33 results on '"Stone, John"'
Search Results
2. Fibrotic phenotype of IgG4-related disease
- Author
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Lanzillotta, Marco, Culver, Emma, Sharma, Amita, Zen, Yoh, Zhang, Wen, Stone, John H, and Della-Torre, Emanuel
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- 2024
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3. Granzyme K– and amphiregulin-expressing cytotoxic T cells and activated extrafollicular B cells are potential drivers of IgG4-related disease
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Koga, Risako, Maehara, Takashi, Aoyagi, Ryuichi, Munemura, Ryusuke, Murakami, Yuka, Doi, Atsushi, Kono, Michihito, Yamamoto, Hidetaka, Niiro, Hiroaki, Kiyoshima, Tamotsu, Tanabe, Mika, Nakano, Toshiaki, Matsukuma, Yuta, Kawano, Mitsuhiro, Stone, John H., Pillai, Shiv, Nakamura, Seiji, and Kawano, Shintaro
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- 2024
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4. Qualitative interviews to support development of a patient-reported companion measure to the Glucocorticoid Toxicity Index
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Howell, Timothy A., Matza, Louis S., Stone, John H., Gelinas, Deborah, Stone, Martha N., Rao, Vijayaraghava T.S., and Phillips, Glenn A.
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- 2024
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5. Diagnosis and management of ANCA-associated vasculitis
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Kronbichler, Andreas, Bajema, Ingeborg M, Bruchfeld, Annette, Mastroianni Kirsztajn, Gianna, and Stone, John H
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- 2024
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6. WED-152 Design and study population of MITIGATE: the first multinational randomized controlled clinical trial in IgG4 related disease, evaluating the efficacy and safety of the CD19 B cell depleting agent inebilizumab
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Stone, John, primary, Culver, Emma, additional, Khosroshahi, Arezou, additional, Zhang, Wen, additional, Torre, Emanuel Della, additional, Okazaki, Kazuichi, additional, Tanaka, Yoshiya, additional, Lohr, Matthias, additional, Schleinitz, Nicolas, additional, Dong, Lingli, additional, Umehara, Hisanori, additional, Lanzillotta, Marco, additional, Wallace, Zachary, additional, Ebbo, Mikael, additional, Webster, George, additional, Wu, Yanping, additional, Cimbora, Daniel, additional, and Rampal, Nishi, additional
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- 2024
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7. Preparatory Check to Assess Equipment and Participant Comfort Prior to a Televisit in Huntington’s Disease (P6-3.010)
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Frank, Samuel, primary, Stone, John, additional, Kimmerly, Jason, additional, Kayson, Elise, additional, Goldstein, Jody, additional, and Auinger, Peggy, additional
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- 2024
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8. Real-world Reduction in Oral Corticosteroid Utilization Following Efgartigimod Initiation in Patients Living with Generalized Myasthenia Gravis (S38.002)
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Goyal, Neelam, primary, Qi, Cynthia, additional, Stone, John, additional, Gelinas, Deborah, additional, Jefferson, Matthew, additional, Suthagar, Tharun Balaji, additional, Menon, Rohit R., additional, Goyal, Amit, additional, and Phillips, Glenn, additional
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- 2024
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9. Multimodality Imaging Features of Immunoglobulin G4–related Vessel Involvement
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O’Shea, Aileen, primary, Crotty, Rory K., additional, Randhawa, Mangun Kaur, additional, Oliveira, George, additional, Perugino, Cory A., additional, Stone, John H., additional, Harisinghani, Mukesh G., additional, Wallace, Zachary S., additional, and Hedgire, Sandeep S., additional
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- 2024
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10. Celebrating progress in the vasculitides, old and new
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Stone, John H, primary
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- 2024
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11. Othello Goes to Lisbon, 1765
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Stone, John, primary
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- 2024
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12. Antisynthetase Syndrome Causing Necrotizing Myositis Involving Extraocular Muscles.
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Lin, Lisa Y., Azad, Amee D., Chiou, Carolina A., Kozanno, Liana, Stemmer-Rachamimov, Anat, Stone, John, and Lee, Nahyoung Grace
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- 2024
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13. The role of statin therapy in older adults: best practices and unmet challenges.
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Stone, John, Kumar, Manish, and Orkaby, Ariela R.
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CARDIOVASCULAR diseases ,OLDER people ,STATINS (Cardiovascular agents) ,LITERATURE reviews ,EVIDENCE gaps ,DRUG monitoring - Abstract
Cardiovascular disease (CVD) is associated with significant morbidity, functional decline, and mortality in older adults. The role of statins for primary CVD prevention in older adults remains unclear, largely due to systematic exclusion of these individuals in trials that inform current practice guidelines, leading to conflicting national and international practice recommendations for statin use for primary prevention of CVD in adults aged 75 and older. In this narrative review, we performed a literature review utilizing PubMed, and ultimately focus on seven major national and international guidelines of lipid lowering therapy. Through the lens of two clinical cases, we review physiologic changes in lipid metabolism with aging, discuss the relationship between cholesterol and cardiovascular events in older adults, examine the national and international guidelines and the available evidence informing these guidelines for statin use in primary prevention of CVD in older adults. Finally we review practical clinical considerations for drug monitoring and deprescribing in this population. Guidelines for the use of statins for primary CVD prevention in older adults is conflicting. Collectively, evidence to date suggests statin therapy may be beneficial for primary CVD prevention in older adults free of life-limiting comorbidities. Randomized controlled trials are currently underway to address current evidence gaps. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Dynamics of chromosome organization in a minimal bacterial cell
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Gilbert, Benjamin R., primary, Thornburg, Zane R., additional, Brier, Troy A., additional, Stevens, Jan A., additional, Grunewald, Fabian, additional, Stone, John E., additional, Marrink, Siewert J., additional, and Luthey-Schulten, Zaida, additional
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- 2024
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15. Painting a New Bootstripe Like a Pro: A do-it-yourself jig helps ensure your bootstripe doesn't appear to sag at the bow or stern.
