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Hydrophobic non-ionic (type V) deep eutectic solvents (DESs) have recently emerged as a new class of sustainable materials that have shown unique properties in several applications. In this study, type V DESs thymol : camphor, menthol : thymol and eutectic mixtures (EMs) based on menthol : carboxylic acids with variable chain length, are experimentally investigated using xenon NMR spectroscopy, with the aim to clarify the peculiar nanostructure of these materials. The results, obtained from the analysis of the 129 Xe chemical shifts and of the longitudinal relaxation times, reveal a correlation between the deviation from ideality of the DESs and their structure free volume. Furthermore, the effect of varying the composition of DESs and EMs on the liquid structure is also studied.

Exosomes are promising therapeutics for tissue repair and regeneration to induce and guide appropriate immune responses in dystrophic pathologies. However, manipulating exosomes to control their biodistribution and targeting them in vivo to achieve adequate therapeutic benefits still poses a major challenge. Here we overcome this limitation by developing an externally controlled delivery system for primed annexin A1 myo-exosomes (Exo myo ). Effective nanocarriers are realized by immobilizing the Exo myo onto ferromagnetic nanotubes to achieve controlled delivery and localization of Exo myo to skeletal muscles by systemic injection using an external magnetic field. Quantitative muscle-level analyses revealed that macrophages dominate the uptake of Exo myo from these ferromagnetic nanotubes in vivo to synergistically promote beneficial muscle responses in a murine animal model of Duchenne muscular dystrophy. Our findings provide insights into the development of exosome-based therapies for muscle diseases and, in general, highlight the formulation of effective functional nanocarriers aimed at optimizing exosome biodistribution., (© 2024. The Author(s).)

Transparent nanocomposite films made of surface-modified titanium dioxide nanoparticles and thermoplastic polyurethane are prepared via film casting approach showing enhanced refractive indexes and mechanical properties. Two different sets of composites were prepared up to 37.5 wt % of inorganic nanoparticles with a diameter <15 nm, one set using particles capped only with oleic acid and a second one with a bimodal system layer made of oleic acid and mPEO-5000 as coating agents. All of the composites show significantly enhanced refractive index and mechanical properties than the neat polymeric matrix. The transparency of nanocomposite films shows the excellent dispersion of the inorganic nanoparticles in the polymeric matrix avoiding aggregation and precipitation phenomena. Our study provides a facile and feasible route to produce transparent nanocomposite films with tunable mechanical properties and high refractive indices for various applications., Competing Interests: The authors declare no competing financial interest., (© 2024 The Authors. Published by American Chemical Society.)