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Circular RNAs (circRNAs), a subclass of non-coding RNAs characterized by covalently closed continuous loops, play a key role in tumorigenesis and aggressiveness. However, the potential molecular mechanism of circRNAs in triple-negative breast cancer (TNBC) remains largely unknown. Exploring their roles and mechanisms in TNBC progression may help identify new diagnostic markers and therapeutic targets. In this study, we found that circ-FOXO3 was dramatically downregulated in TNBC tissues and blood samples from patients with TNBC. Notably, low circ-FOXO3 expression in TNBC tissues and bloods was associated with lymph node metastasis and unfavorable outcomes in patients with TNBC. Overexpression of circ-FOXO3 significantly inhibited the growth, invasion, and metastasis of TNBC cells both in vitro and in vivo. Moreover, we demonstrated that circ-FOXO3 was predominantly expressed in the cytoplasm and directly interacted with Wolf-Hirschhorn syndrome candidate 1 (WHSC1), thereby inhibiting WHSC1 nuclear localization and activity, resulting in the inhibition of H3K36me2 modifications at the Zeb2 promoter, ultimately inhibiting Zeb2 expression and halting TNBC growth and metastasis. Taken together, these results reveal the tumor-suppressive functions of circ-FOXO3 in inhibiting WHSC1-mediated H3K36me2 modification of Zeb2, suggesting that circ-FOXO3 could serve as a potential novel predictive prognostic biomarker and therapeutic target for TNBC. • Circ-FOXO3 expression is downregulated in TNBC tissues and cells. • Circ-FOXO3 suppresses TNBC cell proliferation and metastasis via Zeb2 inhibition. • Circ-FOXO3 inhibits TNBC progression by interacting with WHSC1 and inhibiting the WHSC1-H3K36me2-Zeb2 signaling pathway. [ABSTRACT FROM AUTHOR]

SiC/multi-walled carbon nanotube (MWCNT) composites are considered to be promising materials for high-temperature electromagnetic wave (EMW) absorption due to their strong thermal stability and tunable dielectric properties. However, the EMW absorption performance of these composites is limited by poor impedance matching. This study proposes a novel multiscale structure synergistic regulation approach to enhance EMW absorption performance, which involves constructing a heterointerface structure and a triple periodic minimal surface (TPMS) meta-structure. The addition of a SiO 2 shell as an impedance layer to the SiC/MWCNT core to improve the intrinsic impedance. Meanwhile, the heterointerface between the core-shell structure leads to multiple interface polarization, significantly enhancing EMW energy dissipation. Consequently, the effective absorption bandwidth (EAB) of SiO 2 –SiC/MWCNT composites increased from 0.88 to 4.56 GHz. Furthermore, a TPMS meta-structure, fabricated by three-dimensional (3D) printing and sol infiltration technology, is developed to further improve impedance matching with the equivalent electromagnetic effect. Simulation and experimental results demonstrate that the SiO 2 –SiC/MWCNT TPMS meta-structure exhibits broadband EMW absorption performance, with the EAB reaching 7.2 GHz. This improvement is attributed to the synergistic regulation of the heterointerface structure and TPMS meta-structure, which provides a good balance between the requirements of electromagnetic loss and impedance matching. Additionally, the composites exhibit excellent oxidation resistance, as their EAB remains almost unchanged after exposure to 1000 °C for 6 h. This research offers a new design paradigm for ultrabroadband design of the nonmagnetic high-temperature absorbing materials. [Display omitted] [ABSTRACT FROM AUTHOR]

[Display omitted] • Near defect-free and defect-rich UiO-66-type MOFs were successfully prepared. • Affecting mechanism of defects on CO 2 capture performance was elucidated. • Importance of thermal treatment for CO 2 capture performance was illustrated. • Necessity of identifying local fine structure for CO 2 capture evaluation was noted. Carbon capture and storage (CCS) technology is currently an essential response to the global warming problem caused by excessive CO 2 emissions. Efficient and reproducible adsorbents for flue gas treatment play an important role in CCS technology, and metal–organic frameworks (MOFs) are considered to be ideal candidates by virtue of their designable CO 2 sorption sites. However, carbon capture performance evaluation and reproducibility of MOFs still hinder their application promotion in industrial production. In this work, an extended UiO-66-type MOF based on 1,4-naphthalenedicarboxylate, was successfully synthesized in both a near defect-free form (UiO-66N) and a defect-rich form (DUiO-66N), for exploring the influence of crystalline defects and thermal treatments on carbon capture performance. Although powder X-ray diffraction showed that UiO-66N and DUiO-66N possessed the same crystalline phase, transmission electron microscopy, thermalgravimetric analyse and gas/dye sorption confirmed the presence of crystalline defects and the variation of porosity in DUiO-66N. CO 2 sorption isotherms and flue gas breakthrough experiments revealed the defect-induced improved carbon capture performance, which was also supported by density functional theory. Meanwhile, the metastability of defects required low thermal treatment temperatures for activation and regeneration thus maintaining the superior carbon capture performance. These findings suggested that in reproducing and evaluating the carbon capture performance of MOFs, it cannot rely only on the global crystalline phase judgment, but needs to identify the local fine structure as well as optimize activation and regeneration conditions. [ABSTRACT FROM AUTHOR]