17 results on '"Sorteberg A"'
Search Results
2. Prompt closure versus gradual weaning of external ventricular drain for hydrocephalus following aneurysmal subarachnoid haemorrhage: a statistical analysis plan for the DRAIN randomised clinical trial
- Author
-
Tenna Capion, Alexander Lilja-Cyron, Marianne Juhler, Kirsten Møller, Angelika Sorteberg, Pål André Rønning, Frantz Rom Poulsen, Joakim Wismann, Anders Emil Schack, Celina Ravlo, Jørgen Isaksen, Jane Lindschou, Christian Gluud, Tiit Mathiesen, and Markus Harboe Olsen
- Subjects
Aneurysm ,Aneurysmal subarachnoid haemorrhage ,Hydrocephalus ,External ventricular drain ,Weaning ,Randomised clinical trial ,Medicine (General) ,R5-920 - Abstract
Abstract Background Insertion of an external ventricular drain (EVD) is a first-line treatment of acute hydrocephalus caused by aneurysmal subarachnoid haemorrhage (aSAH). Once the patient is clinically stable, the EVD is either removed or replaced by a permanent internal shunt. The optimal strategy for cessation of the EVD is unknown. Prompt closure carries a risk of acute hydrocephalus or redundant shunt implantations, whereas gradual weaning may increase the risk of EVD-related infections. Methods DRAIN (Danish RAndomised Trial of External Ventricular Drainage Cessation IN Aneurysmal Subarachnoid Haemorrhage) is an international multicentre randomised clinical trial comparing prompt closure versus gradual weaning of the EVD after aSAH. The primary outcome is a composite of VP-shunt implantation, all-cause mortality, or EVD-related infection. Secondary outcomes are serious adverse events excluding mortality and health-related quality of life (EQ-5D-5L). Exploratory outcomes are modified Rankin Scale, Fatigue Severity Scale, Glasgow Outcome Scale Extended, and length of stay in the neurointensive care unit and hospital. Outcome assessment will be performed 6 months after ictus. Based on the sample size calculation (event proportion 80% in the gradual weaning group, relative risk reduction 20%, alpha 5%, power 80%), 122 participants are required in each intervention group. Outcome assessment for the primary outcome, statistical analyses, and conclusion drawing will be blinded. Two independent statistical analyses and reports will be tracked using a version control system, and both will be published. Based on the final statistical report, the blinded steering group will formulate two abstracts. Conclusion We present a pre-defined statistical analysis plan for the randomised DRAIN trial, which limits bias, p-hacking, and data-driven interpretations. This statistical analysis plan is accompanied by tables with simulated data, which increases transparency and reproducibility. Trial registration ClinicalTrials.gov identifier: NCT03948256. Registered on May 13, 2019.
- Published
- 2024
- Full Text
- View/download PDF
3. Genome Editing of a Macroalgae with Possible Global Impacts
- Author
-
Opsahl-Sorteberg, Hilde-Gunn, Evju, Espen, Ricroch, Agnès, editor, Eriksson, Dennis, editor, Miladinović, Dragana, editor, Sweet, Jeremy, editor, Van Laere, Katrijn, editor, and Woźniak-Gientka, Ewa, editor
- Published
- 2024
- Full Text
- View/download PDF
4. A Short Review of Advances in Plant-Based Antigen Production Strategies and the Production of Viral Vaccine Antigens Derived from CRISPR/Cas9 Genome Edited N. benthamiana Plants for Enhanced Vaccine Efficacy
- Author
-
Evju, Espen, Opsahl-Sorteberg, Hilde-Gunn, Ricroch, Agnès, editor, Eriksson, Dennis, editor, Miladinović, Dragana, editor, Sweet, Jeremy, editor, Van Laere, Katrijn, editor, and Woźniak-Gientka, Ewa, editor
- Published
- 2024
- Full Text
- View/download PDF
5. Assessment of wind–damage relations for Norway using 36 years of daily insurance data
- Author
-
A. Jaison, A. Sorteberg, C. Michel, and Ø. Breivik
- Subjects
Environmental technology. Sanitary engineering ,TD1-1066 ,Geography. Anthropology. Recreation ,Environmental sciences ,GE1-350 ,Geology ,QE1-996.5 - Abstract