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STONE, JOHN
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DO-it-yourself work ,BOATYARDS ,VISUAL training - Abstract
This article from Practical Sailor offers a comprehensive guide on how to paint a bootstripe on a boat. The author emphasizes the need for a DIY jig to ensure a level and proportional bootstripe, taking into account the hull's outward flare. The article also explores the aesthetic considerations in choosing the width and color of the bootstripe, as well as the practical advantages it offers, such as protecting the topside paint and enhancing the boat's appearance. The author provides detailed instructions on creating and using the DIY jig, along with tips for marking and taping off the bootstripe. [Extracted from the article]
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- 2024
16. Hard Lessons from Hurricane Florence.
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STONE, JOHN
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HURRICANE Florence, 2018 ,DOCKS ,RAINFALL ,STORM damage ,BODIES of water ,FORTUNE - Abstract
This article from Practical Sailor recounts the author's experience preparing their boat, the Far Reach, for Hurricane Florence in 2018. The author and their wife made the decision to keep their boat in the marina and took several precautions to secure it, including doubling up on dock lines and using chafe guards. Despite the destruction in the marina, the Far Reach survived the storm without damage. The article emphasizes the importance of proactive preparation, having a marina action plan, and developing relationships with neighboring boat owners. [Extracted from the article]
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- 2024
17. New Seacocks for the Offshore Sailor.
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STONE, JOHN
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BOAT maintenance & repair ,INDUSTRIALIZED building ,BRONZE - Abstract
The article discusses the installation of the Groco IBVF, a new style multi-component bronze seacock system. The author found that the IBVF system was a more affordable and reliable option compared to traditional bronze seacocks. The article provides a detailed description of the IBVF system, the process of removing old through-hull fittings and seacocks, and the installation of the new system. The IBVF system exceeds the strength standards recommended by the American Boat and Yacht Council (ABYC). The article discusses the advantages of the IBVF seacock system, which allows for easy servicing and replacement of the valve assembly without removing the flange base or through-hull. The author replaced their Spartan Marine seacocks with the Groco IBVF seacock system and also replaced the plywood backing plates with G-10, a flame-retardant epoxy resin with fiberglass fabric reinforcement. The article provides a step-by-step description of the installation process and concludes that the IBVF seacock system is a good alternative to traditional bronze seacocks. [Extracted from the article]
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- 2024
18. Chapter 19 - IgG4-related disease
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Stone, John H.
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- 2024
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19. Chapter 3 - A very public responsibility: Governing public transport in the COVID-19 pandemic
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Stone, John and Chong, Yoong Wai
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- 2024
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20. 249 - The Systemic Vasculitides
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Stone, John H.
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- 2024
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21. The Scraper-only Approach to Bottom Paint Removal.
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STONE, JOHN
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ROTATOR cuff ,ANTIFOULING paint - Abstract
This article from Practical Sailor discusses the process of removing bottom paint from a boat. The author explores different methods of paint removal, including sanding, chemical strippers, and professional media blasting. The author then describes their own experience using a scraper as the primary means of removing the paint, which they found to be effective and less time-consuming than sanding. They provide tips and techniques for using a scraper and emphasize the importance of safety precautions. The article concludes by recommending that readers try different methods and choose the one that works best for them. [Extracted from the article]
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- 2024
22. List of contributors
- Author
