8 results on '"Stratton, Michael R"'
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2. Geographic variation of mutagenic exposures in kidney cancer genomes
- Author
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Senkin, Sergey, Moody, Sarah, Díaz-Gay, Marcos, Abedi-Ardekani, Behnoush, Cattiaux, Thomas, Ferreiro-Iglesias, Aida, Wang, Jingwei, Fitzgerald, Stephen, Kazachkova, Mariya, Vangara, Raviteja, Le, Anh Phuong, Bergstrom, Erik N., Khandekar, Azhar, Otlu, Burçak, Cheema, Saamin, Latimer, Calli, Thomas, Emily, Atkins, Joshua Ronald, Smith-Byrne, Karl, Cortez Cardoso Penha, Ricardo, Carreira, Christine, Chopard, Priscilia, Gaborieau, Valérie, Keski-Rahkonen, Pekka, Jones, David, Teague, Jon W., Ferlicot, Sophie, Asgari, Mojgan, Sangkhathat, Surasak, Attawettayanon, Worapat, Świątkowska, Beata, Jarmalaite, Sonata, Sabaliauskaite, Rasa, Shibata, Tatsuhiro, Fukagawa, Akihiko, Mates, Dana, Jinga, Viorel, Rascu, Stefan, Mijuskovic, Mirjana, Savic, Slavisa, Milosavljevic, Sasa, Bartlett, John M. S., Albert, Monique, Phouthavongsy, Larry, Ashton-Prolla, Patricia, Botton, Mariana R., Silva Neto, Brasil, Bezerra, Stephania Martins, Curado, Maria Paula, Zequi, Stênio de Cássio, Reis, Rui Manuel, Faria, Eliney Ferreira, de Menezes, Nei Soares, Ferrari, Renata Spagnoli, Banks, Rosamonde E., Vasudev, Naveen S., Zaridze, David, Mukeriya, Anush, Shangina, Oxana, Matveev, Vsevolod, Foretova, Lenka, Navratilova, Marie, Holcatova, Ivana, Hornakova, Anna, Janout, Vladimir, Purdue, Mark P., Rothman, Nathaniel, Chanock, Stephen J., Ueland, Per Magne, Johansson, Mattias, McKay, James, Scelo, Ghislaine, Chanudet, Estelle, Humphreys, Laura, de Carvalho, Ana Carolina, Perdomo, Sandra, Alexandrov, Ludmil B., Stratton, Michael R., and Brennan, Paul
- Published
- 2024
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3. The Mutographs biorepository: A unique genomic resource to study cancer around the world
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Perdomo, Sandra, Abedi-Ardekani, Behnoush, de Carvalho, Ana Carolina, Ferreiro-Iglesias, Aida, Gaborieau, Valérie, Cattiaux, Thomas, Renard, Hélène, Chopard, Priscilia, Carreira, Christine, Spanu, Andreea, Nikmanesh, Arash, Cardoso Penha, Ricardo Cortez, Antwi, Samuel O., Ashton-Prolla, Patricia, Canova, Cristina, Chitapanarux, Taned, Cox, Riley, Curado, Maria Paula, de Oliveira, José Carlos, Dzamalala, Charles, Fabianova, Elenora, Ferri, Lorenzo, Fitzgerald, Rebecca, Foretova, Lenka, Gallinger, Steven, Goldstein, Alisa M., Holcatova, Ivana, Huertas, Antonio, Janout, Vladimir, Jarmalaite, Sonata, Kaneva, Radka, Kowalski, Luiz Paulo, Kulis, Tomislav, Lagiou, Pagona, Lissowska, Jolanta, Malekzadeh, Reza, Mates, Dana, McCorrmack, Valerie, Menya, Diana, Mhatre, Sharayu, Mmbaga, Blandina Theophil, de Moricz, André, Nyirády, Péter, Ognjanovic, Miodrag, Papadopoulou, Kyriaki, Polesel, Jerry, Purdue, Mark P., Rascu, Stefan, Rebolho Batista, Lidia Maria, Reis, Rui Manuel, Ribeiro Pinto, Luis Felipe, Rodríguez-Urrego, Paula A., Sangkhathat, Surasak, Sangrajrang, Suleeporn, Shibata, Tatsuhiro, Stakhovsky, Eduard, Świątkowska, Beata, Vaccaro, Carlos, Vasconcelos de Podesta, Jose Roberto, Vasudev, Naveen S., Vilensky, Marta, Yeung, Jonathan, Zaridze, David, Zendehdel, Kazem, Scelo, Ghislaine, Chanudet, Estelle, Wang, Jingwei, Fitzgerald, Stephen, Latimer, Calli, Moody, Sarah, Humphreys, Laura, Alexandrov, Ludmil B., Stratton, Michael R., and Brennan, Paul
- Published
- 2024
- Full Text
- View/download PDF
4. Procarbazine-induced Genomic Toxicity in Hodgkin Lymphoma Survivors