Extreme winds are by far the largest contributor to Norway’s insurance claims related to natural hazards. The predictive skills of four different damage functions are assessed for Norway at the municipality and national levels on daily and annual temporal scales using municipality-level insurance data and the high-resolution Norwegian hindcast (NORA3) wind speed data for the period 1985–2020. Special attention is given to extreme damaging events and occurrence probabilities of wind-speed-induced damage. Because of the complex topography of Norway and the resulting high heterogeneity of the population density, the wind speed is weighted with the population. The largest per capita losses and severe damage occur most frequently in the western municipalities of Norway, which are more exposed to incoming storms from the North Atlantic, whilst there are seldom any large losses further inland. There is no single damage function that outperforms others. However, a good agreement between the observed and estimated losses at municipality and national levels for a combination of damage functions suggests their usability in estimating severe damage associated with windstorms. Furthermore, the damage functions are able to successfully reconstruct the geographical pattern of losses caused by extreme windstorms with a high degree of correlation. From event occurrence probabilities, the present study devises a damage classifier that exhibits some skill at distinguishing between daily damaging and non-damaging events at the municipality level. While large-loss events are well captured, the skewness and zero inflation of the loss data greatly reduce the quality of both the damage functions and the classifier for moderate- and weak-loss events.
- Published
- 2024
- Full Text
- View/download PDF
6. Norwegian offshore wind power—Spatial planning using multi‐criteria decision analysis
- Author
-
Ida Marie Solbrekke and Asgeir Sorteberg
- Subjects
analytical hierarchy process ,multi‐criteria decision analysis ,optimal offshore wind farm siting ,wind farm spatial planning ,Renewable energy sources ,TJ807-830 - Abstract
Abstract The Norwegian government recently agreed on the goal 30by40, which involves opening Norwegian offshore areas to host 30 GW of installed wind power by 2040. We address this goal by presenting a first mapping of wind power suitability scores (WPSS) for the entire Norwegian economic zone (NEZ) using a multi‐criteria decision analysis framework (MCDA), namely, the analytical hierarchical process (AHP) approach. We obtain WPSS considering relevant criteria like wind resources, techno‐economic aspects, social acceptance, environmental considerations, and met‐ocean constraints such as wind and wave conditions. The results starts with a baseline scenario, where the criterion importance is pairwise compared in the context of balancing economic incentives and conflicting interests. Additionally, to reveal regions that are robust to changes in criterion importance, we carry out a sensitivity analysis by introducing three additional scenarios. These scenarios represent stereotypical actors with distinct preferences for siting of wind farms: the investor, the environmentalist, and the fisherman. The results show that the southern part of the NEZ is the most suitable and robust region for offshore wind power deployment. This region receives the highest suitability category (“very high” suitability for wind power application) throughout all the scenarios. Areas in the Norwegian part of the Barents Sea and the near‐coastal areas outside mid‐Norway are also well suited regions, but these are more sensitive to the choice of criterion importance. The use of AHP within the framework of MCDA is shown to be a promising tool for pinpointing the best Norwegian offshore areas for wind power application.