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Abell, Thomas, Acosta, Camilo J., Adadey, Samuel Mawuli, Anaya, Juan-Manuel, Annibale, Bruno, Antonini, Simone, Aqeel, Faten, Arepalli, Sruthi, Assassi, Shervin, Babushok, Daria V., Barkin, Jodie A., Bartalena, Luigi, Ben Nasr, Moufida, Berentsen, Sigbjørn, Betterle, Corrado, Birtolo, Maria Francesca, Bisarya, Pooja Nikki, Blüml, Stephan, Bonomi, Marco, Bowlus, Christopher L., Brassard, Alain, Brusch, Anna, Burrone, Marco, Carrillo-Bayona, Jorge Alberto, Casciola-Rosen, Livia, Caturegli, Patrizio, Chang, Christopher, Chatzis, Loukas, Chaves, Juan José, Chen, Dhruti P., Chen, Jingjing, Chen, Saijuan, Cheng, Wenyan, Chhabra, Garvit, Choi, Jamie H., Cianferotti, Luisella, Crowell, Eric, Cuda, Carla M., Davidson, Anne, Deane, Sean, del Carmen Moleon, Maria, Di Dalmazi, Giulia, Dilaghi, Emanuele, Dixon Johns, James, Doost, Mohammad Saffari, Dyke, Jason, D’Addio, Francesca, D’Cruz, David P., Falk, Ronald J., Farina, Antonio, Fattizzo, Bruno, Fernandez-Carbonell, Cristina, Fiorina, Paolo, Flanagan, Eoin P., Franzen, Daniel P., Frederiksen, Henrik, Free, Meghan E., Frejo, Lidia, Fung, Maxwell A., Gaffney, Patrick M., Galindo, Javier Leonardo, Gallo, Daniela, Gately, Ursula, Geetha, Duvuru, Gershwin, M. Eric, Goldbach-Mansky, Raphaela, Goronzy, Jörg J., Goules, Andreas V., Gudjonsson, Johann E., Guilherme, Luiza, Guo, Weinan, Hajj-Ali, Rula A., Hamburger, Nicole, He, Liting, Herrán, María, Hoa, Michael, Honnorat, Jérôme, Hu, Qingjie, Hu, Yue, Husebye, Eystein S., Ippolito, Silvia, James, Eddie A., James, Judith A., Jennette, J. Charles, Jian, Zhe, Jiang, Ying, Kaklamanos, Aimilios, Kalil, Jorge, Kaminski, Henry J., Kammeyer, Ryan, Kaya, Ziya, Kelly, Jennifer A., Khakoo, Nidah Shabbir, Khoury, Samia J., Kolios, Antonios G.A., Königs, Christoph, Kopplin, Laura J., Krupp, Lauren B., Kuker, Russ, Kwapnoski, Zachary, Kyttaris, Vasileios C., La Cava, Antonio, Lahner, Edith, Lania, Andrea G., Lehmann, Helmar C., Levy, Cynthia, Li, Chunying, Li, Kun, Li, Shuli, Li, Xiangqian, Liu, Hui, Liu, Ling, Liu, Yudong, Lleo, Ana, Long, Hai, Lopez-Escamez, Jose A., Lu, Qianjin, Lunati, Maria Elena, Lunn, Michael P.T., Lupi, Isabella, Malattia, Clara, Maletic-Savatic, Mirjana, Marietta, Eric V., Martin, Cole, Martini, Alberto, Mastaglia, Frank, Mathur, Prateek, Mazziotti, Gherardo, McDonald, Benjamin, Mehta, Neesurg S., Mieli-Vergani, Giorgina, Milano, Reza V., Morel, Laurence, Moss, Brandon, Moussa, Kareem, Murray, Joseph A., Naing, LeYu, Needham, Merrilee, Nelson, Andrew J., Nilsson, Jakob, O'Neill, Kimberly A., Ochoa, Jorge R., Öztosun, Gülşen, Pan, Meng, Paramalingam, Shereen, Pathak, Shresh, Pei, Chenchen, Perl, Andras, Perlman, Harris, Persani, Luca, Pillai, Shiv, Piquet, Amanda L., Poddubnyy, Denis, Polo, Fernando, Presotto, Fabio, Rabb, Hamid, Radin, Massimo, Rochat, Pete, Rodolfi, Stefano, Rojas, Manuel, Rosen, Antony, Rossetti, Raffaella, Rubin, David T., Saab, Georges, Sabbadin, Chiara, Salbach, Christian, Schreiber, Karen, Sciascia, Savino, Sheikh, Kazim A., Shen, Yang, Shusko, Alexander R., Sieper, Joachim, Smilek, Dawn Elaine, Smith, Kenneth, Smolen, Josef S., Sorkhabi, Sharareh Yousefpour, Stocker, Abigail, Stone, John H., Stroikova, Vera, Sun, Yonghu, Syrbe, Uta, Tanda, Maria Laura, Taubenslag, Kenneth J., Terziroli Beretta-Piccoli, Benedetta, Tessneer, Kandice L., Thakolwiboon, Smathorn, Tian, Jingru, Tiniakou, Eleni, Titulaer, Maarten J., Tsui, Edmund, Tzioufas, Athanasios G., Vambutas, Andrea, van Steenhoven, Robin W., Varga, John, Vergani, Diego, Villagrán-García, Macarena, Vondenberg, Jaime A., Vora, Paras, Wagner, Catriona A., Wang, Gang, Wang, Jingying, Wang, Min, Wang, Xin, Weinstein, Jessica E., Weyand, Cornelia M., Xin, Yue, Xing, Enze, Yao, Xu, Yu, Cong, Zhang, Furen, Zhang, Jianzhong, Zhang, Xuan, Zhou, Cheng, Zhu, Haiqin, Zhu, Hong, Zinger, Adar, and Zuo, Xiaoxia
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- 2024
- Full Text
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23. Contributors
- Author
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Abrams, Charles S., Adler, Ronald S., Agarwal, Anupam, Akin, Cem, Aksamit, Allen J., Jr., Al-Awqati, Qais, Allen, Upton D., Allos, Ban Mishu, Angus, Derek C., Appelbaum, Frederick R., Armitage, James O., Armstrong, April W., Armstrong, Deborah K., Arnaout, M. Amin, Arnold, Robert M., Aronson, Louise, Atkinson, John P., Attia, Evelyn, Auerbach, Andrew D., Ayanian, John Z., Baddour, Larry M., Baden, Lindsey R., Bailey, Thomas C., Bain, Barbara J., Bajorin, Dean F., Baloh, Robert W., Bangham, Charles R.M., Barasch, Jonathan, Barrett, Bruce, Bartholomew, John R., Bartleson, J.D., Barton, Mary B., Basner, Robert C., Bass, Adam J., Bass, Anne R., Bauman, Julie E., Bausch, Daniel G., Bayer, Arnold S., Bazarian, Jeffrey J., Bearman, Gonzalo M., Becker, Richard C., Beckham, J. David, Beckman, Joshua A., Beigel, John H., Bel, Elisabeth H., Belda, Walter, Jr., Benarroch, Eduardo E., Berger, Joseph