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Background Direct endoluminal imaging, such as with our previously described microangioscope, is an emerging adjunct in endovascular cerebral aneurysm management that enables clinicians to delineate between thrombi and visualize neoepithelialization after stent placement with high resolution. The present study sought to study flow diversion in vivo under direct endoluminal imaging, and to validate our findings with histopathology. Methods In a rabbit model, we implanted each left common carotid artery with a shielded flow diverter (FD) (Medtronic Pipeline Vantage) and nonshielded FD (Medtronic Pipeline Flex) in the right common carotid artery. We studied 9 animals in 3 groups: (1) no periprocedural antiplatelet therapy, (2) aspirin 81 mg daily, and (3) aspirin 81 mg and clopidogrel 75 mg daily. FD thrombosis, stenosis, malapposition, and neoepithelialization were all evaluated by diagnostic cerebral angiography and microangioscopy after 30 days. Diagnostic cerebral angiography and angioscopic video were analyzed by independent evaluators and compared with histopathologic analysis. Results In the aspirin and dual antiplatelet therapy groups, there were no significant observed differences in stent thrombosis, stenosis, malapposition, or neoepithelialization between the shielded and non‐shielded FD groups. There was significantly more thrombus formation in Group 1. Neointimal thickness as measured by the microangioscope was highly correlated with histology (r = 0.72; P = 0.016). Interrater agreement of microangioscope videos was highest for FD thrombosis and stenosis. Conclusion In‐stent thrombosis, stenosis, malapposition, and neopithelialization demonstrated no significant difference between shielded and non‐shielded FDs. Microangioscopy measurements for neointimal thickness were highly correlated with pathology and may be a helpful adjunct to diagnostic cerebral angiography in FD follow‐up.

The relentless growth of modern Machine Learning models has spurred the adoption of sparsification techniques to simplify their architectures and reduce the computational demands. Network pruning has demonstrated success in maintaining original network accuracy while shedding significant portions of the original weights. However, leveraging this sparsity efficiently remains challenging due to computational irregularities, particularly in GPU kernels. A new trend of template-based GPU kernels for semi-structured sparsity shows promise in efficiency but lacks autotuning capabilities to adapt to input dynamics, often underperforming in scenarios where they have not been meticulously hand-tuned. We present STuning-DL, the first pruning-aware autotuner for third-party template-based implementations enabling efficient optimization of sparse kernels for Deep Learning, spanning from high-level aspects (CUDA C++ level) down to GPU-native instructions specifics (assembly-level). STuning-DL tunes and optimizes at run-time sparse kernels’ performance for each input problem, yielding speedups of up to $5.42\times $ on NVIDIA T4-16GB and up to $3.6\times $ on NVIDIA A100-40GB GPU in sparse matrices from real world models compared to existing heuristics from sparse libraries like cuSparse and cuSparseLt.

Air pollution is recognized by the World Health Organization as the major environmental threat; therefore, air quality is constantly being monitored by monitoring stations. However, the most common atmospheric pollutants being monitored do not include pollen. Among the reasons for the lack of pollen control is that there are different types and sizes of pollen. The largest particles commonly being monitored by air monitoring stations have a maximum aerodynamic diameter of 10 microns, while the aerodynamic diameter of most pollen grains is known to range from 10 to 100 microns. For this reason, most pollen is not being detected by air monitoring stations. For the patents found in a literature review, monitoring pollen concentration in the air requires the discrimination of pollen grains from particulate matter of a similar size, as well as the identification of the type of pollen grains detected, since different pollen types may produce different effects, such as allergic reactions, asthma, and lung cancer, in exposed people. In this work, 15 patent documents regarding pollen monitoring were identified and reviewed using three search engines: Google Patents, WIPO’s PatentScope, and the United States Patent and Trademark Office (USPTO) database. The extracted data from the patents included whether they differentiate pollen type, pollen size, and sensor type and whether they provide real-time data. The results show that 93.33% of the patents identify pollen type, while 80% of the patents identify pollen size. Most of the patents use light-scattering and image sensors and use image processing techniques to analyze particles. Furthermore, 40% of the patents were found to implement artificial intelligence. Further, it was found that only nine patents provide real-time data, which is an important feature of an air monitoring system.

