8 results on '"Yang, Zuocheng"'
Search Results
2. Complement components regulates ferroptosis in CVB3 viral myocarditis by interatction with TFRC
- Author
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Yi, Lu, Yang, Yezhen, Hu, Yanan, Wu, Zhixiang, Kong, Min, Zuoyuan, Bojiao, Xin, Xiaowei, and Yang, Zuocheng
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- 2024
- Full Text
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3. Evaluating the Utility of Atypical Central Neurocytoma Classification and Treatment Strategies
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Sun, Feixia, primary, Yang, Zuocheng, additional, Kong, Ronghua, additional, and Han, Song, additional
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- 2024
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4. Epilepsy alters brain networks in patients with insular glioma.
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He, Qifeng, Yang, Zuocheng, Xue, BoWen, Song, Xinyu, Zhang, Chuanhao, Yin, ChuanDong, Li, Zhenye, Deng, Zhenghai, Sun, Shengjun, Qiao, Hui, Xie, Jian, and Hou, Zonggang
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LARGE-scale brain networks , *GLIOMAS , *FUNCTIONAL magnetic resonance imaging , *EPILEPSY - Abstract
Aims: We intend to elucidate the alterations of cerebral networks in patients with insular glioma‐related epilepsy (GRE) based on resting‐state functional magnetic resonance images. Methods: We collected 62 insular glioma patients, who were subsequently categorized into glioma‐related epilepsy (GRE) and glioma with no epilepsy (GnE) groups, and recruited 16 healthy individuals matched to the patient's age and gender to form the healthy control (HC) group. Graph theoretical analysis was applied to reveal differences in sensorimotor, default mode, visual, and executive networks among different subgroups. Results: No significant alterations in functional connectivity were found in either hemisphere insular glioma. Using graph theoretical analysis, differences were found in visual, sensorimotor, and default mode networks (p < 0.05). When the glioma located in the left hemisphere, the degree centrality was reduced in the GE group compared to the GnE group. When the glioma located in the right insula, the degree centrality, nodal efficiency, nodal local efficiency, and nodal clustering coefficient of the GE group were lower than those of the GnE group. Conclusion: The impact of insular glioma itself and GRE on the brain network is widespread. The networks altered by insular GRE differ depending on the hemisphere location. GRE reduces the nodal properties of brain networks than that in insular glioma. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Postoperative hydrocephalus is a high-risk lethal factor for patients with low-grade optic pathway glioma.
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Han, Song, Yang, Zuocheng, Wang, Liguo, Yang, Yakun, Qi, Xueling, Yan, Changxiang, and Yu, Chunjiang
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HYDROCEPHALUS , *CEREBROSPINAL fluid shunts , *GLIOMAS , *PROGNOSIS , *OVERALL survival ,MORTALITY risk factors - Abstract
To explore the prognostic factors of patients with low-grade optic pathway glioma (OPG) and the optimal treatment to reduce the incidence of postoperative hydrocephalus. This single-center study retrospectively analyzed data from 66 patients with OPGs who underwent surgery. The patients were followed, and overall survival (OS) and progression-free survival (PFS) were determined. The effects of different treatments on the hydrocephalus of patients were compared. Postoperative hydrocephalus was identified as a factor to increase the risk of mortality by 1.99-fold (p =.028). And, 5-year survival rate was significantly lower among patients with postoperative hydrocephalus (p =.027). The main factors leading to preoperative hydrocephalus in patients are large tumor volume and invasion into the third ventricle. Gross total resections (GTR) could reduce the risk of long-term hydrocephalus (p =.046). Age younger than 4 years (p =.046) and tumor invasion range/classification (p =.029) are the main factors to reduce the five-year survival rate. Postoperative radiotherapy (RT) and chemotherapy (CT) had no significant effects on OS. Extraventricular drainage (EVD) was not associated with perioperative infection (p =.798 >.05) and bleeding (p =.09 >.05). Compared with 2 stage surgery (external ventricular drainage or ventriculoperitoneal shunt (VPS) was first placed, followed by tumor resection), 1 stage surgery (direct resection of tumor) had no complication increase. Postoperative hydrocephalus is mostly obstructive hydrocephalus, and it is an important factor that reduces the OS of patients with low-grade OPGs. Surgery to remove the tumor to the greatest extent improves cerebrospinal fluid circulation is effective at reducing the incidence postoperative hydrocephalus. For patients whose ventricles are still dilated after surgery, in addition to considering poor ventricular compliance, they need to be aware of the persistence and progression of hydrocephalus. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Exosomal let-7a-5pderived from human umbilical cord mesenchymal stem cells alleviates coxsackievirus B3-induced cardiomyocyte ferroptosis via the SMAD2/ZFP36 signal axis
- Author
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Li, Xin, Hu, Yanan, Wu, Yueting, Yang, Zuocheng, Liu, Yang, and Liu, Hanmin
- Abstract
Viral myocarditis (VMC) is one of the most common acquired heart diseases in children and teenagers. However, its pathogenesis is still unclear, and effective treatments are lacking. This study aimed to investigate the regulatory pathway by which exosomes alleviate ferroptosis in cardiomyocytes (CMCs) induced by coxsackievirus B3 (CVB3). CVB3 was utilized for inducing the VMC mouse model and cellular model. Cardiac echocardiography, left ventricular ejection fraction (LVEF), and left ventricular fractional shortening (LVFS) were implemented to assess the cardiac function. In CVB3-induced VMC mice, cardiac insufficiency was observed, as well as the altered levels of ferroptosis-related indicators (glutathione peroxidase 4 (GPX4), glutathione (GSH), and malondialdehyde (MDA)). However, exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs-exo) could restore the changes caused by CVB3 stimulation. Let-7a-5pwas enriched in hucMSCs-exo, and the inhibitory effect of hucMSCs-exolet-7a-5pmimicon CVB3-induced ferroptosis was higher than that of hucMSCs-exomimic NC(NC: negative control). Mothers against decapentaplegic homolog 2 (SMAD2) increased in the VMC group’ while the expression of zinc-finger protein 36 (ZFP36) decreased. Let-7a-5pwas confirmed to interact with SMAD2messenger RNA (mRNA), and the SMAD2 protein interacted directly with the ZFP36 protein. Silencing SMAD2and overexpressing ZFP36inhibited the expression of ferroptosis-related indicators. Meanwhile, the levels of GPX4, solute carrier family 7, member 11 (SLC7A11), and GSH were lower in the SMAD2overexpression plasmid (oe-SMAD2)+let-7a-5pmimic group than in the oe-NC+let-7a-5pmimic group, while those of MDA, reactive oxygen species (ROS), and Fe2+increased. In conclusion, these data showed that ferroptosis could be regulated by mediating SMAD2expression. Exo-let-7a-5pderived from hucMSCs could mediate SMAD2to promote the expression of ZFP36, which further inhibited the ferroptosis of CMCs to alleviate CVB3-induced VMC.
