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Herein, a visible-light-induced chiral N-heterocyclic carbene (NHC)-catalyzed asymmetric amination of ketenes has been developed. This strategy provides a convenient and facile synthetic protocol for the efficient construction of α-chiral amides under mild reaction conditions with moderate to excellent yields and stereoselectivities (up to 95% yields and 97 : 3 e.r.). Furthermore, a chiral 2-phenyl-1-propylamine derivative and (R)-ibuprofen could be obtained after simple transformations of the chiral products. [ABSTRACT FROM AUTHOR]

Herein, an N-heterocyclic carbene (NHC) catalyzed radical tandem cyclization reaction of N -allylbromodifluoroacetamides and aldehydes has been developed. This method is an efficient protocol for synthesizing α,α-difluoro-γ-lactam derivatives in moderate to good yields (27 examples, up to 88% yield and 10 : 1 dr). This strategy features mild and metal-free conditions, high efficiency, and a broad substrate scope.

Herein, an efficient ( t BuO) 2 Mg promoted [3 + 2] annulation of δ-acetoxy allenoates with N -benzylhydroxylamine has been developed. This method provides a concise and facile protocol to synthesize vinylated isoxazol-5(2 H )-one derivatives stereospecifically in a broad substrate scope with high efficiency (31 examples, up to 87% yield).