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Santarsieri, Anna, primary, Mitchell, Emily, additional, Pham, My H., additional, Sanghvi, Rashesh, additional, Jablonski, Janina, additional, Lee-Six, Henry, additional, Sturgess, Katherine, additional, Brice, Pauline, additional, Menne, Tobias F., additional, Osborne, Wendy, additional, Creasey, Thomas, additional, Ardeshna, Kirit M., additional, Baxter, Joanna, additional, Behan, Sarah, additional, Bhuller, Kaljit, additional, Booth, Stephen, additional, Chavda, Nikesh D., additional, Collins, Graham P., additional, Culligan, Dominic J., additional, Cwynarski, Kate, additional, Davies, Andrew, additional, Downing, Abigail, additional, Dutton, David, additional, Furtado, Michelle, additional, Gallop-Evans, Eve, additional, Hodson, Andrew, additional, Hopkins, David, additional, Hsu, Hannah, additional, Iyengar, Sunil, additional, Jones, Stephen G., additional, Karanth, Mamatha, additional, Linton, Kim M., additional, Lomas, Oliver C., additional, Martinez-Calle, Nicolas, additional, Mathur, Abhinav, additional, McKay, Pamela, additional, Nagumantry, Sateesh K., additional, Phillips, Elizabeth H., additional, Phillips, Neil, additional, Rudge, John F., additional, Shah, Nimish K., additional, Stafford, Gwyneth, additional, Sternberg, Alex, additional, Trickey, Rachel, additional, Uttenthal, Benjamin J., additional, Wetherall, Natasha, additional, Zhang, Xiao-Yin, additional, McMillan, Andrew K., additional, Coleman, Nicholas, additional, Stratton, Michael R., additional, Laurenti, Elisa, additional, Borchmann, Peter, additional, Borchmann, Sven, additional, Campbell, Peter J., additional, Rahbari, Raheleh, additional, and Follows, George A., additional
- Published
- 2024
- Full Text
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5. The long-term effects of chemotherapy on normal blood cells
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Mitchell, Emily, primary, Pham, My H., additional, Clay, Anna, additional, Sanghvi, Rashesh, additional, Pietsch, Sandra, additional, Hsu, Joanne I., additional, Jung, Hyunchul, additional, Vedi, Aditi, additional, Moody, Sarah, additional, Wang, Jingwei, additional, Leonganmornlert, Daniel, additional, Chapman, Michael Spencer, additional, Williams, Nicholas, additional, Dunstone, Ellie, additional, Santarsieri, Anna, additional, Cagan, Alex, additional, Machado, Heather E., additional, Baxter, Joanna, additional, Follows, George, additional, Hodson, Daniel J, additional, McDermott, Ultan, additional, Doherty, Gary J., additional, Martincorena, Inigo, additional, Humphreys, Laura, additional, Mahbubani, Krishnaa, additional, Parsy, Kourosh Saeb, additional, Takahashi, Koichi, additional, Goodell, Margaret A., additional, Kent, David, additional, Laurenti, Elisa, additional, Campbell, Peter J., additional, Rahbari, Raheleh, additional, Nangalia, Jyoti, additional, and Stratton, Michael R., additional
- Published
- 2024
- Full Text
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6. The Complexity of Tobacco Smoke-Induced Mutagenesis in Head and Neck Cancer
- Author
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Torrens, Laura, primary, Moody, Sarah, additional, de Carvalho, Ana Carolina, additional, Kazachkova, Mariya, additional, Abedi-Ardekani, Behnoush, additional, Cheema, Saamin, additional, Senkin, Sergey, additional, Cattiaux, Thomas, additional, Cortez Cardoso Penha, Ricardo, additional, Atkins, Joshua R, additional, Gaborieau, Valérie, additional, Chopard, Priscilia, additional, Carreira, Christine, additional, Abbasi, Ammal, additional, Bergstrom, Erik N, additional, Vangara, Raviteja, additional, Wang, Jingwei, additional, Fitzgerald, Stephen, additional, Latimer, Calli, additional, Diaz-Gay, Marcos, additional, Jones, David, additional, Teague, Jon, additional, Ribeiro