R., Berliner, Nancy, Bernat, James L., Bessesen, Daniel H., Bibbins-Domingo, Kirsten, Biesecker, Leslie G., Biundo, Joseph J., Blankson, Joel N., Bloch, Karen C., Blom, Henk J., Boden, William E., Boivin, Guy, Bolognia, Jean, Bonomo, Robert A., Booth, Sarah L., Bosaeus, Ingvar G., Brenner, David J., Bridges, S. Louis, Jr., Brochard, Laurent, Brodsky, Robert A., Brook, Itzhak, Brown, Jennifer R., Brunetti, Enrico, Bryant, Amy E., Budge, Philip J., Buffet, Pierre A., Bushinsky, David A., Bykerk, Vivian P., Calabresi, Peter A., Calello, Diane P., Calfee, David P., Callahan, S. Todd, Camilleri, Michael, Canoso, Juan J., Cappellini, Maria Domenica, Carabello, Blase A., Carucci, Laura R., Castells, Mariana, Catherino, William H., Cederholm, Tommy E., Chalasani, Naga P., Chambers, Henry F., Chang, Larry W., Chang, Lin, Chao, Nelson J., Chatterjee, Mitali, Chaturvedi, Seemant, Chen, Lin H., C-A Chen, Sharon, Chon, Susan Y., Christiani, David C., Chu, Edward, Cieslak, Theodore J., Cioffi, George A., Clancy, Carolyn M., Clauss, Heather, Clauw, Daniel J., Clemmons, David R., Coffman, Thomas M., Cohen, David, Cohen, Jeffrey, Cohen, Myron S., Cohen, Steven P., Connors, Joseph M., Cook, Deborah J., Cook, Lucy B.M., Cooney, Kathleen A., Craigen, William J., Crandall, Jill P., Croft, Simon L., Crow, Mary K., Crump, John A., Cudkowicz, Merit E., Cunningham-Rundles, Charlotte, Dahir, Kathryn M., Damon, Inger K., Daras, Michael, Dart, Richard C., Davidson, Nancy E., Deane, Kevin D., DeAngelis, Lisa M., DeCamp, Malcolm M., DeLoughery, Thomas G., Rio, Carlos del, De Luca, Gabriele C., Denning, David W., Deuster, Patricia A., DeZern, Amy E., Dhatariya, Ketan K., Diasio, Robert B., Diemert, David J., Digre, Kathleen B., Dilsizian, Vasken, Dionne, Jodie A., Di Paola, Jorge, Dispenzieri, Angela, Dogra, Sunil, Doroshow, James H., Douglas, John M., Jr., Drazen, Jeffrey M., Drekonja, Dimitri, Dubberke, Erik R., DuBeau, Catherine E., Dumler, J. Stephen, Duvic, Madeleine, Ebi, Kristie, Edwards, Kathryn M., Edwards, N. Lawrence, Eikelboom, John W., Einhorn, Lawrence H., Elliott, Perry M., Emanuel, Ezekiel J., Falagas, Matthew E., Falk, Gary W., Fang, James C., Farley, Monica M., Feder, Gene, Feller-Kopman, David J., McDonald File, Thomas, Jr., Fishman, Glenn I., Flack, John M., Fleckenstein, James M., Fleisher, Lee A., Flint, Paul W., Fogel, Evan L., Fontana, Robert J., Forsmark, Chris E., Fournier, Pierre-Edouard, Fowler, Vance G., Jr., Franco, Manuel A., Fraser, Victoria J., Freeman, Roy, Freund, Karen M., Froberg, Blake A., Gallagher, Patrick G., Gandhi, Monica, Gandhi, Rajesh T., Ganz, Leonard, Garan, Hasan, Garcia-Tsao, Guadalupe, Geisler, William M., Gelfand, Joel M., George, Tony P., Gepstein, Lior, Gertz, Morie A., Ghanem, Khalil G., Gharavi, Ali G., Ghossein, Cybele, Gill, Christopher J., Ginsburg, Geoffrey S., Glesby, Marshall J., Gnann, John W., Jr., Goldman, David L., Goldman, Lee, Goldstein, Larry B., Gordon, Anthony C., Gotlib, Jason, Gotuzzo, Eduardo, Grasemann, Hartmut, Green-McKenzie, Judith, Greenberg, Harry B., Greenberg, Steven A., Greer, David M., Greysen, S. Ryan, Griffin, Marie R., Griggs, Robert C., Grossman, Daniel, Guay-Woodford, Lisa M., Gulick, Roy M., Haake, David A., Hagman, Melissa M., Hagspiel, Klaus D., Harris, Raymond C., Havers, Fiona P., Heath, Elisabeth I., Hecht, Frederick M., Hensrud, Donald D., Hess, Jeremy, Hewlett, Erik L., Hift, Richard J., Hill, David R., Hill, Nicholas S., Hillyer, Christopher D., Hirsch, Hans H., Hoeper, Marius M., Hoit, Brian D., Holers, V. Michael, Holland, Steven M., Hollenberg, Anthony N., Hollenberg, Steven M., Howard, Jo, Hunter, David J., Hussain, Khalid, Iannuzzi, Michael C., Inman, Robert D., Inouye, Sharon K., Ison, Michael G., Jen, Joanna C., Jensen, Dennis M., Jensen, Michael D., Jensen, Robert T., Johnston, S. Claiborne, Jones, Robin L., Jordan, Richard C., Kahi, Charles J., Kaiser, Laurent, Kaminski, Henry J., Kamya, Moses R., Kao, Louise W., Kaplan, Steven A., Kastner, Daniel L., Katzka, David A., Katzman, Debra K., Kaushansky, Kenneth, Kaye, Keith S., Keating, Armand, Kelley, Robin K., Kennedy, Richard B., Khuri, Fadlo R., Kim, Rose, Kirchhoff, Louis V., Kirking, Hannah, Kirtane, Ajay J., Kishnani, Priya S., Klausner, Jeffrey D., Klion, Amy D., Klompas, Michael, Knopman, David S., Ko, Christine J., Kodali, Susheel, Kontoyiannis, Dimitrios P., Koppel, Barbara S., Korenblat, Kevin M., Korf, Bruce R., Kortepeter, Mark G., Koshy, Anita A., Kottilil, Shyamasundaran, Kovacs, Joseph A., Kovacs, Thomas O., Kowdley, Kris V., Kraft, Monica, Kramer, Christopher M., Krasnewich, Donna M., Kraus, William E., Krause, Peter J., Kroger, Andrew T., Kroshinsky, Daniela, Kuemmerle, John F., Kuipers, Ernst J., Kutner, Jean S., Laheru, Daniel, Lampert, Rachel, Landefeld, C. Seth, Landovitz, Raphael J., Landry, Donald W., Lange, Richard A., Lee, Hochang B., Lee, Nelson, Levey, Andrew S., Levine, Stephanie M., Lichtenstein, Gary