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Objectives: The relationship between task constraints and player behaviors is of interest to coaches tasked with designing practice to optimize learning. This study aims to compare the skill involvements and cooperative team behavior of teams of youth soccer players engaged in a goal exaggeration and/or a prescriptive coach instruction condition compared to a free-play control condition. Methods: Twenty male soccer players aged 12–15 participated in small-sided games under four conditions: free-play, goal exaggeration, prescriptive coach instruction, and combination over four weeks. Using video footage, teams’ collective skill involvements (shot, pass, dribble) and passing network characteristics (closeness, density, and betweenness) were measured for each game. Results: A Friedmans rank test identified that playing conditions resulted in significant differences in attempted dribbles (p < .001), goals scored (p < .001), network density (p = .001), closeness (p < .001) and betweenness (p = .002). Teams attempted to dribble the most in the free-play and goal-exaggeration conditions, and the most goals were scored in the goal-exaggeration and combination conditions. Additionally, teams exhibited more well-connected passing networks (i.e. higher density, higher closeness, and lower betweenness values) in the combination condition and higher network density in the explicit instruction condition. Conclusions: The results of this study indicate that coach instruction may be more associated with cooperative team behavior, whereas free-play or manipulating task constraints in the absence of instruction may be associated with players attempting more individual actions. [ABSTRACT FROM AUTHOR]

Lenalidomide and rituximab (R2) is an effective frontline treatment for patients with indolent B-cell non-Hodgkin lymphoma (iNHL). We investigated the safety and efficacy of addition of the proteasome inhibitor ixazomib to R2 for treatment of iNHL through a phase I/II clinical trial for high-risk patients. Twenty patients were enrolled, 18 were treated. The target dose of ixazomib 4 mg weekly was achieved during dose escalation. The most common treatment-related adverse events (AEs) were low grade gastrointestinal, rash, neuropathy, and myalgia/arthralgia. There were 33% grade 2 and 17% grade 3 infections. With median follow-up of 5.2 years, four patients discontinued treatment due to lymphoma progression. Best overall response rate (ORR) was 61.2% [55.6% CR, 5.6% PR): 22.2% had stable disease and 16.7% had disease progression. Kaplan-Meier estimates of progression free and overall survival (OS) were 73% and 87% at 36 months, respectively. R2 can safely be combined with ixazomib for treatment-naïve iNHL patients. [ABSTRACT FROM AUTHOR]

The negative impact of vacant and abandoned housing in city neighborhoods is extreme, affecting health and quality of life, promoting violence, and leading to further abandonment. One approach to addressing abandoned housing is to intervene with low-cost interventions that provide a visual sense of ownership. We tested whether a low-cost remediation of abandoned and vacant houses or a trash cleanup intervention would make a noticeable difference in the levels of nearby disrepair, disorder, and public safety. The abandoned housing remediation and trash cleanup interventions were a test of compliance with municipal ordinances. We used an experimental design to test the causal effects of the ordinances and because the scale of abandonment was too large to provide treatment to all abandoned houses in the city. We used systematic social observation methods to rate changes in disrepair, disorder, and litter at housing sites and on the city blocks they were located and police-reported data on gun violence and illegal substance use. Our experimental design allowed us to see whether observed disrepair, disorder, and public safety improved after working windows and doors were installed on abandoned houses compared with a trash cleanup around properties or a no-intervention control condition. Our results showed significant changes in observed disrepair, disorder, and gun violence and illustrate the benefits of experimental evaluations of place-based changes to the built environment. Improving compliance with ordinances to remediate abandoned housing can make a noticeable difference in disrepair in neighborhoods and contribute to improved public safety. We illustrate how planners can use field experiments in partnership with city agencies, nonprofit community groups, and local universities to discover novel approaches to advance place-based changes to the built environment that can help economically disadvantaged communities abate problems of physical disorder. [ABSTRACT FROM AUTHOR]

