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Your search keyword '"Yan, Wenju"' showing total 7 results
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7 results on '"Yan, Wenju"'

1. Design and Analysis of a Novel Type of Double Stator Switched Reluctance Wind Turbine Generator

Author

Yan, Wenju, Hu, Jiangpeng, Sun, Wenwen, Li, Hailong, Chen, Hao, Yang, Hongwei, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Jiming, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Yang, Qingxin, editor, Li, Zewen, editor, and Luo, An, editor

Published
2024
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5. Protective effect of human epicardial adipose‐derived stem cells on myocardial injury driven by poly‐lactic acid nanopillar array.

Author

Yan, Wenju, Li, Yan, Yin, Jie, Liu, Qian, Shi, Yugen, Tan, Jiayu, Wang, Yu, Zhang, Shan, Zhang, Junyi, Li, Jingxin, and Yan, Suhua

Subjects
*MYOCARDIAL injury, *STEM cells, *TYROSINE hydroxylase, *MYOCARDIAL infarction, *ACIDS
Abstract

We investigated if poly‐lactic acid (PLA) nanopillar array can trigger the differentiation of human epicardial (ADSCs) (heADSCs) into cardiomyocyte‐like cells and explored the effects of these cardiomyocyte‐like cells on myocardial infarction (MI) in vivo. PLA nanopillar array (200 nm diameter) and plain PLA film (PLA planar) induced heADSCs were marked with carboxyfluorescein. After 7 days, the expressions of myocardiocyte‐specific genes were significantly enhanced in cells seeded on PLA nanopillar array compared with that on PLA planar, especially CACNA1C, KCNH2, and MYL2 genes (p < 0.05). However, the expressions of cardiac troponin T (cTNT), KCNQ1, and KCNA5 were lower than those in PLA planar‐induced heADSCs (p < 0.05), whereas GATA4 tended to increase with time. The cells with positively stained α‐actinin and cTNT were elevated in heADSCs induced by PLA nanopillar array compared with those induced by PLA planar only (p < 0.05). In vivo experiments showed that cardiac function was improved after injecting PLA‐nanopillar array‐induced heADSCs into the ischemic heart (p < 0.05, compared with PLA planar + MI group). Furthermore, tyrosine hydroxylase density was significantly lower (p < 0.05). PLA nanopillar array directly drives the differentiation of heADSCs into cardiomyocyte‐like cells, and the induced heADSCs exhibit a protective effect on ischemic myocardium by improving cardiac function in MI rats. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Investigation on Different Stator Structures of the Axial-Radial Flux Switched Reluctance Motors

Author

Yan, Wenju, Wang, Weichao, Li, Hailong, Chen, Hao, Yu, Fengyuan, Zhang, Dong, Yang, Hongwei, and Wang, Qing

Abstract

In order to improve the torque performance and power density of switched reluctance motor, the combination of the axial flux and the radial flux is a suitable and effective method. Based on its operating principle and the characteristics of the hybrid flux structure, this article proposes the new axial-radial flux switched reluctance motors with different stator structures for electric vehicle applications. First, this article describes the topologies and operating principles of two stator structures. Then, the structural parameters of two kinds of motors are derived based on electromagnetic design principles. In order to evaluate the effects of different stator structures, the overall performance of the two proposed motors is studied using three-dimensional finite-element analysis, including the static magnetic characteristics and dynamic performance. Finally, a prototype motor is trialed, and the experimental results obtained are analyzed with the finite element results to verify the excellent performance of the proposed motor.

Published
2024
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7. Oxytocin Attenuates Sympathetic Innervation with Inhibition of Cardiac Mast Cell Degranulation in Rats after Myocardial Infarction.

Author

Yin J, Wang Y, Han W, Ge W, Yu Q, Jing Y, Yan W, Liu Q, Gong L, Yan S, Wang S, Li X, Li Y, and Hu H

Subjects
Animals, Rats, Male, Mice, Signal Transduction drug effects, Phosphatidylinositol 3-Kinases metabolism, Proto-Oncogene Proteins c-akt metabolism, Arrhythmias, Cardiac metabolism, Arrhythmias, Cardiac drug therapy, Arrhythmias, Cardiac etiology, Oxytocin pharmacology, Oxytocin metabolism, Myocardial Infarction drug therapy, Myocardial Infarction metabolism, Mast Cells drug effects, Mast Cells metabolism, Sympathetic Nervous System drug effects, Sympathetic Nervous System metabolism, Cell Degranulation drug effects, Receptors, Oxytocin metabolism, Receptors, Oxytocin antagonists & inhibitors, Rats, Sprague-Dawley
Abstract

Sympathetic hyperinnervation is the leading cause of fatal ventricular arrhythmia (VA) after myocardial infarction (MI). Cardiac mast cells cause arrhythmias directly through degranulation. However, the role and mechanism of mast cell degranulation in sympathetic remodeling remain unknown. We investigated the role of oxytocin (OT) in stabilizing cardiac mast cells and improving sympathetic innervation in rats. MI was induced by coronary artery ligation. Western blotting, immunofluorescence, and toluidine staining of mast cells were performed to determine the expression and location of target protein. Mast cells accumulated significantly in peri-infarcted tissues and were present in a degranulated state. They expressed OT receptor (OTR), and OT infusion reduced the number of degranulated cardiac mast cells post-MI. Sympathetic hyperinnervation was attenuated as assessed by immunofluorescence for tyrosine hydroxylase (TH). Seven days post-MI, the arrhythmia score of programmed electrical stimulation was higher in vehicle-treated rats with MI than in rats treated with OT. An in vitro study showed that OT stabilized mast cells via the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. Further in vivo studies on OTR-deficient mice showed worsening mast cell degranulation and worsening sympathetic innervation. OT pretreatment inhibited cardiac mast cell degranulation post-MI and prevented sympathetic hyperinnervation, along with mast cell stabilization via the PI3K/Akt pathway. SIGNIFICANCE STATEMENT: This is the first study to elucidate the role and mechanism of oxytocin (OT) in inflammatory-sympathetic communication mediated sympathetic hyperinnervation after myocardial infarction (MI), providing new approaches to prevent fatal arrhythmias., (Copyright © 2024 by The Author(s).)

Published
2024
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