R., Liebmann, Jeffrey M., Liebschutz, Jane M., Lim, Henry W., Lima, Aldo A.M., Limaye, Ajit P., Limdi, Nita A., Link, Mark S., Liu, Catherine, Lloyd-Jones, Donald M., Lopez, Fred A., Louie, Arnold, Lyness, Jeffrey M., MacKenzie, C. Ronald, MacLennan, Calman A., MacMillan, Harriet L., Madoff, Robert D., Maher, Jacquelyn, Maier, Lisa A., Maldarelli, Frank, Malhotra, Atul, Manary, Mark J., Marcos, Luis A., Marelli, Ariane J., Marks, Andrew R., Marschall, Jonas, Martin, Paul, Martinez, Fernando J., Mason, Joel B., Masur, Henry, Mathers, Amy J., Matthay, Michael A., McCool, F. Dennis, McInnes, Iain B., McLaughlin, Vallerie, McMichael, Amy, McMurray, John J.V., McQuaid, Kenneth R., Mead, Paul S., Means, Robert T., Jr., Melia, Michael T., Mellinghoff, Ingo K., Melton, Genevieve B., Merrick, Samuel T., Miceli, Marisa H., Michel, Marc, Mokdad, Ali H., Moy, Ernest, Mukherjee, Debabrata, Murr, Andrew H., Myerburg, Robert J., Nadeau, Kari C., Nath, Avindra, Neal-Perry, Genevieve, Neilson, Eric G., Nelson, Christina A., Nelson, David B., Nelson, Lewis S., Nestler, Eric J., Neuzil, Kathleen M., Nieman, Lynnette K., Niven, Alexander S., O’Connor, Christopher M., O’Connor, Francis G., O’Connor, Patrick G., O’Donnell, Anne E., O’Donnell, James S., Oh, Jae K., Okun, Michael S., O’Leary, Sean T., Olgin, Jeffrey E., Olivier, Kenneth N., Olivotto, Iacopo, Olsen, Nancy J., Orenstein, Walter A., Ortel, Thomas L., O’Shea, John J., Osmon, Douglas R., Ostrem, Jill L., Ostrosky-Zeichner, Luis, Otto, Catherine M., Ottolini, Martin G., Ovsyannikova, Inna G., Pappas, Peter G., Park, Ben Ho, Patel, Robin, Patterson, Thomas F., Pawlotsky, Jean-Michel, Payne, Thomas H., Pearce, Elizabeth N., Pearson, Richard D., Perl, Trish M., Petersen, Brett W., Petri, William A., Jr., Pfeffer, Marc A., Philips, Jennifer A., Pisetsky, David S., Pletcher, Steven D., Plumb, Ian D., Poland, Gregory A., Powell, Frank, Pyeritz, Reed E., Quinn, Thomas C., Racaniello, Vincent, Radhakrishnan, Jai, Radich, Jerald, Rafailidis, Petros I., Raghu, Ganesh, Ragni, Margaret V., Rahman, Proton, Rajkumar, S. Vincent, Ralston, Stuart H., Raoult, Didier, Reboli, Annette C., Reddy, K. Rajender, Redelmeier, Donald A., Redlich, Carrie A., Reilly, John, Reller, Megan E., Reno, Hilary E.L., Resnick, Neil M., Rice, Louis B., Roach, E. Steve, Robinson, Jennifer G., Rogatsky, Inez, Rogers, Joseph G., Rolain, Jean-Marc, Rollins, Barrett J., Romero, José R., Rosen, Jennifer B., Rosenthal, Philip J., Russell, James A., Rustgi, Anil K., Safer, Joshua D., Saini, Sarbjit S., Salmon, Jane E., Salvana, Edsel Maurice T., Santoro, Nanette, Santucci, Peter A., Sarnak, Mark J., Savage, Kerry J., Savard, Patrice, Sawka, Michael N., Scanlon, Paul D., Schafer, Andrew I., Schiff, Manuel, Schilsky, Michael L., Schneider, Thomas Rudolf, Schooley, Robert T., Schriger, David L., Schuchter, Lynn M., Schwartz, Lawrence B., Seas, Carlos, Seifert, Steven A., Seifter, Julian Lawrence, Selcen, Duygu, Selim, Magdy, Semrad, Carol E., Sepulveda, Jorge, Shaw, Pamela J., Shaz, Beth H., Sheridan, Robert L., Sherman, Stuart, Shojania, Kaveh G., Shopsin, Bo, Shy, Michael E., Sidransky, Ellen, Sifri, Costi D., Siliciano, Robert F., Simel, David L., Skorecki, Karl, Slawski, Barbara A., Slutsky, Arthur S., Smetana, Gerald W., Smith, A. Gordon, Smith, Stephen R., Southwick, Frederick S., Spiegel, Allen M., Spiera, Robert, Spinola, Stanley M., Spong, Catherine Y., Stabler, Sally P., Stark, Paul, St. Clair, E. William, Steiner, Theodore S., Stephens, David S., Stevens, David A., Stevens, Dennis L., Stokes, M. Barry, Stoller, James K., Stone, John H., Stone, Richard M., Su, Edwin P., Swerdloff, Ronald S., Swygard, Heidi, Sykes, Megan, Talbot, H. Keipp, Tamimi, Rulla M., Tanofsky-Kraff, Marian, Tarlo, Susan M., Taylor, Stephanie N., Teirstein, Paul S., Telford, Sam R., III, Thakker, Rajesh V., Therrien, Judith, Thompson, George R., III, Tormoehlen, Laura, Tosti, Antonella, Trehan, Indi, Umpierrez, Guillermo E., Valeri, Anthony Michael, Varga, John, Vaughn, Bradley V., Venook, Alan P., Verbalis, Joseph G., Vose, Julie M., Wachter, Robert M., Walsh, B. Timothy, Walsh, Edward E., Walsh, Thomas J., Walston, Jeremy D., Walter, Roland B., Wang, Christina, Wang, Kenneth K., Ware, Lorraine B., Warren, Cirle A., Watkins, Paul B., Weber, Thomas J., Weimer, Louis H., Weinberg, Geoffrey A., Weinstein, Robert S., Weiss, Roger D., Weiss, Roy E., Weitz, Jeffrey I., Welt, Frederick G.P., Wenzel, Richard P., Werth, Victoria P., West, Sterling G., White, A. Clinton, Jr., White, Christopher J., White, Julian, White, Perrin C., Whitley, Richard J., Whyte, Michael P., Wiebe, Samuel, Wiener-Kronish, Jeanine P., Wilber, David J., Wilcox, Mark H., Winikoff, Beverly, Winter, Jane N., Wittink, Marsha N., Wolff, Tracy A., Wolin, Edward M., Wormser, Gary P., Yancy, Clyde W., Young, Neal S., Young, Vincent B., Young, William F., Jr., Yu, Alan S.L., Zimetbaum, Peter, and Zucker, Jane R.