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- 2024
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7. Association between TRAF1/C5 Gene Polymorphisms and IgA Vasculitis in Chinese Children.
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Yu, Meng, Yang, Yeyi, Zhang, Juan, Liu, Rui, Huang, Lihua, Wu, Jiping, Kang, Zhijuan, Zhou, Jin, and Yang, Zuocheng
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CHINESE people ,GENETIC polymorphisms ,SINGLE nucleotide polymorphisms ,NUCLEIC acids ,IMMUNOGLOBULIN A - Abstract
To investigate the association between loci rs3761847 and rs10818488 of tumor necrosis factor receptor-associated factor 1/complement C5 (TRAF1/C5) gene and the susceptibility to IgAV. 100 blood samples of children with IgAV and 100 blood samples of healthy children were collected from the Third Xiangya Hospital of Central South University from June 2017 to June 2019. The target gene fragment was amplified by polymerase chain reaction (PCR), and the single nucleic acid gene polymorphism of the gene loci was detected by PCR sequencing based typing technique. The association between gene polymorphism of each locus and susceptibility to IgAV was analyzed. There were significant differences in both genotype (P <.05) and allele frequencies (P <.05) of rs3761847 of TRAF1/C5 gene between the IgAV group and the control group.Besides, the risks of developing IgAV in children with the TT genotype was 0.495 times and in children with the C allele was 1.627 times of that in children with other genotypes and alleles, respectively (P <.05). For IgAV patients, renal involvement risk in children with CC genotype was 5.859 times of that in children with other genotypes (P <.05). There were no significant differences in genotype (P >.05) and allele frequencies (P >.05) of rs10818488 of TRAF1/C5 gene between the IgAV group and the control group. IgAV patients with TT genotype had a 3.2 times higher risk of renal involvement than those with other genotypes (P <.05). There is an association between locus rs3761847 of TRAF1/C5 gene single nucleotide polymorphisms and susceptibility to IgAV. The T allele at locus rs3761847 of TRAF1/C5 gene may be a protective factor for IgAV. The C allele at locus rs3761847 and the T allele at locus rs10818488 of TRAF1/C5 gene may be associated with kidney injury in IgAV. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Novel Compound Heterogeneous Mutations in CYB5R3 Gene Leading to Methemoglobinemia (Type I) in a Chinese Boy: Case Report and Relevant Comprehensive Analysis.
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Yang Y, Yang Y, Meng Y, Huang L, and Yang Z
- Abstract
Introduction: Recessive congenital methemoglobinemia (RCM) caused by CYB5R3 deficiency due to the mutations in the reduced nicotinamide adenine dinucleotide (NADH) cytochrome b5 reductase (CYB5R) gene is an autosomal recessive inherited disease. Clinically, it can be divided into two types, namely red blood cell affected type (RCM I) and systemically affected type (RCM II)., Case Presentation: A 5-year-old male patient was diagnosed with cyanosis for 5 years. Physical examination showed cyanosis in areas such as the lips, fingers, and toes. Laboratory examination revealed low pulse oxygen saturation (81%) and increased blood methemoglobin (23.6%). Gene testing revealed the compound heterozygous mutations in the CYB5R3 gene, c.149G>A (p.Arg50Gln) and c.331A>G (p.Lys111Glu), respectively originating from his parents. By constructing 3D models of CYB5R3 wild-type and mutant types using SWISS-MODEL software, it was found that the mutation caused significant structural abnormalities in the CYB5R protein. The relationship between CYB5R3 gene mutation sites, amino acid change, enzyme activity, and methemoglobinemia type I and II were listed and analyzed., Conclusion: A case of congenital RCM type I caused by compound heterozygous mutations in the CYB5R3 gene was reported, with c.331A>G (p.Lys111Glu) being the newly reported mutation. The homozygosity or heterozygosity of CYB5R3 gene mutations that lead to premature termination, loss of exons, and change in amino acid properties in FAD or NADH binding domains, is positively correlated with the severity (from type I to type II) of methemoglobinemia., (© 2024 S. Karger AG, Basel.)
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- 2024
- Full Text
- View/download PDF
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