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Based on the panel data of the province and municipality in 2010–2021, this paper measures the fishery eco-efficiency by using the SBM-DEA model and empirically analyses how China’s marine ranch construction improves the fishery eco-efficiency by using the double-difference fixed-effect model. The results show that, firstly, China’s marine ranch construction can improve the fishery eco-efficiency. Secondly, China’s marine ranch construction promotes fisheries eco-efficiency by improving the input efficiency of labor, fish species, fishing vessel, fishery technology extension, aquaculture area and by reducing pollutant outputs. Thirdly, the fishery eco-efficiency of the marine ranch construction region has increased annually since 2015, and technological changes, scale efficiency changes and technical efficiency changes can all contribute to the fishery eco-efficiency improvement, and increase in order. Based on the results of the empirical analyses, this paper proposes policy recommendations to improve the fishery eco-efficiency in the conjunction with the construction of marine ranch in China.

The utilization of optical and synthetic aperture radar (SAR) multi-source data to obtain better land classification results has received increasing research attention. However, there is a large property and distributional difference between optical and SAR data, resulting in an enormous challenge to fuse the inherent correlation information to better characterize land features. Additionally, scale differences in various features in remote sensing images also influence the classification results. To this end, an optical and SAR Siamese semantic segmentation network, OPT-SAR-MS2Net, is proposed. This network can intelligently learn effective multi-source features and realize end-to-end interpretation of multi-source data. Firstly, the Siamese network is used to extract features from optical and SAR images in different channels. In order to fuse the complementary information, the multi-source feature fusion module fuses the cross-modal heterogeneous remote sensing information from both high and low levels. To adapt to the multi-scale features of the land object, the multi-scale feature-sensing module generates multiple information perception fields. This enhances the network's capability to learn contextual information. The experimental results obtained using WHU-OPT-SAR demonstrate that our method outperforms the state of the art, with an mIoU of 45.2% and an OA of 84.3%. These values are 2.3% and 2.6% better than those achieved by the most recent method, MCANet, respectively. [ABSTRACT FROM AUTHOR]

Phenol-formaldehyde resins combined with polymers have a wide range of industrial applications as plugging agents for profile control and enhanced oil recovery. Due to the structural resemblance between lignin and phenol, there are possibilities for environmentally friendly phenol-formaldehyde resin manufacturing. Sulfonated lignin–based phenol-formaldehyde resin was synthesized by partially replacing phenol with lignin, which improved the utilization rate of lignin and achieved the purpose of environmental preservation and resource conservation. Partially hydrolyzed polyacrylamide is the most widely used polymer in chemical methods for enhanced oil recovery. However, the stability of reservoirs with high salt and high temperatures is weak under these conditions. To solve the problem of low oil recovery in high-salt reservoir environments, polymer flooding is adopted, which utilizes high-molecular-weight polymers to raise the viscosity of injected fluids, thereby improving sweep efficiency and altering mobility ratio between oil and injected fluid. We focus on the stability study of different molecular weights partially hydrolyzed polyacrylamide combined with sulfonated lignin – based phenol-formaldehyde resins in metal ions and surfactants. The zeta potential and hydrodynamic diameter of the partially hydrolyzed polyacrylamide – sulfonated lignin – based phenol-formaldehyde resin system in Ca2+ were measured by dynamic light scattering and static light scattering, and the dispersion stability was analyzed. The interfacial energy – modified DLVO theory was introduced to evaluate the stability of its colloidal solution, which made it possible to predict the aggregation behavior of sulfonated lignin – based phenol-formaldehyde resin and the co-migration process of metal cations in real time. [ABSTRACT FROM AUTHOR]

This study aimed to evaluate the clinical and prognostic characteristics of primary gastric gastrointestinal stromal tumors (GIST). Patients who underwent resection for primary gastric GIST between January 2002 and December 2017 were included. Recurrence-free survival (RFS) was calculated by Kaplan–Meier analysis, and Cox proportional hazards model was used to identify independent prognostic factors. Altogether, 653 patients were enrolled. The median patient age was 59 years (range 15-86 years). Open, laparoscopic, and endoscopic resections were performed in 394 (60.3%), 105 (16.1%), and 154 (23.6%) patients, respectively. According to the modified NIH consensus classification, 132 (20.2%), 245 (37.5%), 166 (25.4%), and 88 (13.5%) patients were categorized into very low-, low-, intermediate-, and high-risk, respectively. A total of 136 (20.8%) patients received adjuvant imatinib treatment. The median follow-up time was 78 months (range 4–219 months), and the estimated 5-year RFS rate was 93.0%. In all patients, tumor size and rupture, mitotic counts, and adjuvant imatinib treatment were independent prognostic factors. The prognosis of gastric GIST treated with endoscopic resection was not significantly different from that of laparoscopic or open resection after adjusting for covariates using propensity score matching (log-rank p =.558). Adjuvant imatinib treatment (HR = 0.151, 95%CI 0.055–0.417, p <.001) was a favorable prognostic factor for high-risk patients, but was not associated with prognosis in intermediate-risk patients. Patients with small gastric GISTs who successfully underwent endoscopic resection may have a favorable prognosis. Adjuvant imatinib treatment improve the prognosis of high-risk gastric GISTs, however, its use in intermediate-risk patients remains controversial. [ABSTRACT FROM AUTHOR]

