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Introduction and Hypothesis: The objective was to compare the vaginal and laparoscopic approaches with natural tissue vaginal repair of pelvic organ prolapse (POP) in terms of recurrence rate and complete remission rate (CRR) of symptoms., Materials and Methods: This retrospective cohort study analyzed women who underwent hysterectomy for uterine prolapse at two Italian hospitals between October 2021 and March 2023. Group A included 89 patients who received vaginal hysterectomy and colposuspension (VCH), whereas group B included 58 patients who underwent laparoscopic hysterectomy followed by laparoscopic colposuspension sec Shull (LPSS)., Results: The study included 147 patients with comparable baseline characteristics regarding menopausal age and body mass index. Concerning preoperative data, it is worth mentioning that group A had a higher proportion of patients with more than two previous deliveries and, overall, more severe prolapse stages. Concerning postoperative results, the patients undergoing laparoscopic surgery had longer operation times than group A. Moreover, group B had a higher recurrence rate after surgery (5.6% vs 13%, p = 0.057). Kaplan-Meier analysis indicated a lower rate of prolapse-free patients over time in group B. Cox regression showed a higher hazard ratio for recurrence in the LCSS group than in the VCH group. Complete remission rates for urinary symptoms varied, with group B showing higher CRR for stress incontinence (33% vs 71%, p < 0.001)., Conclusion: Both VCH and LCSS are effective for POP treatment, with VCH showing better outcomes in terms of symptom remission and shorter operation times. At the same time, LCSS had better CRR for stress incontinence but a higher recurrence rate. Further high-quality prospective studies are needed to confirm these findings and determine the best surgical approach for POP., Competing Interests: Declarations. Ethical or Institutional Review Board Approval: The study was conducted in two university clinics where all patients treated must sign a dedicated consent for anonymous data processing. According to the regulations in force in the state where the study was conducted, no institutional review board approval is required owing to the retrospective nature of the study.  Declaration of Generative AI in Scientific Writing: The authors declare that no AI was used to write the original draft. Grammar correction tools (Grammarly, Inc) were used to improve the quality of English and readability. The technology was used under human oversight and control. The present article has not been submitted to any other journal. Submission Declaration: The present article has not been submitted to any other Journal. Conflicts of Interest: The authors declare that there are no conflicts of interest., (© 2024. The International Urogynecological Association.)

Aims: The use of mechanical valve prostheses in cardiac surgery remains a necessary and indicated intervention in a large number of patients. However, predicted results associated with their use, on which current guideline recommendations have been developed, are based on dated studies at risk of bias (e.g. use of old generation models, very high international normalized ratio regimes)., Methods: A comprehensive search in multiple electronic databases was conducted from January 1995 to January 2024 using predefined criteria. The primary outcomes included all-cause death, bleeding events and thromboembolic events (i.e. stroke) at follow-up., Results: Overall, 38 studies were included in the meta-analysis. Cumulative meta-analysis results for mortality, thromboembolic events and bleeding events were initially extremely variable and tended to become more consistent over time. A meta-regression for the impact of age and sex on mortality showed no difference, whereas a meta-regression for the impact of age and sex on thromboembolic events and on bleeding events showed a higher risk in the elderly and in female patients, respectively., Conclusion: The lack of fundamental information on the type of anticoagulant treatment (e.g. dosage, monitoring method) in the studies published to date does not allow us to draw any definitive conclusions on the outcomes of mechanical valve prostheses. The most recent studies have provided more consistent results, which in the past were highly variable, probably due to overcoming the bias in the use of prosthetic models of different generations., (Copyright © 2024 Italian Federation of Cardiology - I.F.C. All rights reserved.)

Introduction and Hypothesis: Obstetric anal sphincter injuries (OASIs), third- and fourth-degree lacerations, represent a severe obstetric complication. Previous studies reported a higher incidence of OASIs in Asian women in non-Asian countries. This study was aimed at establishing a different OASIs prevalence among the racial/ethnic groups in Southern European centers., Methods: A multicenter retrospective study that included pregnant women who had vaginal singleton delivery between January 2019 and September 2022 in two Italian University hospitals, Naples and Novara, was conducted. We excluded cesarean sections, nonvertex presentation, preterm delivery, multiple pregnancies, congenital malformations, or stillbirths. Statistical analysis with an independent association of ethnicity to the risk of OASIs using clinical characteristics-adjusted multivariate logistic regression was performed., Results: A total of 3,049 pregnant women were included. 2.33% (71 patients) had an OASI. The median age was 31 years (IQR 7.00) and median gestational age was 39 weeks (IQR 1.40). Mean birth weight was 3,300 g (IQR 580.00). 1' and 5' Apgar scores were 9 and 9. The univariate logistic regression was not statistically significant. Multivariate logistic regression model adjusted for baseline clinical characteristics showed an OR 2.540 (p value 0.01) for OASIs in Asian women. Primiparous and secondiparous were protective factors for OASIs with OR 0.224 (p value < 0.001) and OR 0.209 (p value 0.01)., Conclusions: Our results confirm racial/ethnic disparities regarding OASIs, with an elevated risk for Asian women in Southern Europe. Prevention strategies and obstetric care in developed countries should be modulated to offset the risk of OASIs in this population. Additional research is needed to explain the specific mechanisms of these disparities., Competing Interests: Declarations. Ethics Approval: Ethics approval (protocol number 0011344/I of 17 April 2024) was obtained from the Ethics Committee of Campania 2, Naples, Italy. Consent to Participate: Written informed consent was obtained from all individual participants included in the study. Conflicts of Interest: None., (© 2024. The International Urogynecological Association.)