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The Permian Basin is one of the most prolific, and currently one of the most active, oil and gas basins in the USA. The Lower Permian strata in the Permian Basin have produced more than 14 billion barrels of oil (BBO), making it the largest volume of hydrocarbon in the basin. Sedimentation in the Midland Basin during late Leonardian through early Guadalupian (ca. 272e269 Ma) resulted in progradation of shelf edge and ultimately closure of the basin by Middle Permian time. We analyzed a merged seismic survey covering parts of the Permian Basin (i.e., Central Basin Platform and Midland Basin) in Andrews, Ector, and Midland Counties, Texas. The seismic survey and well logs show the presence of gently dipping (ca. 1°) clinoforms in the Upper San Andres and Grayburg Formations on the eastern edge of the Central Basin Platform and western Midland Basin. The seismic attributes, curvature, and spectral decomposition identify low sinuosity slope channels oriented north-south, but such channels do not appear beyond the slope. The shelf edge shifts from north to south during deposition of the Upper San Andres and Grayburg Formations. We identify five basinward shifts noted by the migration of the shelf edge toward the basin center and the presence of channel features along the depositional slope. The petrophysical analysis indicates that channels cut into carbonate rocks and are filled by siliciclastic sediments; this interpretation is supported by the most negative curvature anomalies along the channel axes caused by the differential compaction between the carbonate and siliciclastic rocks. There are a few channels with a northwest-southeast strike, which matches the direction of the Concho Lineament observed by satellite data. Such observations are consistent with previous interpretations of the northern Midland Basin closure during Middle-Late Permian time. [ABSTRACT FROM AUTHOR]

Cytoplasmic and nuclear iron-sulfur (Fe-S) enzymes that are essential for genome maintenance and replication depend on the cytoplasmic Fe-S assembly (CIA) machinery for cluster acquisition. The core of the CIA machinery consists of a complex of CIAO1, MMS19 and FAM96B. The physiological consequences of loss of function in the components of the CIA pathway have thus far remained uncharacterized. Our study revealed that patients with biallelic loss of function in CIAO1 developed proximal and axial muscle weakness, fluctuating creatine kinase elevation, and respiratory insufficiency. In addition, they presented with CNS symptoms including learning difficulties and neurobehavioral comorbidities, along with iron deposition in deep brain nuclei, mild normocytic to macrocytic anemia, and gastrointestinal symptoms. Mutational analysis revealed reduced stability of the variants compared with WT CIAO1. Functional assays demonstrated failure of the variants identified in patients to recruit Fe-S recipient proteins, resulting in compromised activities of DNA helicases, polymerases, and repair enzymes that rely on the CIA complex to acquire their Fe-S cofactors. Lentivirus-mediated restoration of CIAO1 expression reversed all patient-derived cellular abnormalities. Our study identifies CIAO1 as a human disease gene and provides insights into the broader implications of the cytosolic Fe-S assembly pathway in human health and disease. [ABSTRACT FROM AUTHOR]

Introduction Methods Results Conclusions Left bundle branch area (LBBA) pacing (LBBAP) has been proposed as an alternative therapy option in patients indicated for cardiac pacing to treat bradycardia or heart failure. The aim of the study was to evaluate the safety and effectiveness of LBBAP in patients implanted with a Tendril 2088 stylet‐driven lead.The international retrospective data collection registry included 11 sites from 5 countries globally. Patients with attempted implants of the Tendril lead in the LBBA were followed for at least 6 months post the implant attempt. The primary safety and efficacy endpoints were freedom from LBBAP lead‐related serious adverse events and the composite of LBBA capture threshold of ≤2.0 V and R‐wave amplitudes ≥5 mV (or ≥value at implant), respectively.Of 221 patients with attempted implants of the Tendril 2088 lead in the LBBA, 91.4% (202/221) had successful implants for LBBAP. Regardless of the LBBAP implant success, all patients were followed for at least 6 months (8.7 ± 7.3 months). Baseline characteristics: 44% female, 84% ≥65 years old, 34% coronary artery disease, and 86% of primary indications for pacemaker implant. Both primary safety and effectiveness endpoints were met (freedom from LBBAP lead‐related serious adverse device effects of 99.5% and electrical performance composite success rate of 93%). The capture thresholds in LBBAP at implant and 6 months were 0.8 ± 0.3 V@0.4 ± 0.1 ms and 0.8 ± 0.3 V@0.4 ± 0.1 ms. The rate of patients with capture threshold rise ≥1 V was 1.5% through 6 months. The R‐wave amplitudes in LBBAP at implant and 6 months were 9.3 ± 3.2 mV and 10.6 ± 3.0 mV.This large multicenter study demonstrates that the stylet‐driven Tendril™ STS 2088 lead is safe and effective for LBBAP with high success and low complication rates. [ABSTRACT FROM AUTHOR]

