extra-renal comorbidities. In recent years, the prognosis for patients with proliferative lupus nephritis has improved thanks to advancements in management regimens. Despite these advances, lupus nephritis continues to present therapeutic complexities and unmet needs.Areas coveredResearch was conducted across major databases to identify the most relevant articles pertaining to immune-mediating and immunosuppressive therapies in lupus nephritis.Expert opinionThe prognosis for patients with proliferative lupus nephritis remains severe. Some drugs used in this disease may be unable to control activity, and most of them have a low therapeutic index and may cause severe and life-threatening side effects. Nonetheless, better management of traditional drugs and the introduction of novel therapies have improved renal prognosis and reduced local and systemic adverse events in patients with proliferative lupus nephritis. more...
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- 2024
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20. Insight into the Interaction of Humulus lupulus L. Specialized Metabolites and Gastrointestinal Bitter Taste Receptors: In Vitro Study in STC‑1 Cells and Molecular Docking.
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Lela, Ludovica, Ponticelli, Maria, Carlucci, Vittorio, Stevens, Jan F., Faraone, Immacolata, Tzvetkov, Nikolay T., and Milella, Luigi
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- 2024
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21. Insight into the Interaction of Humulus lupulusL. Specialized Metabolites and Gastrointestinal Bitter Taste Receptors: In VitroStudy in STC-1 Cells and Molecular Docking
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Lela, Ludovica, Ponticelli, Maria, Carlucci, Vittorio, Stevens, Jan F., Faraone, Immacolata, Tzvetkov, Nikolay T., and Milella, Luigi
- Abstract
Bitter taste receptors, also known as taste 2 receptors (T2R), are expressed throughout the body and are involved in regulating different physiological processes. T2R expression in the intestinal tract regulates orexigenic and anorexigenic peptide secretion, thus becoming potential a potential target for controlling food intake and the prevalence of obesity and overweight. The present study aims to investigate the implication of hop bitter compounds such as α-acids, β-acids, and xanthohumol in the secretion of anorexigenic hormones and T2R expression in intestinal STC-1 cells. The tested bitter compounds induced the secretion of the anorexigenic hormones glucagon-like peptide 1 and cholecystokinin concurrently with a selective increase of murine Tas2rexpression. Xanthohumol and α-acids selectively increase Tas2r138 and Tas2r130–Tas2r138 expression, respectively, in STC-1 cells, while β-acids increased the expression of all bitter receptors studied, including Tas2r119, Tas2r105, Tas2r138, Tas2r120, and Tas2r130. Increased intracellular calcium levels confirmed this activity. As all investigated bitter molecules increased Tas2r138 expression, computational studies were performed on Tas2r138 and its human orthologue T2R38 for the first time. Molecular docking experiments showed that all molecules might be able to bind both bitter receptors, providing an excellent basis for applying hop bitter molecules as lead compounds to further design gastrointestinal-permeable T2R agonists. more...
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- 2024
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