- Published
- 2024
- Full Text
- View/download PDF
7. Dynamic cerebral autoregulation is preserved during orthostasis and intrathoracic pressure regulation in healthy subjects: A pilot study
- Author
-
M. Skytioti, M. Wiedmann, A. Sorteberg, L. Romundstad, Y. Hassan Ali, A. Mohammad Ayoubi, I. Zilakos, and M. Elstad
- Subjects
cerebral autoregulation ,hemodynamics ,impedance threshold device ,passive tilting ,resistance breathing ,synchronization index ,Physiology ,QP1-981 - Abstract
Abstract Resistance breathing may restore cardiac output (CO) and cerebral blood flow (CBF) during hypovolemia. We assessed CBF and cerebral autoregulation (CA) during tilt, resistance breathing, and paced breathing in 10 healthy subjects. Blood velocities in the internal carotid artery (ICA), middle cerebral arteries (MCA, four subjects), and aorta were measured by Doppler ultrasound in 30° and 60° semi‐recumbent positions. ICA blood flow and CO were calculated. Arterial blood pressure (ABP, Finometer), and end‐tidal CO2 (ETCO2) were recorded. ICA blood flow response was assessed by mixed‐models regression analysis. The synchronization index (SI) for the variable pairs ABP–ICA blood velocity, ABP–MCA velocities in 0.005–0.08 Hz frequency interval was calculated as a measure of CA. Passive tilting from 30° to 60° resulted in 12% decrease in CO (p = 0.001); ICA blood flow tended to fall (p = 0.04); Resistance breathing restored CO and ICA blood flow despite a 10% ETCO2 drop. ETCO2 and CO contributed to ICA blood flow variance (adjusted R2: 0.9, p
- Published
- 2024
- Full Text
- View/download PDF
8. Return to work after aneurysmal subarachnoid hemorrhage
- Author
-
Angelika Sorteberg, Aslan Lashkarivand, and Elin Western
- Subjects
return to work ,aneurysmal subarachnoid hemorrhage ,fatigue ,outcome ,poor grade aneurysmal SAH ,aneurysm repair ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
IntroductionSurvivors of aneurysmal subarachnoid hemorrhage (aSAH) often recover without severe physical or cognitive deficits. However, strikingly low levels of engagement in productive employment have also been reported in aSAH patients with good or excellent outcomes. Knowledge about return to work (RTW) after aSAH and predictors of no RTW remain limited and controversial. The study aimed to delineate the return to maximum work capacity up to 5 years after the ictus in a larger number of consecutive aSAH patients from the entire aSAH severity spectrum and to identify demographic and medical predictors of no RTW.MethodsData were acquired from a prospective institutional database. We included all 500 aSAH survivors aged > 18 years who were treated between January 2012 and March 2018. In addition to gathering data on work status and the type of work at ictus, we retrieved demographical data and assessed aSAH severity based on the quantification of subarachnoid, intraventricular, and intraparenchymal blood (ICH), as well as the World Federation of Neurological Societies (WFNS) grade. We registered the mode of aneurysm repair (endovascular or surgical) and recorded complications such as vasospasm, newly acquired cerebral infarctions, and chronic hydrocephalus.ResultsFurthermore, work status and the grade of fatigue at follow-up were registered. RTW was assessed among 299 patients who were employed at ictus. Among them, 63.2% were women, and their age was 51.3 ± 9.4 (20–71) years. Return to gainful employment was 51.2%, with complete RTW accounting for 32.4%. The independent predictors of no RTW at ictus were age, the WFNS grade 3, and active smoking. The strongest independent predictor was the presence of clinically significant fatigue, which increased the risk of not returning to work by 5-fold. The chance to return to gainful employment significantly increased with the individual's years of education prior to their hemorrhage. The mode of aneurysm repair was not relevant with regard to RTW. Patients in the WFNS grades 1–2 more often returned to work than those in the WFNS grades 3–5, but our results indicate that neurological motor deficits are linked closer to no RTW than aSAH severity per se.ConclusionFatigue needs to be addressed as an important element on the path to return to work integration.
