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Objective: The aim of the study is to evaluate the effectiveness of pulmonary rehabilitation programs and other rehabilitation interventions in adults with asthma., Design: This is a systematic review and meta-analysis., Results: MEDLINE (PubMed), Embase, Cumulative Index to Nursing & Allied Health Literature, and CENTRAL were searched from inception to 31 May 2023. PROSPERO registration number: CRD42022331440. Thirty-six randomized controlled trials were analyzed, and only 26 were pooled in the meta-analysis because of the heterogeneity of comparisons and outcomes across the studies. Pulmonary rehabilitation, compared with education associated with breathing exercises, may result in little to no difference in the Asthma Quality of Life Questionnaire (mean difference 0.01 score, 95% confidence interval = -0.48 to 0.50, 163 participants, three studies, low certainty)., Conclusions: Our findings show that pulmonary rehabilitation, compared with education associated with breathing exercises, may result in little to no difference in the impact of asthma on health-related quality of life. Overall, the certainty of evidence was low or very low preventing any firm conclusion on the effects of single or combined rehabilitation interventions., Competing Interests: Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)