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In this present investigation, we have successfully synthesized Co 2 + doped CeO 2 nanoparticles (NPs) within the dopant range of 1–11 mol% using a versatile solution combustion synthesis method, employing Aloe vera extract as a potent reducing agent. To substantiate the efficacy of our synthesis process, we employed a diverse array of characterization techniques. The PXRD analysis unequivocally confirmed the formation of a cubic fluorite structure characterized by the Fm-3m space group. The average crystallite size computed from both the Scherrer equation and W–H plot is found to be in the range of 14.98–19.52 nm. Notably, our investigation revealed a consistent decrease in the average crystallite size from 19.52 to 16.68 nm and an increase in the direct energy band gap from 3.069 to 3.078 eV as the Co dopant concentration increased from 1–11 mol%. Surface morphology analysis confirmed the formation of NPs with a high degree of agglomeration with irregularly shaped NPs arranged one over the other. The photoluminescence emission spectra were recorded at an excitation wavelength of 390 nm showing a strong emission peak at 697 nm. At 7 mol% doping concentration quenching is noticed. CIE coordinates confirmed the Co 2 + doped CeO 2 NPs fall under red color with CCT values from 1713 to 1796 K i.e. warm light. Electrochemical analysis reveals the specific capacitance range of NPs is from 26 to 52.5 F/g. The energy density is found to be highest i.e. 1419 Wh/g for 7 mol% Co doped CeO 2 NPs. Collectively, our research suggests a promising avenue for the practical application of these NPs in advanced energy storage devices. [ABSTRACT FROM AUTHOR]

Plant protein-based edible film and coatings have emerged as eco-friendly alternatives to synthetic packaging, offering biodegradable, non-toxic solutions. Their biocompatibility and film-forming properties make them suitable for direct application on food products, reducing reliance on non-degradable plastics and lowering environmental pollution. Despite their promising advantages, challenges remain in optimizing mechanical properties, production scalability, and consumer acceptance. This review explores various plant protein sources, latest developments in film-forming techniques, and approaches to address current challenges in developing protein-based film and coatings, highlighting their potential applications in food-pharma industries. Plant-based protein films and coatings have good gas barriers and mechanical qualities. Using plasticizers and post treatments improved physical and mechanical properties of protein-based film and coatings. Moreover, plant protein-based films (PBFs) with active components can slow microbial growth and lipid oxidation. Overall, plant protein-based edible films and coatings hold promise for improving food quality and safety by incorporating bioactive compounds and enhancing barrier properties. However, gaps remain in optimizing their physio-mechanical characteristics, scaling up production, and exploring novel protein sources for diverse applications in food and pharmaceuticals., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025 Elsevier B.V. All rights reserved.)

Garcinia lanceifolia Roxb. ( Rupohi thekera ), an underutilized minor fruit from Assam, holds significant potential as it exhibits substantial traditional medicinal properties. However, its preservation and utilization remain limited, necessitating effective processing techniques. This study aimed to compare the impact of tray drying and freeze drying on the physico-chemical, antioxidant, and functional properties of G. lanceifolia . Fresh fruits were processed using both methods, followed by detailed analyses of nutritional composition, phytochemical content, antioxidant activity, and functional properties. Freeze drying resulted in greater retention of moisture (12.42 ± 0.81%), protein (4.44 ± 0.19%), carbohydrate content (8.29 ± 0.31 g/100 g), and reducing sugar (1.95 ± 0.12%), along with prominent color quality, while no significant difference in ash content was found for either drying method employed. Phytochemical extraction using different solvents (water, n-hexane, 80% methanol, 80% ethanol, and 80% acetone) revealed that freeze-dried samples extracted with acetone had the highest total phenolic content (634.00 ± 1.73 mg GAE/100 g), while methanol extraction yielded the highest total flavonoid content (382.33 ± 1.52 mg QE/100 g). Tray drying, on the other hand, exhibited superior DPPH and FRAP when subjected to ethanol extract (80.24 ± 0.42% and 83.83 ± 0.46 mg/100 g, respectively) and metal chelation capacity (23.69 ± 2.09%). Additionally, functional properties, such as glucose adsorption capacity and α-amylase inhibition, were found to vary between drying techniques, with freeze-dried samples showing better glucose adsorption and tray-dried samples demonstrating greater α-amylase inhibition. FTIR analysis highlighted distinct structural attributes of bioactive compounds retained through both methods. The findings underscore the potential of freeze drying for nutrient preservation and tray drying for cost-effective applications, paving the way for the industrial valorization of G. lanceifolia as a functional food ingredient.

