1. Syntheses of 7a-Substituted Pyrrolizidine Derivatives via Stereocontrolled Anionic Cyclization.
- Author
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Ming, Hongjun, He, Darong, Si, Shengmeng, Xu, Chao, Yuan, Yunge, Tian, Xiaoran, Hu, Zhigang, Li, Shikuo, Zhang, Hui, Huang, Fangzhi, and Chen, Yue-Lei
- Subjects
RING formation (Chemistry) ,CYCLIC compounds ,KETONES ,IMINOSUGARS ,STEREOCHEMISTRY - Abstract
This article discusses the synthesis of 7a-substituted pyrrolizidine derivatives through stereocontrolled anionic cyclization. The derivatives have potential therapeutic applications and the authors describe a new route for their synthesis using proline derivatives and epichlorohydrin. The compounds were successfully synthesized with controlled stereochemistry and characterized using spectroscopic techniques. The text provides detailed information on the reactions, yields, physical properties, and spectroscopic data of the compounds, making it a valuable resource for researchers studying organic chemistry and chemical synthesis. [Extracted from the article]
- Published
- 2024
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