The article discusses a study comparing the knowledge of opioid overdose among college students and experienced opioid users. The study found that college students and opioid users had similar knowledge gaps regarding drug overdose and naloxone use. However, college students performed better in naloxone indication knowledge. The findings suggest that current overdose education programs may not need significant adaptation for college students. The study acknowledges limitations, such as the use of a local convenience sample and the lack of data on the students' drug use history. Further research is needed to replicate the findings and explore cultural adaptations. The given document is a list of references for a research study on opioid overdose education and naloxone utilization outcomes. The study compares the effects of brief versus extended opioid overdose education on individuals with opioid use disorder. Another reference examines the impact of brief overdose education on accurate recognition of opioid overdose among heroin users. A third reference explores the contexts and correlates of overdose experiences among US college students. These references provide valuable insights into the effectiveness of overdose education and its implications for different populations. [Extracted from the article]

Objectives : The relationship between task constraints and player behaviors is of interest to coaches tasked with designing practice to optimize learning. This study aims to compare the skill involvements and cooperative team behavior of teams of youth soccer players engaged in a goal exaggeration and/or a prescriptive coach instruction condition compared to a free-play control condition. Methods : Twenty male soccer players aged 12-15 participated in small-sided games under four conditions: free-play, goal exaggeration, prescriptive coach instruction, and combination over four weeks. Using video footage, teams' collective skill involvements (shot, pass, dribble) and passing network characteristics (closeness, density, and betweenness) were measured for each game. Results : A Friedmans rank test identified that playing conditions resulted in significant differences in attempted dribbles ( p  < .001), goals scored ( p  < .001), network density ( p  = .001), closeness ( p  < .001) and betweenness ( p  = .002). Teams attempted to dribble the most in the free-play and goal-exaggeration conditions, and the most goals were scored in the goal-exaggeration and combination conditions. Additionally, teams exhibited more well-connected passing networks (i.e. higher density, higher closeness, and lower betweenness values) in the combination condition and higher network density in the explicit instruction condition. Conclusions : The results of this study indicate that coach instruction may be more associated with cooperative team behavior, whereas free-play or manipulating task constraints in the absence of instruction may be associated with players attempting more individual actions.

Lenalidomide and rituximab (R 2 ) is an effective frontline treatment for patients with indolent B-cell non-Hodgkin lymphoma (iNHL). We investigated the safety and efficacy of addition of the proteasome inhibitor ixazomib to R 2 for treatment of iNHL through a phase I/II clinical trial for high-risk patients. Twenty patients were enrolled, 18 were treated. The target dose of ixazomib 4 mg weekly was achieved during dose escalation. The most common treatment-related adverse events (AEs) were low grade gastrointestinal, rash, neuropathy, and myalgia/arthralgia. There were 33% grade 2 and 17% grade 3 infections. With median follow-up of 5.2 years, four patients discontinued treatment due to lymphoma progression. Best overall response rate (ORR) was 61.2% [55.6% CR, 5.6% PR): 22.2% had stable disease and 16.7% had disease progression. Kaplan-Meier estimates of progression free and overall survival (OS) were 73% and 87% at 36 months, respectively. R 2 can safely be combined with ixazomib for treatment-naïve iNHL patients.

This study aimed to explore the perceptual-cognitive characteristics of coaches as they assessed team performance in youth soccer. The primary focus was to investigate the alignment between coaches' subjective analyses of team behaviour and objective analyses, while also examining the relationship between coaches' gaze behaviour and their levels of coaching experience, particularly considering the potential differences that may exist among coaches with varying levels of experience. Sixty-five male and female adults with various soccer coaching experience (experienced, novice, other team sport experience, and non-team sport experience) watched five 4-minute videos and assessed team behaviour. These subjective evaluations were compared to objective data obtained from video analysis and GPS, which included measures of completed skills, spatiotemporal characteristics, and passing networks. The participants' fixation duration and frequency were measured for each video clip, and the area around the ball specifically. The study found no significant differences between groups regarding the number of times participants' subjective analysis aligned with the objective data ( p  = 0.059, ɳ 2  = 0.07). However, coaches with soccer coaching experience demonstrated a higher fixation frequency and more revisits to the ball area when compared to participants without soccer experience ( p  = <.001, ɳ 2  = 0.09). The current study offers a unique approach to uncovering soccer coaching expertise by combining objective and subjective evaluations of team performance. In summary, the study reveals that coaching experience did not impact how often coaches subjective analyses matched objective data. However, soccer coaches had distinctive gaze behaviour patterns where they revisited the area around the ball more often.