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Remote sensing indices are widely used in various fields of geoscience research. However, there are limits to how effectively the knowledge of indices can be managed or analyzed. One of the main problems is the lack of ontology models and research on indices, which makes it difficult to acquire and update knowledge in this area. Additionally, there is a lack of techniques to analyze the mathematical semantics of indices, making it difficult to directly manage and analyze their mathematical semantics. This study utilizes an ontology and mathematical semantics integration method to offer a novel knowledge graph for a remote sensing index knowledge graph (RSIKG) so as to address these issues. The proposed semantic hierarchical graph structure represents the indices of knowledge with an entity-relationship layer and a mathematical semantic layer. Specifically, ontologies in the entity-relationship layer are constructed to model concepts and relationships among indices. In the mathematical semantics layer, index formulas are represented using mathematical semantic graphs. A method for calculating similarity for index formulas is also proposed. The article describes the entire process of building RSIKG, including the extraction, storage, analysis, and inference of remote sensing index knowledge. Experiments provided in this article demonstrate the intuitive and practical nature of RSIKG for analyzing indices knowledge. Overall, the proposed methods can be useful for knowledge queries and the analysis of indices. And the present study lays the groundwork for future research on analysis techniques and knowledge processing related to remote sensing indices. [ABSTRACT FROM AUTHOR]

High-precision and safety control in face of disturbances and uncertainties is a challenging issue of both theoretical and practical importance. In this article, new adaptive anti-disturbance control schemes are proposed for a class of uncertain nonlinear systems with composite disturbances, including additive disturbances, multiplicative actuator faults, and implicit disturbances deeply coupled with system states. Both the cases with known and unknown control/fault directions are investigated. By properly fusing the techniques of disturbance observers and adaptive compensation, it is shown that all closed-loop signals are globally uniformly bounded and the tracking error converges to zero asymptotically, no matter the control/fault directions are known or not. In the case of known directions, the proposed control scheme, for the first time, guarantees asymptotic tracking and L ∞ tracking performance simultaneously in face of disturbances and actuator faults. Moreover, novel Nussbaum functions and a contradiction argument are introduced, which allow the system to have multiple unknown nonidentical control directions and unknown time-varying fault direction. Simulation results illustrate the effectiveness of the proposed control schemes.

Background and Aims: Epigenetic reprogramming and escape from terminal differentiation are poorly understood enabling characteristics of liver cancer. Keratin 19 (KRT19), classically known to form the intermediate filament cytoskeleton, is a marker of stemness and worse prognosis in liver cancer. This study aimed to address the functional roles of KRT19 in liver tumorigenesis and to elucidate the underlying mechanisms., Approach and Results: Using multiplexed genome editing of hepatocytes in vivo, we demonstrated that KRT19 promoted liver tumorigenesis in mice. Cell fractionation revealed a previously unrecognized nuclear fraction of KRT19. Tandem affinity purification identified histone deacetylase 1 and REST corepressor 1, components of the corepressor of RE-1 silencing transcription factor (CoREST) complex as KRT19-interacting proteins. KRT19 knockout markedly enhanced histone acetylation levels. Mechanistically, KRT19 promotes CoREST complex formation by enhancing histone deacetylase 1 and REST corepressor 1 interaction, thus increasing the deacetylase activity. ChIP-seq revealed hepatocyte-specific genes, such as hepatocyte nuclear factor 4 alpha ( HNF4A ), as direct targets of KRT19-CoREST. In addition, we identified forkhead box P4 as a direct activator of aberrant KRT19 expression in liver cancer. Furthermore, treatment of primary liver tumors and patient-derived xenografts in mice suggest that KRT19 expression has the potential to predict response to histone deacetylase 1 inhibitors especially in combination with lenvatinib., Conclusions: Our data show that nuclear KRT19 acts as a transcriptional corepressor through promoting the deacetylase activity of the CoREST complex, resulting in dedifferentiation of liver cancer. These findings reveal a previously unrecognized function of KRT19 in directly shaping the epigenetic landscape in cancer., (Copyright © 2024 American Association for the Study of Liver Diseases.)

Calcific myonecrosis (CM), a rare post-traumatic sequel of the lower limb, is characterized by calcified lesions. A diagnosis of CM can be difficult owing to the longtime span from the emergence of the original trauma to the onset of the symptoms of CM. This case report aimed to feature a case of a 55-year-old gentleman who presented with a progressive painful swelling in the anterolateral aspect of the right lower leg with the initial trauma arising 11 years ago. In the conservative treatment, a fluid-filled mass was formed. The histological examination of the biopsy suggested a diagnosis of CM. The patient underwent a complete debridement operation, after which vacuum sealing drainage was used to manage the space left. Three weeks later, direct wound closure was achieved. Five-year follow-ups showed an excellent outcome without recurrence. Complete surgical debridement combined with primary closure is recommended to manage CM. Cite this article as: Wang C, Hao D, Wang S. Management of calcific myonecrosis using vacuum sealing drainage: A rare case report and 5-year follow-up. Acta Orthop Traumatol Turc., 2024;58(2):135-139.