Air pollution is caused by the presence of polluting elements. Ozone (O3), carbon monoxide (CO), carbon dioxide (CO2), nitrogen dioxide (NO2), sulfur dioxide (SO2), and particulate matter (PM) are the most controlled gasses because they can be released into the atmosphere naturally or as a result of human activity, which affects air quality and causes disease and premature death in exposed people. Depending on the substance being measured, ambient air monitors have different types of air quality sensors. In recent years, there has been a growing interest in designing drones as mobile sensors for monitoring air pollution. Therefore, the objective of this paper is to provide a comprehensive patent review to gain insight into the proprietary technologies currently used in drones used to monitor outdoor air pollution. Patent searches were conducted using three different patent search engines: Google Patents, WIPO’s Patentscope, and the United States Patent and Trademark Office (USPTO). The analysis of each patent consists of extracting data that supply information regarding the type of drone, sensor, or equipment for measuring PM, the lack or presence of a cyclone separator, and the ability to process the turbulence generated by the drone’s propellers. A total of 1473 patent documents were retrieved using the search engine. However, only 13 met the inclusion criteria, including patent documents reporting drone designs for outdoor air pollution monitoring. Therefore, was found that most patents fall under class G01N (measurement; testing) according to the International Patents Classification, where the most common sensors and devices are infrared or visible light cameras, cleaning devices, and GPS tracking devices. The most common tasks performed by drones are air pollution monitoring, assessment, and control. These categories cover different aspects of the air pollution management cycle and are essential to effectively address this environmental problem.

To determine the optimal germination temperature for Pyrus ussuriensis seeds and whether they experienced the phenomenon of thermodormancy and its inciting factors, several germination tests were conducted using non-dormant P. ussuriensis seeds for comparison. The results showed that the highest germination rate of P. ussuriensis seeds was reached at a constant temperature of 5 °C and variable temperature (night/day) of 5 °C/10 °C. Constant temperatures of 25 °C for three days induced thermodormancy, triggering significant drops in seeding emergence. Thermodormancy was related to the inhibitory effect of endogenous substances in the seed coat and an elevated abscisic acid concentration. The embryo, by contrast, remained non-dormant. Thermodormant and non-dormant seed embryos showed higher germination rates than dormant seed embryos when applied exogenous abscisic acid and gibberellic acid. We found that P. ussuriensis seeds showed thermodormancy; thus, during early spring sowing, high temperatures should be avoided to prevent low seed germination capacity. Additionally, applying exogenous gibberellic acid, shading and increasing soil moisture can be helpful to enhance the species seed germination.

Changes in vapour pressure deficit can lead to the depletion and replenishment of stem water pools to buffer water potential variations in the xylem. Yet, the precise velocity at which stem water pools track environmental cues remains poorly explored. Nine eucalyptus seedlings grown in a glasshouse experienced high-frequency environmental oscillations and their stem radial variations (ΔR) were monitored at a 30-s temporal resolution in upper and lower stem locations and on the bark and xylem. The stem ΔR response to vapour pressure deficit changes was nearly instantaneous (<1 min), while temperature lagged behind stem ΔR. No temporal differences in the stem ΔR response were observed between locations. Punctual gravimetric measurements confirmed the synchrony between transpiration and stem ΔR dynamics. These results indicate (i) that stem-stored water can respond to the atmospheric evaporative demand much faster than commonly assumed and (ii) that the origin of the water released to the transpiration stream seems critical in determining time lags in stem water pool dynamics. Near-zero time lags may be explained by the high elasticity of eucalyptus woody tissues and the predominant water use from the xylem, circumventing the hydraulic radial barriers to water flow from/to the outer tissues. [ABSTRACT FROM AUTHOR]