- Published
- 2024
- Full Text
- View/download PDF
24. Revolutinising power conversion in the railway industry with GaN and SiC technologies.
- Author
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Stone, John
- Subjects
GALLIUM nitride ,PHOTOVOLTAIC power systems ,RAILROADS ,ELECTRICAL conductivity transitions ,POWER resources ,WIDE gap semiconductors ,RAILROAD finance - Abstract
This article discusses the use of Gallium Nitride (GaN) and Silicon Carbide (SiC) technologies in the railway industry for power conversion systems. GaN and SiC are wide-bandgap semiconductors known for their superior properties such as high efficiency, compact form-factor, rapid switching, high-voltage operation, and thermal endurance. These technologies offer advantages over traditional silicon-based semiconductors, including enhanced efficiency, smaller size, and higher power density. The article also mentions the potential of GaN technology in RF and communication systems, electric mobility, and energy-related applications. The ALL2GaN project is highlighted as an initiative to harness GaN's potential in various sectors, including railway applications, with a focus on affordability and eco-friendliness. SiC technology is also discussed, with examples of SiC-based products for power conversion efficiency in railway applications. Relec Electronics is mentioned as a UK partner of Premium PSU, offering a portfolio of high-performance, rugged power supplies and converters for the railway industry. [Extracted from the article]
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- 2024
25. Contributors
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Arai, Takuro, Behrens, Roger, Boonsiripant, Saroch, Bruwer, Megan, Bruzzone, Francesco, Burke, Matthew, Cavallaro, Federico, Chong, Yoong Wai, Circella, Giovanni, Corazza, Maria Vittoria, de Séjournet, Alice, Emberger, Guenter, Foltýnová, Hana Brůhová, Freer, David, Gulhare, Siddhartha, He, Le, Hsu, Yu-Ting, Imran, Muhammad, Isildar, Hilal Tulan, Jittrapirom, Peraphan, Kaminagai, Yo, Khodke, Aditi, Kostka, Leo, Lemmerer, Helmut, Lopes d'Azevedo, Stéphanie, Macharis, Cathy, McLachlan, Nico, Mulley, Corinne, Nelson, John D., Nocera, Silvio, Ocalir, Ebru Vesile, Oszter, Vilmos, Pedro, Mathilde, Pejdo, Ana, Rebillon, Gurvann, Shao, Yongzhen, Shibayama, Takeru, Shih, Hsin-Cheng, Siewwuttanagul, Somsiri, Stone, John, Suzuki, Sachi, Tan, Liyue, Taniguchi, Ayako, Tori, Sara, Wang, Yacan, Whale, Jonty, Wijaya, Kenny Chandra, Yun, Daun, and Zhou, Huiyu
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- 2024
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26. IgG4-related disease: Advances in the diagnosis and treatment
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Brito-Zerón, Pilar, Bosch, Xavier, Ramos-Casals, Manuel, and Stone, John H.
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IgG4-related disease is a rare immune-mediated systemic disease with the capability of involving essentially any organ. Although the presenting clinical features vary substantially according to the speciality to which patients present first, perhaps the most common clinical presentation is that of single or multiple organ enlargement, arousing suspicion of cancer. The disease is frequently diagnosed unexpectedly in pathological specimens or on imaging studies. The diagnostic approach is complex and includes not only IgG4-related tests (serum levels, circulating plasmablasts, and specific immunohistochemical studies), but also clinical, laboratory, and imaging tests as well as the typical histopathological features (lymphocytic infiltration, storiform fibrosis, eosinophilic infiltration, and obliterative phlebitis). IgG4-related tests should not be considered as diagnostic in the absence of an appropriate clinical scenario. Therapeutic approaches reported to date pertain primarily to glucocorticoids, but the use of these medications has not been studied in a controlled or prospective manner. The most current investigational treatment approaches have focused on targeting cells of the B-cell lineage, including B-cell-depleting agents (rituximab) and a non-depleting homodimer monoclonal antibody targeting CD19 and Fc-gamma RIIIb.
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- 2024
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27. Multiorgan involvement and circulating IgG1 predict hypocomplementaemia in IgG4-related disease.