Background: Newer generation platelet concentrates, such as advanced platelet-rich fibrin plus (A-PRF+) obtained following low-speed centrifugation concept and horizontal platelet-rich fibrin (H-PRF) obtained from swing out and bucket system, showed increased platelet entrapment and growth factor release in the in-vitro studies. This prospective study aimed to evaluate and compare the clinical outcomes of A-PRF+ and H-PRF membranes in the treatment of gingival recession defects. The objectives of this study were to compare the changes in the recession height (RH) and the mean root coverage percentage (MRC%) between and within the research groups., Methods: Forty-four systemically healthy patients diagnosed with 84 Cairo's RT 1 and RT 2 gingival recession defects in the maxillary anterior and premolars were randomly treated with a combination of the coronally advanced flap (CAF) and A-PRF+ membrane (n = 22 subjects) or H-PRF membrane (n = 22 subjects). Patients were reviewed at 3 and 6 months postoperatively. Parameters including RH, MRC%, complete root coverage (CRC), gingival thickness, keratinized tissue height, and root coverage esthetic scores were documented., Results: Both treatments resulted in a significant reduction in RH (p < 0.001). The CAF + A-PRF+ group demonstrated a reduction in RH from 2.47 ± 1.00 mm to 0.59 ± 0.52 mm and the MRC% was 76.33 ± 22.54%, at 6 months. In the CAF+H-PRF group, the mean RH decreased from 2.43 ± 1.01 mm to 0.38 ± 0.59 mm and the MRC% was 85.51 ± 19.87%. Three- and six-month intergroup analysis revealed statistically insignificant differences in the observed clinical parameters between the groups (p > 0.05)., Conclusions: The study found that both CAF + H-PRF and CAF + A-PRF+ protocols resulted in similar clinical outcomes while treating maxillary gingival recession defects., Plain Language Summary: Numerous modifications have been proposed to improve the growth factor content in the platelet concentrates and thereby therapeutic potential. This study compared platelet-derived membranes obtained by two different spin protocols in the treatment of gum recession. Forty-four patients were treated with either platelet-derived membrane obtained by horizontal spin protocol (test group) or low-speed spin concept (control group). Both treatment methods resulted in satisfactory healing. At the end of 6 months, no differences were noted with regard to the changes in clinical measurements and root coverage percentage indicating similar clinical efficacy of both preparatory techniques., (© 2025 American Academy of Periodontology.)

Antioxidants are crucial in reducing oxidative stress and enhancing health, necessitating precise quantification in food matrices. Advanced techniques such as biosensors and nanosensors offer high sensitivity and specificity, enabling real-time monitoring and accurate antioxidant quantification in complex food systems. These technologies herald a new era in food analysis, improving food quality and safety through sophisticated detection methods. Their application facilitates comprehensive antioxidant profiling, driving innovation in food technology to meet the rising demand for nutritional optimization and food integrity. These are complemented by electrochemical techniques, spectroscopy, and chromatography. Electrochemical methods provide rapid response times, spectroscopy offers versatile chemical composition analysis, and chromatography excels in precise separation and quantification. Collectively, these methodologies establish a comprehensive framework for food analysis, essential for improving food quality, safety, and nutritional value. Future research should aim to refine these analytical methods, promising significant advancements in food and nutritional science., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