- Published
- 2024
- Full Text
- View/download PDF
9. SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma
- Author
-
Abdelrazak Morsy, Mohammad Hamdy, Lilienthal, Ingrid, Lord, Martin, Merrien, Magali, Wasik, Agata Magdalena, Sureda-Gómez, Marta, Amador, Virginia, Johansson, Henrik J., Lehtiö, Janne, Garcia-Torre, Beatriz, Martin-Subero, Jose Ignacio, Tsesmetzis, Nikolaos, Tao, Sijia, Schinazi, Raymond F., Kim, Baek, Sorteberg, Agnes L., Wickström, Malin, Sheppard, Devon, Rassidakis, Georgios Z., Taylor, Ian A., Christensson, Birger, Campo, Elias, Herold, Nikolas, and Sander, Birgitta
- Published
- 2024
- Full Text
- View/download PDF
10. Projections of windstorms damages under changing climate and demography for Norway
- Author
-
Ashbin Jaison, Clio Michel, Asgeir Sorteberg, and Øyvind Breivik
- Subjects
extreme wind ,damage ,climate change ,exposure ,Meteorology. Climatology ,QC851-999 ,Environmental sciences ,GE1-350 - Abstract
Windstorms cause severe damages and are the dominant natural hazard responsible for insurance payouts in Norway. Using future wind speeds from twenty bias corrected regional climate model simulations from EURO-CORDEX and four damage functions, fitted on municipality level to observed insurance losses, we estimate storm related losses to increase in all Norwegian counties due to climate change. At national level, there is an increase in storm losses in the far future, but some counties and municipalities can still exhibit a decrease in losses. Under a changing climate, despite a decrease in the 98th percentile of the wind speed, the most extreme winds increase, and this drives an increase in the windstorm damages. We also show that the wind load design values may need to be re-evaluated to take into account the changing wind speeds. In addition to climate change, the impact of future exposure changes in the form of population changes using municipality-level population projections is shown to be important for determining the level of future windstorm damage risk. Overall, the loss projections show a large spread, highlighting their sensitivity to the choice of the storm-damage function and to the choice of the simulation.
- Published
- 2024
- Full Text
- View/download PDF
11. Dynamic cerebral autoregulation is preserved during orthostasis and intrathoracic pressure regulation in healthy subjects: A pilot study
- Author
-
Skytioti, M., primary, Wiedmann, M., additional, Sorteberg, A., additional, Romundstad, L., additional, Hassan Ali, Y., additional, Mohammad Ayoubi, A., additional, Zilakos, I., additional, and Elstad, M., additional
- Published
- 2024
- Full Text
- View/download PDF
12. Linking Future Precipitation Changes to Weather Features in CESM2‐LE.
- Author
-
Konstali, Kjersti, Spengler, Thomas, Spensberger, Clemens, and Sorteberg, Asgeir
- Subjects
ATMOSPHERIC models ,ATMOSPHERIC rivers ,STORMS ,WEATHER ,CLIMATE change ,CYCLONES - Abstract
Weather features, such as extratropical cyclones, atmospheric rivers (ARs), and fronts, contribute to substantial amounts of precipitation globally and are associated with different precipitation characteristics. However, future changes in these characteristics, as well as their representation in climate models, remain uncertain. We attribute 6‐hourly accumulated precipitation to cyclones, moisture transport axes (AR‐like features), fronts, and cold air outbreaks, and the combinations thereof in 10 ensemble members of the CESM2‐LE between 1960 and 2100 under the SSP3‐7.0 scenario. We find that, despite some biases in both precipitation and weather features, CESM2‐LE adeptly represents the precipitation characteristics associated with the different combinations of weather features. The combinations of weather features that contribute most to precipitation in the present climate also contribute the most to future changes, both due to changes in intensity as well as frequency. While the increase in precipitation intensity dominates the overall response for total precipitation in the storm track regions, the precipitation intensity for the individual weather features does not necessarily change significantly. Instead, approximately half of the increase in precipitation intensity in the storm track regions can be attributed to a higher occurrence of the more intensely precipitating combinations of weather features, such as the co‐occurrence of extratropical cyclones, fronts, and moisture transport axes. Plain Language Summary: Most precipitation is associated with weather features such as storms, atmospheric rivers, and fronts. Different combinations of these weather features are associated with different precipitation characteristics, but how these characteristics are represented in climate models as well as their possible future changes is not known. We attribute 6‐hourly accumulated precipitation to weather features, such as storms, fronts, and atmospheric rivers, from 1960 to 2100 under a high greenhouse emission scenario in a climate model. Despite some biases, the climate model represents the precipitation characteristics associated with these weather features well. We find that the weather features with the largest contribution to precipitation in the current climate also contribute the most to future changes in precipitation. The changes are caused by changes in both frequency of occurrence and precipitation intensity. Key Points: We attribute precipitation to cyclones, fronts, moisture transport axes, and cold air outbreaks in 10 ensemble members CESM2‐LE in 1960–2100CESM2‐LE adeptly represents the precipitation characteristics associated with the different weather features and their combinationsCo‐occurring weather features, associated with intense precipitation, contribute to a larger fraction of the precipitation in the future [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