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Katz G, Perugino C, Wallace ZS, Jiang B, Guy T, McMahon GA, Jha I, Zhang Y, Liu H, Fernandes AD, Pillai SS, Atkinson JP, Kim AH, and Stone JH
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Objectives: Hypocomplementaemia is common in patients with IgG4-related disease (IgG4-RD). We aimed to determine the IgG4-RD features associated with hypocomplementaemia and investigate mechanisms of complement activation in this disease., Methods: We performed a single-centre cross-sectional study of 279 patients who fulfilled the IgG4-RD classification criteria, using unadjusted and multivariable-adjusted logistic regression to identify factors associated with hypocomplementaemia., Results: Hypocomplementaemia was observed in 90 (32%) patients. In the unadjusted model, the number of organs involved (OR 1.42, 95% CI 1.23 to 1.63) and involvement of the lymph nodes (OR 3.87, 95% CI 2.19 to 6.86), lungs (OR 3.81, 95% CI 2.10 to 6.89), pancreas (OR 1.66, 95% CI 1.001 to 2.76), liver (OR 2.73, 95% CI 1.17 to 6.36) and kidneys (OR 2.48, 95% CI 1.47 to 4.18) were each associated with hypocomplementaemia. After adjusting for age, sex and number of organs involved, only lymph node (OR 2.59, 95% CI 1.36 to 4.91) and lung (OR 2.56, 95% CI 1.35 to 4.89) involvement remained associated with hypocomplementaemia while the association with renal involvement was attenuated (OR 1.6, 95% CI 0.92 to 2.98). Fibrotic disease manifestations (OR 0.43, 95% CI 0.21 to 0.87) and lacrimal gland involvement (OR 0.53, 95% CI 0.28 to 0.999) were inversely associated with hypocomplementaemia in the adjusted analysis. Hypocomplementaemia was associated with higher concentrations of all IgG subclasses and IgE (all p<0.05). After adjusting for serum IgG1 and IgG3, only IgG1 but not IgG4 remained strongly associated with hypocomplementaemia., Conclusions: Hypocomplementaemia in IgG4-RD is not unique to patients with renal involvement and may reflect the extent of disease. IgG1 independently correlates with hypocomplementaemia in IgG4-RD, but IgG4 does not. Complement activation is likely involved in IgG4-RD pathophysiology., Competing Interests: Competing interests: The authors declare competing interests with the Rheumatology Research Foundation, NIH, Sanofi, Zenas, Amgen, Genentech, Sana, National Multiple Sclerosis Society, GlaxoSmithKline, Helmsley Charitable Trust, AstraZeneca, Bristol Myers Squibb, Novartis, Alexion Pharmaceuticals, ANI Pharmaceuticals, Aurinia Pharmaceuticals, Exagen Diagnostics, Kypha, Pfizer, UpToDate, The Rheumatology Education Group, Lupus Foundation of America-Heartland Chapter, St Louis Rheumatology Chapter, Lupus Research Alliance, National Scleroderma Foundation, AbbVie, Acepodia, Alpine Immune Sciences, Argenx, Connect Biopharma, CTI BioPharma, Horizon Therapeutics, iCell Gene Therapeutics, IQVIA, Prometheus Biosciences/Merck, Q32 Bio, Salvina Therapeutics, IgG4ward! Foundation, Achillion Pharmaceuticals, Annexon Pharmaceuticals, Arrowhead Pharmaceuticals, Autobahn Therapeutics, Avidity Partners, BioMarin Pharmaceuticals, Broadwing Bio, Celldex Therapeutics, 4D Molecular Therapeutics, HiBIO, Janssen, Kypha, Merck KGaA, Takeda Pharmaceuticals, Compliment Corporation, Gemini Therapeutics, Leducq Foundation, Be Bio Pharma, Paratus, Octagon Therapeutics, Ab Pro, Viela Bio, MedPace and BioCryst., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ on behalf of EULAR.)
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- 2024
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28. Real-world application of the pediatric Glucocorticoid Toxicity Index in childhood-onset lupus.
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Zhang E, Capponi S, Scobell R, Alonzi G, Hlobik M, Daga A, Meidan E, Wobma H, Kim L, Henderson LA, Case S, Nigrovic PA, Stone JH, Costenbader KH, Son MBF, and Chang JC
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Objectives: The pediatric Glucocorticoid Toxicity Index (pGTI) is a new, pediatric-specific tool to quantify glucocorticoid (GC)-related morbidity in children. We evaluated the feasibility and construct validity of retrospective pGTI scoring in patients with pediatric-onset systemic lupus erythematosus (pSLE) and identified risk factors for cumulative toxicity., Methods: We conducted a retrospective cohort study of patients with pSLE treated with GCs at two pediatric centers (1999-2023). GC exposure was estimated using interval-averaged oral prednisone-equivalent dose and cumulative prednisone-equivalent dose. We scored change in GC toxicity every 6 months (±2) using a modified pGTI including 7 of 10 domains. We calculated the Cumulative Worsening Score (CWS), a continuous summation of toxicity accrued. Mixed effects linear regression was used to identify factors associated with CWS., Results: There were 126 patients with pSLE, including 88 with nephritis, with a median of 6 visits/patient. Nearly half (47 %) experienced toxicity in the Blood Pressure domain. Other common toxicities were mood disturbance (25 %), followed by increased body mass index (BMI), striae, and sleep disturbance (21 % each). Decreased growth velocity was observed in 18 %. There was modest correlation between cumulative GC dose and CWS (rho 0.3; p < 0.01). Greater cumulative toxicity was associated with younger age, elevated BMI, and rituximab use at the time of GC initiation, albeit indications for the latter were not captured., Conclusions: Patients with pSLE experience a high burden of GC toxicity, particularly related to blood pressure, BMI, sleep, and growth. Standardized, pediatric-specific GC toxicity assessment is feasible in real-world settings and can facilitate evaluation of strategies to reduce morbidity in children requiring chronic GC treatment., Competing Interests: Declaration of competing interest J.C.C previously received grant funding from GSK for investigator-driven research outside the scope of this work. Professor Stone's hospital, the Massachusetts General Hospital, owns the intellectual property of the pGTI. The worldwide licensing rights to the pGTI are controlled by Steritas, LLC. Professor Stone co-founded Steritas and is the chair of the Scientific Advisory Board but has no fiduciary responsibility at the company. The remaining co-authors have no other relevant financial conflicts of interest to disclose., (Copyright © 2024. Published by Elsevier Inc.)
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- 2024
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29. Corrigendum to "The Glucocorticoid Toxicity Index: Measuring Change in Glucocorticoid Toxicity Over Time" [Seminars in Arthritis and Rheumatism 55 (2022):152010].
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Stone JH, McDowell PJ, Jayne DRW, Merkel PA, Robson J, Patel NJ, Zhang Y, Yue H, Bekker P, and Heaney LG
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- 2024
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30. Scleroderma Renal Crisis: Clues From the Physical Exam.
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Patel AV, Tinianow AM, Petrasko PV, and Stone JH
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Scleroderma renal crisis (SRC) is a rare, life-threatening complication of systemic sclerosis (SSc) and can sometimes be the first manifestation of the disease.