Despite the ever-growing presence of Black immigrant college students in the United States, little is known about their unique campus experiences or their mental health outcomes as it relates to psychopolitical determinants of well-being. This qualitative study aimed to explore the unique psychopolitical experiences of 14, first- and second-generation Black immigrant college students attending predominately White institutions in the United States. Using the theoretical frameworks of critical race theory, intersectionality, and psychopolitical validity to guide our study, a phenomenological approach uncovered six themes and 11 subthemes: (1) collective well-being, (2) relational well-being, (3) individual well-being (purpose; health and wellness; critical consciousness), (4) collective suffering (neocolonialism, oppressive policies, and political violence; institutional oppression; barriers to mental health care), (5) relational suffering (implicit racial bias, stereotypes, and microaggressions; violence and brutality), and (6) individual suffering (ethno-racial trauma; isolation; school-related stress). We highlight implications for practitioners working with Black immigrant college students such as providing culturally responsive mental health care and advocating for decolonized and antiracist trainings at predominately White institutions. Public Significance Statement: Little is known about the intersectional experiences of Black immigrant college students attending predominately White institutions in the United States. The present study sheds light on the experiences of psychopolitical well-being and psychopolitical suffering that these students experiences as they navigate higher education. [ABSTRACT FROM AUTHOR]

ABSTRACT Stem growth responses to soil and atmospheric drought are critical to forecasting the tree carbon sink strength. Yet, responses of drought‐prone forests remain uncertain despite global aridification trends. Stem diameter variations at an hourly resolution were monitored in five Mediterranean tree species from a mesic and a xeric site for 6 and 12 years. Stem growth and dehydration responses to soil (REW) and atmospheric (VPD) drought were explored at different timescales. Annually, growth was determined by the number of growing days and hours. Seasonally, growth was bimodal (autumn growth ≈ 8%–18% of annual growth), varying among species and sites across the hydrometeorological space, while dehydration consistently responded to REW. Sub‐daily, substantial growth occurred during daytime, with nighttime‐to‐daytime ratios ranging between 1.2 and 3.5 (Arbutus unedo ≈ Quercus faginea < Quercus ilex < Pinus halepensis in the mesic site, and Juniperus thurifera < P. halepensis in the xeric site). Overall, time windows favourable for growth were limited by soil (rather than atmospheric) drought, modulating annual and seasonal growth in Mediterranean species, and stems maintained non‐negligible growth during daytime. These patterns contrast with observations from wetter or cooler biomes, demonstrating the growth plasticity of drought‐prone species to more arid climate conditions. [ABSTRACT FROM AUTHOR]

Objective: Research has documented the importance of parental support as a protective factor against depressive symptoms among lesbian, gay, bisexual, transgender, and queer (LGBTQ) youth. In this study, we assessed the relations between LGBTQ-specific parental support and depressive symptoms. Method: Participants were 6,837 LGBTQ youth (ages 13–17) with diverse racial and ethnic, gender, and sexual identities. Main effect and moderation analyses examined interactions between LGBTQ-specific parental support with demographic variables on depressive symptoms, considering demographics as moderators. Results: We found that participants of color reported less LGBTQ-specific parental support than their White counterparts, that transgender and genderqueer participants reported less LGBTQ-specific parental support than their cisgender counterparts, and that non-monosexual participants reported less LGBTQ-specific parental support than their monosexual counterparts. Disparities in depressive symptoms were found for individuals who identified as Native American and Latinx, non-monosexual, and transgender and genderqueer, such that these groups reported higher levels of depressive symptoms. Further, we found a significant interaction between LGBTQ-specific parental support and ethnicity, with LGBTQ-specific parental support being less strongly associated with participants who identified as Latinx compared to those who did not identify as Latinx. We also found a significant interaction between LGBTQ-specific parental support and gender identity, with LGBTQ-specific parental support being more strongly related to depressive symptoms among participants who did not identify as boys compared to cisgender boys. Discussion: We discuss how to assess the impact of interlocking systems of oppression when working with LGBTQ youth and their parental figures. [ABSTRACT FROM AUTHOR]

