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Since there is currently no cure for Alzheimer's disease (AD), it is important to develop methods that could contribute to its diagnosis and propose new therapeutic approaches for its treatment. Positron emission tomography (PET) is a medical imaging technique that can be used to diagnose Alzheimer's disease, as some radiotracers have been developed to detect amyloid plaques, one of the hallmarks of the disease. However, the radiotracers already used for the diagnosis of AD have a low half-life, which limits their use over the time and requires the presence of a cyclotron close to the examination site. The use of copper complexes could be a good alternative for the development of new radiotracers, since they can be used in PET imaging and have a longer half-life than the other radiotracers already used for AD diagnosis. In this context, the aim of our work is to synthesize copper complexes that could be used as PET radiotracers able to cross the blood brain barrier and detecting amyloid plaques. A first complex has already been synthesized. The physicochemical studies performed indicate that this complex seem to be thermodynamically stable. In addition, cytotoxicity tests on human neuronal cells and labeling tests on brain sections from Alzheimer's patients show promising results. We are also proposing the development of a new copper complex for tau PET imaging. [ABSTRACT FROM AUTHOR]