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Companies receive numerous customer inquiries and regulatory requirements while attempting to offer new services to enhance sustainability, leading in total to an increase in the number of product-related requirements. Digital Twins serve as enablers for meeting these requirements, whereas new challenges arise for companies through the introduction of Digital Twins. Digital Twins represent an order-specific configuration and must be structured differently according to requirements and thus as modularly as possible. This paper aims to provide a systemic approach with a concept for a Modular Digital Twin for generating and exploiting Product Sustainability Information to leverage sustainability potentials towards Service-oriented Business Models. The approach is concretised by means of a selected use case regarding energy-efficient production control of an automated model factory. We can show with this use case that the systemic approach with the concept of a Modular Digital Twin is applicable for energy consumption of machinery motors' simulation and for the calculation of an optimised motor speed. [ABSTRACT FROM AUTHOR]

Background: Following non-pharmaceutical interventions (NPI) lifting in 2021, an important surge in childhood lower respiratory tract infections (LRTI) was reported in several countries, raising major concerns about the middle-term consequences of such interventions. Whether this recent upsurge overwhelms the initial benefit of NPI remains unknown. Methods: We conducted an interrupted time-series analysis based on exhaustive national surveillance systems. All hospitalisations from January 2015 to March 2023 and all ambulatory visits for LRTI from a network of 110 paediatricians from June 2017 to March 2023 were included. The main outcome was the monthly incidence of children hospitalised for LRTI per 100,000 over time, assessed by a seasonally adjusted quasi-Poisson regression model. Results: We included 845,047 hospitalisations. The incidence of hospitalisation for LRTI significantly decreased during the NPI period (− 61.7%, 95% CI − 98.4 to − 24.9) and rebounded following NPI lifting, exceeding the pre-NPI baseline trend (+ 12.8%, 95% CI 6.7 to 19.0). We observed similar trends for hospitalisation due to bronchiolitis, pneumonia and pneumonia with pleural effusion, along with ambulatory LRTI. Overall, despite the recent rebound, 31,777 (95% CI, 25,375 to 38,179) hospitalisations for paediatric LRTI were averted since NPI implementation up to 2023. Conclusions: Three years after their implementation, despite an increase in LRTI incidence, the middle-term impact of NPI remains highly beneficial in preventing overall paediatric LRTI. The implementation of some societally acceptable NPI, particularly during epidemics, may be considered in the future to further reduce the burden of paediatric LRTI. [ABSTRACT FROM AUTHOR]

Aim: Height velocity is considered a key auxological tool to monitor growth, but updated height velocity growth charts are lacking. We aimed to derive new French height velocity growth charts by using a big‐data approach based on routine measurements. Methods: We extracted all growth data of children aged 1 month–18 years from the electronic medical records of 42 primary care physicians, between 1 January 1990 and 8 February 2018, throughout the French metropolitan territory. We derived annual and biannual height velocity growth charts until age 15 years by using the Lambda‐Mu‐Sigma method. These new growth charts were compared to the 1979 French and 2009 World Health Organisation (WHO) ones. Results: New height velocity growth charts were generated with 193 124 and 209 221 annual and biannual values from 80 204 and 87 260 children, respectively, and showed good internal fit. Median curves were close to the 1979 French or 2009 WHO ones, but SD curves displayed important differences. Similar results were found with the biannual height velocity growth charts. Conclusion: We produced new height velocity growth charts until age 15 years by using a big‐data approach applied to measurements routinely collected in clinical practice. These updated growth charts could help optimise growth‐monitoring performance. [ABSTRACT FROM AUTHOR]

We describe the characteristics of children hospitalized for coronavirus disease 2019 in France with a focus on the post-BA.1 Omicron period (February 2022-December 2023). We identified 3 main groups of children: those ≤90 days old (44.8%), older children with comorbidities (22.1%) and children with multisystem inflammatory syndrome (5.2%). Low vaccination coverage in these groups suggests that this burden could be alleviated with immunization., Competing Interests: A.R. reports personal fees from Pfizer and MSD outside the submitted work and nonfinancial support from Pfizer. N.O. reported receiving grants from Pfizer to his institution during the conduct of the study and travel grants from Pfizer, Sanofi and GlaxoSmithKline outside the submitted work. A.W. reports receiving personal fees from Sanofi, GSK, MSD and Pfizer and nonfinancial support from MSD. F.C.-S. reports receiving personal fees from Sanofi and GSK, and nonfinancial support from Sanofi. F.A. reports receiving personal fees from MSD, Sanofi and AstraZeneca outside the submitted work. R.C. reported receiving personal fees from Sanofi, Pfizer, MSD, Viatris and GSK; travel grants from Sanofi, Pfizer and MSD, and grants from Sanofi, Pfizer, MSD and GSK outside the submitted work. C.L. reported receiving grants from Pfizer during the conduct of the study, personal fees from Pfizer and MSD and nonfinancial support from Pfizer outside the submitted work. The other authors have no conflicts of interest to disclose., (Copyright © 2025 Wolters Kluwer Health, Inc. All rights reserved.)