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A study conducted at Khyber Teaching Hospital compared the efficacy of sublingual versus vaginal misoprostol for treating first-trimester missed miscarriages. The research found that the sublingual approach had a higher success rate and was associated with fewer adverse effects compared to the vaginal method. Patients reported feeling more comfortable with the sublingual administration, indicating a preference for this method. The study concluded that sublingual misoprostol was more effective and better tolerated by patients. [Extracted from the article]