In recent years, there has been a notable surge in the development and adoption of edible algae protein-based sustainable food packaging, which presents a promising alternative to traditional materials due to its biodegradability, renewability, and minimal environmental impact. Hence, this review aims to emphasize the sources, cultivation, and downstream potential of algal protein and protein complexes. Moreover, it comprehensively examines the advancements in utilizing protein complexes for smart and active packaging applications, while also addressing the challenges that must be overcome for the widespread commercial adoption of algal proteins to meet industry 4.0. The review revealed that the diversity of algae species and their sustainable cultivation methods offers a promising alternative to traditional protein sources. Being vegan source with higher photosynthetic conversion efficiency and reduced growth cycle has permitted the proposition of algae as proteins of the future. The unique combination of techno-functional combined with bio-functional properties such as antioxidant, anti-inflammatory and antimicrobial response have captured the sustainable groups to invest considerable research and promote the innovations in algal proteins. Food packaging research has increasingly benefited by the excellent gas barrier property and superior mechanical strength of algal proteins either stand alone or in synergy with other biodegradable polymers. Advanced packaging functionality such as freshness monitoring and active preservation techniques has been explored and needs considerable characterization for commercial advancement. Overall, while algal proteins show promising downstream potential in various industries aligned with Industry 4.0 principles, their broader adoption hinges on overcoming these barriers through continued innovation and strategic development., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

The causative agent of Lyme disease, Borrelia burgdorferi , is endemic to Canada, the northeastern United States, northern California, and temperate European regions. It is rarely associated with a travel-related exposure. In this report, we describe a resident of southern Ontario, Canada who developed rash, fever, and cranial nerve VII and XII palsies following a 12 day trip to Ecuador and the Galapagos islands approximately four weeks prior to referral to our center. Comprehensive microbiological work-up was notable for reactive Borrelia burgdorferi serology by modified two-tier testing (MTTT), confirming a diagnosis of Lyme disease. This case highlights important teaching points, including the classic clinical presentation of acute Lyme disease with compatible exposure pre-travel in a Lyme-endemic region of Ontario, initial manifestations during travel following acquisition of arthropod bites in Ecuador, and more severe manifestations post-travel. Given the travel history to a South American country in which Lyme disease is exceedingly uncommon, consideration of infections acquired in Ecuador necessitated a broad differential diagnosis and more comprehensive microbiological testing than would have been required in the absence of tropical travel. Additionally, cranial nerve XII involvement is an uncommon feature of Lyme neuroborreliosis, and therefore warranted consideration of an alternative, non-infectious etiology such as stroke or a mass lesion, both of which were excluded in this patient through neuroimaging.

Malignant growth is expected to surpass other significant causes of death as one of the top reasons for dismalness and mortality worldwide. According to a World Health Organization (WHO) study, this illness causes approximately between 9 and 10 million instances of deaths annually. Chemotherapy, radiation, and surgery are the three main methods of treating cancer. These methods seek to completely eradicate all cancer cells while having the fewest possible unintended impacts on healthy cell types. Owing to the lack of target selectivity, the majority of medications have substantial side effects. On the other hand, nanomaterials have transformed the identification, diagnosis, and management of cancer. Nanostructures with biomimetic properties have been grown as of late, fully intent on observing and treating the sickness. These nanostructures are expected to be consumed by growth in areas with profound disease. Furthermore, because of their extraordinary physicochemical properties, which incorporate nanoscale aspects, a more prominent surface region, explicit geometrical features, and the ability to embody different substances within or on their outside surfaces, nanostructures are remarkable nano-vehicles for conveying restorative specialists to their designated regions. This review discusses recent developments in nanostructured materials such as graphene, dendrimers, cell-penetrating peptide nanoparticles, nanoliposomes, lipid nanoparticles, magnetic nanoparticles, and nano-omics in the diagnosis and management of cancer.

Food waste, accounting for about one-third of the total global food resources wasted each year, is a substantial challenge to global sustainability, contributing to adverse environmental impacts. The utilization of food waste as a valuable source for bioactive extraction can be facilitated through the application of DES (Deep Eutectic Solvents). Acknowledging the significant need to tackle this issue, the United Nations integrated food waste management into its Sustainable Development Goals, hence, the present review explores the role of DES in bioactive compounds extraction from food waste. Various extraction processes using the DES system are thoroughly studied and the application of bioactive components as antioxidants, antimicrobials, flavourings, nutraceuticals, functional ingredients, additives, and preservatives is investigated. Most importantly, regulatory considerations and safety aspects of DES in food applications are discussed in-depth along with consumer perception and acceptance of DES in the food sector. The key hypothesis of the review is to evaluate emerging DES systems for their efficiency in bioactive extraction technologies and various food applications. Overall, this review provides a comprehensive understanding of utilizing DES for synthesizing valuable food waste-derived bioactive components, offering a sustainable approach to waste management and the development of high-value products., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)