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Biomaterials like chitosan, hydroxyapatite have been used in biomedical and pharmaceutical field, due to its valuable biochemical and physiological properties. In current work firstly our group has isolated a polysaccharide chitosan along with hydroxyapatite biomaterial from the same source by varying the process condition via greener approach. We have adapted greener approach for the isolation of chitosan within a short period of time and this is the very first report for the isolation of both chitosan and hydroxyapatite simultaneously from the same waste edible garden snail shells. Both these materials were thoroughly characterized by using UV, FT-IR, SEM techniques. Among synthetic colourants, congo red dye is recognized as carcinogens, which are usually used in the textile manufacturing. Interestingly, one of our biomaterial hydroxyapatite has shown good selectivity towards Congo red dye. The sensitivity range was obtained from 10 to 100 μM within the LOD of 101.52 nM. The developed sensor has been tested for various industrial effluents and shown good agreement with our results. Meanwhile these chitosan and hydroxyapatite have also been used as capping agent for the preparation of stable gold nanoparticles., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)

As an important biomarker for renal related diseases, detection of urea is playing a vital role in human biofluids on clinical diagnosis concern. In this work, a synthetic salicyaldehyde based imine fluorophore was synthesized using sonication method and conjugated with urease which was used as fluorescent biosensor for the detection of urea in serum samples. This enzyme based biosensor has shown a good selectivity and sensitivity towards urea with the linear range from 2 to 80 mM and the detection limit of 73 µM. The sensing response obtain is highly agreeing with existing analytical technique for urea detection which strongly recommends this biosensor for clinical application., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)