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The Komodo dragon is a unique reptile with an elongated tail that exhibits hitherto unknown adaptations and functions. This tail, composed of 60–86 vertebrae, serves diverse ecological and physiological roles. In juveniles, it is essential for an arboreal lifestyle and balance, while in adults, it functions as a tool for defense and offensive actions. It possesses characteristic haemal arches and a dorsal keel, along with well-developed muscles which enable precise tail control, influencing the Komodo dragon’s maneuverability and directional changes. The tail stores adipose tissue, providing Komodo dragons with the ability to regulate body temperature and independence from other seasonal variations. The tail adipose tissue impacts numerous biochemical processes and may play a crucial role in the animals’ metabolic strategies and reproductive capabilities. Its functions include providing essential mineral compounds for the organism, such as calcium, phosphorus, magnesium, iron, and zinc. Analysing the biochemical composition of tail fat is crucial for understanding the health of Komodo dragons.

The leaves of Ilex paraguariensis (known as Yerba mate), used as a popular beverage, are a very well-recognized plant material with various biological activities, including analeptic (because of caffeine), anti-obesity (phenolics, saponins), antimicrobial, and antiviral (phenolics, saponins). Here, the chemical compositions of the leaves of two European Ilex species (× meserveae and aquifolium) with three varieties each were investigated. The terpenoid, saponin, and polyphenolic fractions were submitted for LC-MS or GC-MS analysis against a standard Mate leaf. In addition, the aroma profiles of all the species were analysed using HS-SPME-Arrow prior to GC-MS analysis. All fractions were subjected to antiviral and cytotoxic assays. We found 86 compounds in all accessions, with limonene, linalool, and p-cymene being predominant. There were minor similarities between the volatile compositions of the European and South American species. We found ursolic and oleanolic acid to be the main compounds in the terpenoid fraction. Mono-caffeoylquinic acids and di-caffeoylquinic acids were the main constituents of the polar fractions. About 180 compounds from the saponin group were tentatively identified, of which 9 and 3 were selected as distinctive markers for I. meserveae and I. aquifolium, respectively. Based on chemical screening, I. aquifolium Silver Queen was chosen as the source of terpenoid and saponin fractions and polyphenol extracts. The most substantial inhibition of cancer cell growth was observed with saponin in the case of the MCF7 (human breast cancer) cell line, while for LoVo and L929 cell lines (human colorectal cancer and reference mouse fibroblasts), it was slightly weaker. These results should be analysed further as a promising chemoprevention of colorectal and gastrointestinal cancers. Saponin and polyphenolic extracts exhibited similar activities against HSV-1 and HAdV-5, with 4-log reduction in virus titres. This study focuses our attention on a field of potential antiviral formulations derived from European holly.