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Smooth and curved microstructural topologies found in nature—from soap films to trabecular bone—have inspired several mimetic design spaces for architected metamaterials and bio‐scaffolds. However, the design approaches so far are ad hoc, raising the challenge: how to systematically and efficiently inverse design such artificial microstructures with targeted topological features? Herein, surface curvature is explored as a design modality and a deep learning framework is presented to produce topologies with as‐desired curvature profiles. The inverse design framework can generalize to diverse topological features such as tubular, membranous, and particulate features. Moreover, successful generalization beyond both the design and data space is demonstrated by inverse designing topologies that mimic the curvature profile of trabecular bone, spinodoid topologies, and periodic nodal surfaces for application in bio‐scaffolds and implants. Lastly, curvature and mechanics are bridged by showing how topological curvature can be designed to promote mechanically beneficial stretching‐dominated deformation over bending‐dominated deformation.

Poly(L-lactic acid) (PLLA), a biodegradable polymer from plant sources, is widely employed in biomedical applications for its biocompatibility and versatile mechanical properties. However, comprehending its phase behavior in various solvents poses a challenge for broader applications. In this study, the phase behavior of the polymer was investigated in various solvent and cosolvent media and combinations at a wide range of temperatures and pressures to gain insight into the polymer properties. PLLA of varying intrinsic viscosity (IV): [0.15 dl/g, with an estimated weight average molecular weight (Mw) range of approximately: 1600 to 2400 g/mol; 1.0 dl/g (Mw): 100,000 g/mol); and 1.8 dl/g (Mw): 80,000 to 100,000 g/mol] was employed for this study. The phase behavior of the polymer across different compositions of PLLA and solvent (CH2F2, CHF3, CO2, DME, F-22) in a wide range of temperatures from 333 to 425 K and high pressure 1.55 to 172 MPa was investigated. Miscibility of PLLA in DME and F-22 is predicted to be higher with increasing in concentration than the other cosolvents. Furthermore, in the case of the supercritical solvent CHF3 and DME the phase transition pressure curve of PLLA was observed to exhibit a lower critical solution temperature (LCST) type with a positive gradient with increasing temperature. However, lower phase transition pressure was noticed for lower molecular weight PLLA in supercritical solvent CHF3 and DME, i.e., of the order IV 0.15 dl/g

Objective This study aims to evaluate the MRI morphology of corpus callosum malformations and the associated anomalies frequently observed in a tertiary care center in northern India. Methods We conducted a retrospective cross-sectional study using MRI reports, images, and clinical records from January 2020 to July 2024. A total of 19 patients with corpus callosum agenesis or hypoplasia were identified, with 17 patients included after excluding those with incomplete records. We analyzed MRI findings for agenesis type (complete or partial), commissural abnormalities, midline anomalies, cortical abnormalities, and posterior fossa abnormalities. Statistical analysis was performed using chi-square tests to compare associations between complete and partial agenesis. Results Of the 17 patients, 52.9% had complete agenesis and 47.1% had partial agenesis. Complete agenesis was associated with higher rates of commissural involvement (44.4% vs. 12.5%), midline anomalies (22.2% vs. 0%), and Probst bundle formation (88.9% vs. 37.5%). Ventricular distortion was more common in complete agenesis (88.9% vs. 40%), and cortical malformations were also more prevalent (44.4% vs. 12.5%). Other anomalies included holoprosencephaly, Dandy-Walker malformation, and hypoxic-ischemic encephalopathy changes. Conclusion Complete agenesis of the corpus callosum is significantly associated with other commissural abnormalities, midline cysts, Probst bundle formation, ventricular distortions, and cortical malformations compared to partial agenesis. This study highlights the varied imaging presentations of corpus callosum malformations and their associated anomalies., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Saurya et al.)