13. SOX11 is a novel binding partner and endogenous inhibitor of SAMHD1 ara-CTPase activity in mantle cell lymphoma.
- Author
-
Morsy, Mohammad Hamdy Abdelrazak, primary, Lilienthal, Ingrid, additional, Lord, Martin, additional, Merrien, Magali, additional, Wasik, Agata Magdalena, additional, Amador, Virginia, additional, Sureda-Gómez, Marta, additional, Johansson, Henrik J, additional, Lehtiö, Janne, additional, García-Torre, Beatriz, additional, Martin-Subero, Jose Ignacio, additional, Tsesmetzis, Nikolaos, additional, Tao, Sijia, additional, Schinazi, Raymond F, additional, Kim, Baek, additional, Sorteberg, Agnes L, additional, Wickström, Malin, additional, Sheppard, Devon, additional, Rassidakis, Georgios Z, additional, Taylor, Ian A, additional, Christensson, Birger, additional, Campo, Elías, additional, Herold, Nikolas, additional, and Sander, Birgitta, additional
- Published
- 2024
- Full Text
- View/download PDF
14. Return to work after aneurysmal subarachnoid hemorrhage.
- Author
-
Sorteberg, Angelika, Lashkarivand, Aslan, and Western, Elin
- Subjects
SUBARACHNOID hemorrhage ,CEREBRAL infarction ,INTERNATIONAL organization ,DATABASES ,HYDROCEPHALUS - Abstract
Introduction: Survivors of aneurysmal subarachnoid hemorrhage (aSAH) often recover without severe physical or cognitive deficits. However, strikingly low levels of engagement in productive employment have also been reported in aSAH patients with good or excellent outcomes. Knowledge about return to work (RTW) after aSAH and predictors of no RTW remain limited and controversial. The study aimed to delineate the return to maximum work capacity up to 5 years after the ictus in a larger number of consecutive aSAH patients from the entire aSAH severity spectrum and to identify demographic and medical predictors of no RTW. Methods: Data were acquired from a prospective institutional database. We included all 500 aSAH survivors aged > 18 years who were treated between January 2012 and March 2018. In addition to gathering data on work status and the type of work at ictus, we retrieved demographical data and assessed aSAH severity based on the quantification of subarachnoid, intraventricular, and intraparenchymal blood (ICH), as well as the World Federation of Neurological Societies (WFNS) grade. We registered the mode of aneurysm repair (endovascular or surgical) and recorded complications such as vasospasm, newly acquired cerebral infarctions, and chronic hydrocephalus. Results: Furthermore, work status and the grade of fatigue at follow-up were registered. RTW was assessed among 299 patients who were employed at ictus. Among them, 63.2% were women, and their age was 51.3 ± 9.4 (20-71) years. Return to gainful employment was 51.2%, with complete RTW accounting for 32.4%. The independent predictors of no RTW at ictus were age, the WFNS grade 3, and active smoking. The strongest independent predictor was the presence of clinically significant fatigue, which increased the risk of not returning to work by 5-fold. The chance to return to gainful employment significantly increased with the individual's years of education prior to their hemorrhage. The mode of aneurysm repair was not relevant with regard to RTW. Patients in the WFNS grades 1-2 more often returned to work than those in the WFNS grades 3-5, but our results indicate that neurological motor deficits are linked closer to no RTW than aSAH severity perse. Conclusion: Fatigue needs to be addressed as an important element on the path to return to work integration. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