1 A 56-year-old female presented with acute encephalopathy requiring intubation and a systolic blood pressure of 230 mmHg; no information was available about her medical history.- Published
- 2024
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31. Developing an Injury-Free 15 Hour Preservation Protocol of Donor Porcine Kidneys Using Normothermic Machine Perfusion.
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Stone JP, Cowey WR, Bowers CJT, Stewart AF, Armstrong ER, Clancy M, Entwistle TR, Del Pozo J, Amin K, and Fildes JE
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Normothermic machine perfusion (NMP) offers a superior alternative to hypothermic preservation but is currently time limited. Extending this time could electivise transplantation and enable physiologic assessments of functionality. Porcine kidneys were retrieved, stored on ice for 3.5 hours before being placed onto a NMP circuit for 12 hours. Hemodynamics, biochemistry, and urine output were assessed. After 12 hours, kidneys were scored using the clinical assessment score. Biopsies were collected for histological assessment. Kidneys demonstrated continual improvements in hemodynamics. Perfusate sodium concentrations remained within physiologic parameters. Sodium bicarbonate increased over-time with corresponding decreases in lactate, demonstrating active renal gluconeogenesis and Cori cycle processes. Urine production began immediately and was sustained, indicating renal functionality. Under the clinical perfusion assessment score, all kidneys received a score of 1 and would be considered suitable for transplantation. Histological assessment revealed kidneys were injury free. Our NMP protocol safely preserves kidneys for over 15 hours. Successful perfusion was achieved with stable hemodynamics and biochemistry, with maintained urination. Importantly, kidneys remained in optimal health, with no evidence of injury. This may enable electivisation of transplantation, while reducing hypothermic injury., Competing Interests: Disclosure: J.E.F. is a founding director and majority shareholder of Pebble Biotechnology Laboratories Limited (PBL) and J.P.S., T.R.E., and other employees of PBL have an interest in the equity of that company. PBL has developed much of the technology and protocol that is the focus of this study and has also provided additional funding and support for the research conducted, and has an intent to commercialize technology where it is viable, of value and can enhance the care of kidney patients. J.E.F., J.P.S., and T.R.E. are also directors of the Ex-Vivo Research Centre CIC, which received shares in PBL in consideration for access to IP, know-how and commercialization rights, and so consequently stands to benefit from any commercialization of the technology. The EVRC aims are to research, educate, and disseminate best practice in kidney care. The other authors have no conflicts of interest to report., (Copyright © ASAIO 2024.)
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- 2024
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32. The clinical outcomes and healthcare resource utilization in IgG4-related disease: a claims-based analysis of commercially insured adults in the United States.
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Wallace ZS, Miles G, Smolkina E, Petruski-Ivleva N, Madziva D, Guzzo K, Cook C, Fu X, Zhang Y, Stone JH, and Choi HK
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Objectives: IgG4-related disease (IgG4-RD) can affect nearly any organ and is often treated with glucocorticoids, which contribute to organ damage and toxicity. Comorbidities and healthcare utilization in IgG4-RD are poorly understood., Methods: We conducted a cohort study using claims data from a United States managed care organization. Incident IgG4-RD cases were identified using a validated algorithm; general population comparators were matched by age, sex, race/ethnicity, and index date. The frequency of 21 expert-defined clinical outcomes associated with IgG4-RD or its treatment and healthcare-associated visits and costs were assessed 12 months before and 36 months after the index date (date of earliest IgG4-RD-related claim)., Results: There were 524 cases and 5,240 comparators. Most cases received glucocorticoids prior to (64.0%) and after (85.1%) the index date. Nearly all outcomes, many being common glucocorticoid toxicities, occurred more frequently in cases vs comparators. During follow-up, the largest differences between cases and comparators were seen for gastroesophageal reflux disease (prevalence difference: +31.2%, p< 0.001); infections (+17.3%, p< 0.001); hypertension (+15.5%, p< 0.01); and diabetes mellitus (+15.0%, p< 0.001). The difference in malignancy increased during follow-up from +8.8% to + 12.5% (p< 0.001). 17.4% of cases used pancreatic enzyme replacement therapy during follow-up. Over follow-up, cases were more often hospitalized (57.3% vs 17.2%, p< 0.01) and/or had an ER visit (72.0% vs 36.7%, p< 0.01); all costs were greater in cases than comparators., Conclusions: Patients with IgG4-RD are disproportionately affected by adverse outcomes, some of which may be preventable or modifiable with vigilant clinician monitoring. Glucocorticoid-sparing treatments may improve these outcomes., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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- 2024
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33. Multimodality Imaging Features of Immunoglobulin G4-related Vessel Involvement.
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O'Shea A, Crotty RK, Randhawa MK, Oliveira G, Perugino CA, Stone JH, Harisinghani MG, Wallace ZS, and Hedgire SS
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- Humans, Immunoglobulin G, Multimodal Imaging, Aorta, Inflammation, Immunoglobulin G4-Related Disease diagnostic imaging
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Immunoglobulin 4 (IgG4)-related disease is a chronic immune-mediated fibroinflammatory disorder. Involvement of the vascular system, including large- and medium-sized vessels, is increasingly recognized. The varied appearances of vascular involvement reflect the sequela of chronic inflammation and fibrosis and can include aortitis and periaortitis with resultant complications such as aneurysm formation and dissection. A diagnosis of IgG4-related large vessel involvement should be considered when there is known or suspected IgG4-related disease elsewhere. Other organs that are typically affected in IgG4-related disease include the lacrimal and salivary glands, thyroid, pancreas, biliary tree, lungs, kidneys, and meninges. Diagnosis typically requires careful correlation with clinical, imaging, serum, and pathologic findings. Patients may be managed with corticosteroid therapy or the anti-CD20 monoclonal antibody, rituximab, if needed. The varied clinical presentations and imaging features of large vessel involvement are discussed herein. Keywords: Vascular, Inflammation, Aorta, IgG4-related Vessel Involvement © RSNA, 2024.
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- 2024
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