Parental support is crucial in the well-being of transgender and gender diverse (TGD) youth. Research shows that parents of TGD youth often experience stigma and negative mental health outcomes as a result of being exposed to cissexist settings as they advocate and seek services for their child. Yet, there is a lack of research on the experiences of parents of TGD youth in the United States. This study explores the reported hopes of 990 parents (Mage = 48.6 years; SD = 6.7; 88.1% White; 67.3% heterosexual; 89.4% cisgender women) of TGD youth for their children (youth ages 3–18 years) in the United States. Radical hope framework is applied to unpack narratives of hopes by parents of TGD youth as a critical component of resistance and motivation toward healing from oppression. For this study, the following open-ended question was analyzed using thematic analysis: What is your greatest hope for your child? Four main themes and 11 subthemes of parental hopes emerged: (1) living authentically (freely expressing themselves, developing self-love, living a happy and normal life), (2) interpersonal connections (finding community, building social networks and friendships, developing romantic relationships, building their own family, and loved by others), (3) meeting life milestones (career and employment, achieving goals and dreams, and becoming an advocate), and (4) acceptance by society. We provide clinical recommendations grounded on the tenets of radical hope such as collective ways in which parents of TGD youth can engage in both resisting systemic oppression and building strong loving relationships with their child. [ABSTRACT FROM AUTHOR]

Objective: The purpose of this study is to assess cleft rhinoplasty terminology across phases of growth. Design/Setting: A systematic review was performed on cleft rhinoplasty publications over 20 years. Interventions: Studies were categorized by age at surgical intervention: infant (<1 year); immature (1 to 14 years); mature (>15 years). Main Outcome Measures: Collected data included terminology used and surgical techniques. Results: The 288 studies included demonstrated a wide range of terminology. In the infant group, 51/54 studies used the term "primary." In the immature group, 7/18 studies used the term "primary," 3/18 used "secondary." In the mature group, 2/33 studies used the term "primary," 16/33 used "secondary," 2/33 used "definitive," 5/33 used terms such as "mature," "adult," and "late," and 8/33 did not use terminology. Surgical technique assessment demonstrated: cleft rhinoplasty at infancy used nostril rim or no nasal incision, immature rhinoplasty used closed and open rhinoplasty incisions; and mature rhinoplasty used a majority of open rhinoplasty. Infant and immature cleft rhinoplasty incorporated septal harvest or spur removal in <10% of cases, whereas these procedures were common in mature rhinoplasty. No studies in infants or immature patients used osteotomies or septal grafts, common techniques in mature rhinoplasty. Conclusions: Current terminology for cleft rhinoplasty is varied and inconsistently applied across stages of facial development. However, cleft rhinoplasty performed at infancy, childhood, and facial maturity are surgically distinct procedures. The authors recommend the terminology "infant," "immature," and "mature" cleft rhinoplasty to accurately describe this procedure within the context of skeletal growth. [ABSTRACT FROM AUTHOR]

Introduction: Postoperative management following primary cleft lip repair varies across institutions, cleft care teams, and individual surgeons. Postoperative precautions employed after cleft lip repair include dietary restrictions, pacifier limitations, and immobilization, with arm restraints long being used. Yet, restraint distress has led to the exploration of other forms of immobilization. Thus, this study aims to assess cleft lip scar quality and complication rates after postoperative immobilization with arm restraints versus hand mittens. Methods: A retrospective review of patients with unilateral cleft who underwent primary repair with the senior surgeon was done. Data on demographics, surgical characteristics, and immobilization utilized were gathered. A survey with pictures of postoperative scars were sent to laypeople who assessed scar quality with Modified Scar-Rating Scale scores for surface appearance, height, and color of the scar tissue. Statistical analysis was carried out for significance. Results: Twenty-eight patients with a unilateral cleft underwent arm restraints after primary lip repair, and twenty-seven utilized mittens. In total, 42 medical students completed the scar assessment. Photographs were taken an average of 23.9 (±5.8) and 28.2 (±11.9) months postoperatively in the restraint and mitten groups, respectively (p = 0.239). There were no statistically significant differences in scores between scar surface, height, color, or overall scar appearance. Complication rates were also similar between groups. Conclusions: Arm restraints appear to have no additional benefit relative to scar quality, as compared to mittens. Considering the arm restraints' burden of care, mittens should be considered as a measure to protect the lip after primary repair. [ABSTRACT FROM AUTHOR]