Background: Procedural sedation is essential for optimizing upper gastrointestinal endoscopy, particularly in high-risk patients with multiple underlying diseases. Respiratory and circulatory complications present significant challenges for procedural sedation in this population. This non-inferiority randomized controlled trial aims to investigate the safety and comfort of remimazolam compared to propofol for procedural sedation during upper gastrointestinal endoscopy in high-risk patients. Methods: A total of 576 high-risk patients scheduled to undergo upper gastrointestinal endoscopy are planned to be enrolled in this study and randomly allocated to either the remimazolam or propofol group. The primary outcome measure is a composite endpoint, which includes (1) achieving a Modified Observer's Alertness/Sedation scale (MOAA/S) score ≤ 3 before endoscope insertion, (2) successful completion of the endoscopic procedure, (3) the absence of significant respiratory instability during the endoscopy and treatment, and (4) the absence of significant circulatory instability during the examination. The noninferiority margin was 10%. Any adverse events (AEs) that occur will be reported. Discussion: This trial aims to determine whether remimazolam is non-inferior to propofol for procedural sedation during upper gastrointestinal endoscopy in high-risk patients, regarding success rate, complication incidence, patient comfort, and satisfaction. Trial registration {2a and 2b}: Chinese Clinical Trial Registry ClinicalTrials.gov ChiCTR2200066527. Registered on 7 December 2022. [ABSTRACT FROM AUTHOR]

Introduction: Aging is one of the risk factors for the early onset of Alzheimer's disease (AD). We previously discovered that the age-dependent increase in Ubiquitin Conjugating Enzyme E2 N (UBE2N) plays a role in the accumulation of misfolded proteins through K63 ubiquitination, which has been linked to AD pathogenesis. However, the impact of UBE2N on amyloid pathology and clearance has remained unknown., Results: We observed the elevated UBE2N during the amyloid beta (Aβ) generation in the brains of 5×FAD, APP/PS1 mice, and patients with AD, in comparison to healthy individuals. UBE2N overexpression exacerbated amyloid deposition in 5×FAD mice and senescent monkeys, whereas knocking down UBE2N via CRISPR/Cas9 reduced Aβ generation and cognitive deficiency. Moreover, pharmacological inhibition of UBE2N ameliorated Aβ pathology and subsequent transcript defects in 5×FAD mice., Discussion: We have discovered that age-dependent expression of UBE2N is a critical regulator of AD pathology. Our findings suggest that UBE2N could serve as a potential pharmacological target for the advancement of AD therapeutics., Highlights: Ubiquitin Conjugating Enzyme E2 N (UBE2N) level was elevated during amyloid beta (Aβ) deposition in AD mouse and patients' brains. UBE2N exacerbated Aβ generation in the AD mouse and senescent monkey. Drug inhibition of UBE2N ameliorated Aβ pathology and cognitive deficiency., (© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)

Huntington's disease (HD) is an autosomal dominant neurodegenerative disease characterized by preferential neuronal loss in the striatum. The mechanism underlying striatal selective neurodegeneration remains unclear, making it difficult to develop effective treatments for HD. In the brains of nonhuman primates, we examined the expression of Huntingtin ( HTT ), the gene responsible for HD. We found that HTT protein is highly expressed in striatal neurons due to its slow degradation in the striatum. We also identified tripartite motif-containing 37 (TRIM37) as a primate-specific protein that interacts with HTT and is selectively reduced in the primate striatum. TRIM37 promotes the ubiquitination and degradation of mutant HTT (mHTT) in vitro and modulates mHTT aggregation in mouse and monkey brains. Our findings suggest that nonhuman primates are crucial for understanding the mechanisms of human diseases such as HD and support TRIM37 as a potential therapeutic target for treating HD.