15. Assessment of wind–damage relations for Norway using 36 years of daily insurance data.
- Author
-
Jaison, Ashbin, Sorteberg, Asgeir, Michel, Clio, and Breivik, Øyvind
- Subjects
WINDSTORMS ,WIND speed ,INSURANCE claims ,INSURANCE ,POPULATION density - Abstract
Extreme winds are by far the largest contributor to Norway's insurance claims related to natural hazards. The predictive skills of four different damage functions are assessed for Norway at the municipality and national levels on daily and annual temporal scales using municipality-level insurance data and the high-resolution Norwegian hindcast (NORA3) wind speed data for the period 1985–2020. Special attention is given to extreme damaging events and occurrence probabilities of wind-speed-induced damage. Because of the complex topography of Norway and the resulting high heterogeneity of the population density, the wind speed is weighted with the population. The largest per capita losses and severe damage occur most frequently in the western municipalities of Norway, which are more exposed to incoming storms from the North Atlantic, whilst there are seldom any large losses further inland. There is no single damage function that outperforms others. However, a good agreement between the observed and estimated losses at municipality and national levels for a combination of damage functions suggests their usability in estimating severe damage associated with windstorms. Furthermore, the damage functions are able to successfully reconstruct the geographical pattern of losses caused by extreme windstorms with a high degree of correlation. From event occurrence probabilities, the present study devises a damage classifier that exhibits some skill at distinguishing between daily damaging and non-damaging events at the municipality level. While large-loss events are well captured, the skewness and zero inflation of the loss data greatly reduce the quality of both the damage functions and the classifier for moderate- and weak-loss events. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
16. Global Attribution of Precipitation to Weather Features.
- Author
-
Konstali, Kjersti, Spensberger, Clemens, Spengler, Thomas, and Sorteberg, Asgeir
- Subjects
ATMOSPHERIC rivers ,CYCLONES ,WEATHER ,CLIMATOLOGY ,FRONTS (Meteorology) ,LATITUDE - Abstract
Weather features, such as extratropical cyclones (ETCs), atmospheric rivers (ARs), and fronts, contribute to substantial amounts of precipitation globally. However, previous estimates of how much these individual features contribute to precipitation are very sensitive to subjectively chosen metrics. Furthermore, there is no information on how these weather features contribute to precipitation poleward of 60° latitude. To alleviate these shortcomings, we introduce a more robust attribution method applicable at all latitudes. Based on ERA5, we present the first global climatology of the contributions from cyclones, fronts, moisture transport axes (MTAs; AR-like features), and cold air outbreaks, as well as their combinations, to summer and winter precipitation as well as extreme precipitation. Most of the precipitation in the midlatitudes relates to the combination of ETC, fronts, and MTAs (28%), while in polar regions most precipitation occurs within the ETC-only category (27%). Extreme precipitation events in all extratropical regions are predominantly associated with the combination of ETCs, fronts, and MTAs (46%). In the midlatitudes, the combination of ETCs, fronts, and MTAs occurs almost 4 times as often during extreme events compared to regular events. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
17. Norwegian offshore wind power—Spatial planning using multi‐criteria decision analysis.
- Author
-
Solbrekke, Ida Marie and Sorteberg, Asgeir
- Subjects
WIND power ,MULTIPLE criteria decision making ,DECISION making ,WIND power plants ,ANALYTIC hierarchy process ,MONETARY incentives - Abstract
The Norwegian government recently agreed on the goal 30by40, which involves opening Norwegian offshore areas to host 30 GW of installed wind power by 2040. We address this goal by presenting a first mapping of wind power suitability scores (WPSS) for the entire Norwegian economic zone (NEZ) using a multi‐criteria decision analysis framework (MCDA), namely, the analytical hierarchical process (AHP) approach. We obtain WPSS considering relevant criteria like wind resources, techno‐economic aspects, social acceptance, environmental considerations, and met‐ocean constraints such as wind and wave conditions. The results starts with a baseline scenario, where the criterion importance is pairwise compared in the context of balancing economic incentives and conflicting interests. Additionally, to reveal regions that are robust to changes in criterion importance, we carry out a sensitivity analysis by introducing three additional scenarios. These scenarios represent stereotypical actors with distinct preferences for siting of wind farms: the investor, the environmentalist, and the fisherman. The results show that the southern part of the NEZ is the most suitable and robust region for offshore wind power deployment. This region receives the highest suitability category ("very high" suitability for wind power application) throughout all the scenarios. Areas in the Norwegian part of the Barents Sea and the near‐coastal areas outside mid‐Norway are also well suited regions, but these are more sensitive to the choice of criterion importance. The use of AHP within the framework of MCDA is shown to be a promising tool for pinpointing the best Norwegian offshore areas for wind power application. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.