Background: Socio-economic status, living environments, and race have been implicated in the development of different congenital abnormalities. As orofacial clefting is the most common anomaly affecting the face, an understanding of its prevalence in the United States and its relationship with different determinants of health is paramount. Therefore, the purpose of this study is to determine the modern prevalence of oral–facial clefting in the United States and its association with different social determinants of health. Methods: Utilizing Epic Cosmos, data from approximately 180 US institutions were queried. Patients born between November 2012 and November 2022 were included. Eight orofacial clefting (OC) cohorts were identified. The Social Vulnerability Index (SVI) was used to assess social determinants of health. Results: Of the 15,697,366 patients identified, 31,216 were diagnosed with OC, resulting in a prevalence of 19.9 (95% CI: 19.7–20.1) per 10,000 live births. OC prevalence was highest among Asian (27.5 CI: 26.2–28.8) and Native American (32.8 CI: 30.4–35.2) patients and lowest among Black patients (12.96 CI: 12.5–13.4). Male and Hispanic patients exhibited higher OC prevalence than female and non-Hispanic patients. No significant differences were found among metropolitan (20.23/10,000), micropolitan (20.18/10,000), and rural populations (20.02/10,000). SVI data demonstrated that OC prevalence was positively associated with the percentage of the population below the poverty line and negatively associated with the proportion of minority language speakers. Conclusions: This study examined the largest US cohort of OC patients to date to define contemporary US prevalence, reporting a marginally higher rate than previous estimates. Multiple social determinants of health were found to be associated with OC prevalence, underscoring the importance of holistic prenatal care. These data may inform clinicians about screening and counseling of expectant families based on socio-economic factors and direct future research as it identifies potential risk factors and provides prevalence data, both of which are useful in addressing common questions related to screening and counseling. [ABSTRACT FROM AUTHOR]

Introduction: Oftentimes as result of racism, cissexism, and heterosexism, many Latinx and sexual and gender minority (SGM) youth are victims of sexual harassment, sexual assault, and violence. These experiences of victimization are in part related to increased negative mental health outcomes such as decreased self‐esteem. Some research links LGBTQ‐specific parental support to mental health outcomes among Latinx SGM youth, yet, no research has explored the role of LGBTQ‐specific parental support with self‐esteem among Latinx SGM youth. Methods: In a sample of 1,012 Latinx SGM youth (ages 13–17), we assessed: (a) associations between sexual harassment, sexual assault, and violence and self‐esteem, (b) association between LGBTQ‐specific parental support and self‐esteem, and (c) whether LGBTQ‐specific parental support moderated the relation between sexual harassment, sexual assault, and violence and self‐esteem. Main effect and moderation analyses examined interactions between LGBTQ‐specific parental support with sexual harassment, sexual assault, and violence on self‐esteem. Results: Latinx SGM youth experienced low levels of LGBTQ‐specific parental support and various degrees of sexual harassment, sexual assault, and violence. Also, transgender and nonbinary/genderqueer Latinx youth experienced lower self‐esteem than their Latinx cisgender counterparts. Increased LGBTQ‐specific parental support was related to increased self‐esteem. We also identified a significant interaction between sexual harassment, sexual assault, and violence and LGBTQ‐specific parental support, such that parental support was more protective at low levels rather than high levels of sexual harassment, sexual assault, and violence among Latinx SGM youth. Conclusions: Findings add to a growing body of research about the importance of LGBTQ‐specific parental support for Latinx SGM youth, and the need to examine culturally appropriate approaches to understand parent‐child relationship among these communities. [ABSTRACT FROM AUTHOR]

The author reflects on his experience as the first Latino professor hired to a tenure-track faculty position at the University of Denver Sturm College of Law in Denver, Colorado. Topics discussed include the impact of Critical Race Theory and Latina/o Critical Legal Theory on him as a scholar and educator, and the value of having a safe environment to explore critical race scholarship.