Pinto, Felipe, additional, Kowalski, Luiz Paulo, additional, Polesel, Jerry, additional, Giudici, Fabiola, additional, de Oliveira, José Carlos, additional, Lagiou, Pagona, additional, Lagiou, Areti, additional, Vilensky, Marta, additional, Mates, Dana, additional, Mates, Ioan N, additional, Arantes, Lidia MRB, additional, Reis, Rui, additional, Podesta, Jose Roberto V, additional, von Zeidler, Sandra V, additional, Holcatova, Ivana, additional, Curado, Maria Paula, additional, Canova, Cristina, additional, Fabianova, Elenora, additional, Rodríguez-Urrego, Paula A, additional, Humphreys, Laura, additional, Alexandrov, Ludmil B, additional, Brennan, Paul, additional, Stratton, Michael R, additional, and Perdomo, Sandra, additional
- Published
- 2024
- Full Text
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7. WCN24-1870 CHRONIC RENAL LESIONS IN PATIENTS WITH RENAL CELL CARCINOMA ARE ASSOCIATED WITH ARISTOLOCHIC ACID EXPOSURE AND FASTER ACCUMULATION OF DNA DAMAGE
- Author
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ABEDI-ARDEKANI, Behnoush, primary, Martin, Fannie, additional, Senkin, Sergey, additional, Moody, Sarah, additional, Cattiaux, Thomas, additional, Wang, Yichen, additional, Ferreiro-Iglesias, Aida, additional, Gaborieau, Valerie, additional, Perdomo, Sandra, additional, Humphreys, Laura, additional, Stratton, Michael R., additional, Brennan, Paul, additional, Foll, Matthieu, additional, and Alcala, Nicolas, additional
- Published
- 2024
- Full Text
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8. The Complexity of Tobacco Smoke-Induced Mutagenesis in Head and Neck Cancer.
- Author
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Torrens L, Moody S, de Carvalho AC, Kazachkova M, Abedi-Ardekani B, Cheema S, Senkin S, Cattiaux T, Cortez Cardoso Penha R, Atkins JR, Gaborieau V, Chopard P, Carreira C, Abbasi A, Bergstrom EN, Vangara R, Wang J, Fitzgerald S, Latimer C, Diaz-Gay M, Jones D, Teague J, Ribeiro Pinto F, Kowalski LP, Polesel J, Giudici F, de Oliveira JC, Lagiou P, Lagiou A, Vilensky M, Mates D, Mates IN, Arantes LM, Reis R, Podesta JRV, von Zeidler SV, Holcatova I, Curado MP, Canova C, Fabianova E, Rodríguez-Urrego PA, Humphreys L, Alexandrov LB, Brennan P, Stratton MR, and Perdomo S
- Abstract
Tobacco smoke, alone or combined with alcohol, is the predominant cause of head and neck cancer (HNC). Here, we further explore how tobacco exposure contributes to cancer development by mutational signature analysis of 265 whole-genome sequenced HNC from eight countries. Six tobacco-associated mutational signatures were detected, including some not previously reported. Differences in HNC incidence between countries corresponded with differences in mutation burdens of tobacco-associated signatures, consistent with the dominant role of tobacco in HNC causation. Differences were found in the burden of tobacco-associated signatures between anatomical subsites, suggesting that tissue-specific factors modulate mutagenesis. We identified an association between tobacco smoking and three additional alcohol-related signatures indicating synergism between the two exposures. Tobacco smoking was associated with differences in the mutational spectra and repertoire of driver mutations in cancer genes, and in patterns of copy number change. Together, the results demonstrate the multiple pathways by which tobacco smoke can influence the evolution of cancer cell clones.
- Published
- 2024
- Full Text
- View/download PDF
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