Introduction/Aims: Objective outcome measures in children undergoing treatment for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are lacking. The aim of the study was to record serial grip strength and motor nerve conduction studies to assess interval change. Methods: This was a retrospective review of 16 children (8 females and 8 males; median age, 9.7 years; interquartile range, 6–13 years) with CIDP followed at a tertiary children's hospital from 2013 to 2021. Subjects were treated with intravenous immunoglobulin (IVIG). Right and left grip strength measurements were obtained at each clinic visit using a handheld dynamometer. Annual right median motor nerve conduction study data were recorded during the study period. Results: Mean duration of follow‐up was 2.9 years. Grip strength (right: 0.19 kg/month, p < 0.001; left 0.23 kg/month, p < 0.001) and median F‐wave latencies (−0.23/month, p = 0.015) showed significant improvement over time. Akaike information criterion showed time + IVIG frequency <21 days as best fit for grip strength and distal compound muscle action potential amplitude. Discussion: Our study results indicate serial grip strength measurements are a feasible and objective way to assess motor strength improvement in children with CIDP receiving immunotherapy. [ABSTRACT FROM AUTHOR]

The Pennsylvanian unconformity, which is a detrital surface, separates the beds of the Permian-aged strata from the Lower Paleozoic in the Central Basin Platform. Seismic data interpretation indicates that the unconformity is an angular unconformity, overlying multiple normal faults, and accompanied with a thrust fault which maximizes the region's structural complexity. Additionally, the Pennsylvanian angular unconformity creates pinch-outs between the beds above and below. We computed the spectral decomposition and reflector convergence attributes and analyzed them to characterize the angular unconformity and faults. The spectral decomposition attribute divides the broadband seismic data into different spectral bands to resolve thin beds and show thickness variations. In contrast, the reflector convergence attribute highlights the location and direction of the pinch-outs as they dip south at angles between 2° and 6°. After reviewing findings from RGB blending of the spectrally decomposed frequencies along the Pennsylvanian unconformity, we observed channel-like features and multiple linear bands in addition to the faults and pinch-outs. It can be inferred that the identified linear bands could be the result of different lithologies associated with the tilting of the beds, and the faults may possibly influence hydrocarbon migration or act as a flow barrier to entrap hydrocarbon accumulation. The identification of this angular unconformity and the associated features in the study area are vital for the following reasons: 1) the unconformity surface represents a natural stratigraphic boundary; 2) the stratigraphic pinch-outs act as fluid flow connectivity boundaries; 3) the areal extent of compartmentalized reservoirs' boundaries created by the angular unconformity are better defined; and 4) fault displacements are better understood when planning well locations as faults can be flow barriers, or permeability conduits, depending on facies heterogeneity and/or seal effectiveness of a fault, which can affect hydrocarbon production. The methodology utilized in this study is a further step in the characterization of reservoirs and can be used to expand our knowledge and obtain more information about the Goldsmith Field. [ABSTRACT FROM AUTHOR]

Shark is a seafood commodity that is a good source of minerals and accumulates heavy metals and trace elements through biomagnification, which can pose health risk if taken above the permissible limit. A study was conducted on commonly landed eleven shark species (Scoliodon laticaudus , Rhizopriodon oligolinx , Sphyrna lewini (CR), Carcharhinus macloti , Carcharinus limbatus , Carcharhinus amblyrhynchoides , Carcharhinus sorrah, Carcharinus falciformes(VU), Glaucostegus granulatus, Chiloscyllium arabicum, Loxodon macrorhinus) and analyzed for their heavy metal content, Hazard Index, Total Hazard Quotient, Metal Pollution Index, and also calculated the health risk associated with the consumption. Most of the heavy metals and trace minerals were found to be within the acceptable limit. The Targeted Hazard Quotient (THQ) and the Hazard Index (HI) of all the species except two were less than 1 (HI ≤ 1.0). The Metal Pollution Index (MPI) is showing either no impact or very low contamination. An overall study on hazard identification and health risk characterization in terms of heavy metals shows contamination of some heavy metals in sharks, but there is no potential human health risk associated with consumption. • Total eleven shark species are evaluated for non-carcinogenic health risk due to selected heavy metals. • THQ, HI and Metal Pollution Index are within the safer limits. • Heavy metal content in the commonly landed shark species, along the Saurashtra coast of India is safe to consume. [ABSTRACT FROM AUTHOR]