The study aimed to determine the study feasibility of a weekly virtual community-based choral singing program and to explore the impact of weekly choral singing on resilience, anxiety, and benefit finding in cancer survivors. Six participants were recruited from the Survivorship Choir (SC), led by a board-certified music therapist and affiliated with a cancer center. Study participants attended their standard 90-minute rehearsals, which were conducted virtually because of COVID-19 pandemic restrictions. Researchers followed participants over eight weeks, collecting data at weeks one and eight. Five self-report instruments were used and included a researcher-designed Demographic Form. The Connor-Davidson Resilience Scale (CD-RISC-10) is a 10-item questionnaire assessing participants' resilience. The PROMIS: Emotional Distress-Anxiety Scale measured participants' anxiety levels, and the Carver Benefit Finding Scale assessed participants' benefit finding levels. The participant Feedback Form, designed by the researchers, assessed the study's feasibility and effectiveness. High attendance and completion rates demonstrated the study's feasibility. Choral singing led to a statistically significant increase in resilience (W = 0.00, p =.036, r rb = -1.00) between baseline (M = 28.33, SD = 7.20) and week 8 (M = 33.83, SD = 4.88), demonstrating a large effect. While not significant, anxiety and benefit finding trended in a desirable direction with large effects. The present study format was feasible during the COVID-19 pandemic. The study showed that community-based choral singing, even in a virtual format, may positively affect cancer survivorship by increasing resilience and benefit finding and alleviating anxiety. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study was to evaluate the outcomes of orthognathic surgery (OGS) in patients with craniofacial microsomia (CFM) who had previously undergone mandibular distraction osteogenesis (MDO). Design: A retrospective cohort study was performed including all patients with CFM who were treated with OGS at a single institution between 1996 and 2019. The clinical records, operative reports, and cone beam computed tomography (CBCT) scans were reviewed. CBCT data before OGS (T1), immediately after OGS (T2), and at long-term follow-up (T3) were analyzed using Dolphin three-dimensional software to measure the occlusal cant and chin point deviation. Results: The study included 12 patients with CFM who underwent OGS (6 underwent OGS without MDO and 6 underwent OGS after MDO). There was a statistically significant improvement in occlusal cant and chin point deviation in both groups postoperatively. Occlusal cant relapsed by a mean of 0.6° (standard deviation [SD] 1.1°) in the patients who had OGS alone compared with 0.7° (SD 1.2°) in the patients who had OGS after MDO (P =.745) between T2 and T3. There was no statistically significant difference in chin point relapse between patients who had OGS alone compared with those who had OGS after MDO (0.1 mm [SD 2.5mm] vs 0.7mm [SD 2.2mm]; P =.808). Conclusions: Within the limitations of this study, these findings suggest that OGS after MDO in patients with CFM can produce stable results. [ABSTRACT FROM AUTHOR]

Prior studies indicate that anti-LGBTQ+ legislation has negative consequences for the well-being of LGBTQ+ people, their families, and their communities. In July of 2022, Florida's Parental Rights in Education Act, also called the "Don't Say Gay" bill, was signed into law. The law aimed to limit K–3 instruction and discussion related to sexuality and gender, encompassing LGBTQ+ identities. The present study surveyed 113 LGBTQ+ parents in Florida about their experiences and perceptions related to the Parental Rights in Education Act. Qualitative content analysis revealed five major themes and 14 subthemes, including: (a) living in Florida: pros and cons; (b) initial reactions to the law; (c) feelings over time; (d) coping with worries; and (e) beyond "coping": considering the future and possibility of relocation. Recommendations center on the need for counseling psychologists to use their privilege and training to advocate on behalf of LGBTQ+ parents, families and others impacted by this legislation. [ABSTRACT FROM AUTHOR]