In the group of multiphase contactors and reactors, an important place belongs to reciprocat-ing plate columns (RPCs), which consist of a set of perforated plates fixed on a carrier (the so-called reciprocating or vibrating agitator) moving periodically up and down through a column. This construction maximizes the positive effects of mechanical agitation and minimizes or eliminates the adverse effects characteristic of column-type contactors and reactors. In RPCs, the highest dispersed-phase holdup is achieved at a lower dispersed-phase velocity due to the influence of mechanical agitation on the bubble or drop comminution. Therefore, this device can be the most acceptable contactor or reactor for performing complex actions in multiphase systems. The paper reviews the fundamental research and application of RPCs in Serbia in the last fifty years, from 1970 to 2020. Hydrodynamic and mass-transfer characteristics are analyzed, such as the pressure variation at the column bottom, power consumption, dispersed-phase holdup, axial dispersion, liquid mass transfer coefficient, specific interfacial area, and volumetric mass transfer coefficient. The use of RPCs as reactors in bioprocesses and biodiesel production processes is also discussed.