A recent study conducted in Chandigarh, India, explored the genetic factors contributing to iron-refractory iron deficiency anemia (IRIDA) in pregnant women. The researchers screened 500 pregnant women with iron deficiency anemia and identified a cohort of 10 individuals with IRIDA. They found significant differences in hematological and biochemical markers between iron responders and non-responders, with non-responders showing lower levels of hemoglobin, red blood cells, serum iron, and serum ferritin. Genetic sequencing revealed 10 novel variants in the TMPRSS6 gene, with four missense variants having a high functional impact. The study provides valuable insights into the prevalence, genetic mechanisms, and underlying causes of IRIDA in pregnant women in the Indian subcontinent. Further research collaboration is needed to validate these findings and develop effective treatments. [Extracted from the article]