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The way individuals handle daily stressors can significantly influence their mental health. Those who struggle with emotion regulation are especially vulnerable to the negative effects of stress. This study explored the role of catastrophizing, a maladaptive emotion regulation strategy, in shaping the relationships between daily stress responses and depressive symptoms. A total of 75 healthy college students participated in the study. We adopted an Ecological Momentary Assessment protocol over 14 consecutive days to capture the day‐to‐day dynamics of stress reactivity and recovery. Our findings indicate that individuals with higher levels of catastrophizing exhibited increased daily stress reactivity and delayed daily stress recovery, consequently raising their likelihood of experiencing amplified depressive symptoms. In contrast, those with lower levels of catastrophizing did not experience the same negative effects of increased daily stress reactivity on their mental health. These results enhance understanding of how real‐life stressors contribute to the development of mental health issues and underscore the importance of adaptive emotion regulation for improved overall health and well‐being. [ABSTRACT FROM AUTHOR]

The article discusses personalized therapy for endometriosis based on the expression of estrogen receptors α (ERα) and β (ERβ). Endometriosis is a chronic disease characterized by the growth of endometrial tissue outside the uterus, causing pain and infertility. Current treatment options include surgery and estrogen suppression therapy, but they have limitations and side effects. The study found that ovarian endometrioma (OMA) subtype of endometriosis showed the most significant response to estrogen suppression treatment by affecting ESR2. However, further research is needed to validate these findings and develop personalized treatments for different subtypes of endometriosis. [Extracted from the article]

The quantum digital signature (QDS) has become a popular research topic in the field of quantum information, due to its information-theoretic security on signing signatures. However, weak coherent sources are often utilized as light sources in most previous QDS protocols, resulting in relative limited secure transmission distance. Here, we propose a four-intensity decoy-state QDS scheme based on heralded single-photon sources (HSPS) and present a concise security analysis in the finite-size scenario. Furthermore, we carry out corresponding experimental demonstrations, and successfully sign messages at 14.4 dB and 24.4 dB, verifying the good performance of implementing QDS with HSPS. [ABSTRACT FROM AUTHOR]

A reliable and robust colorimetric assay for highly selective detection of intact S. aureus employing nanoceria as chromatic agents. [Display omitted] • Glucose oxidase was employed to in situ produce H 2 O 2 in immunoassay. • Stable nanoceria was used as quantitative chromogenic indicators. • Capture antibody-bacteria-aptamer configuration was adopted in this assay. • The immunoassay has demonstrated functionality for S. aureus detection in real samples. Rapid and reliable detection of foodborne pathogens is a key requirement for food safety. Traditional rapid ELISA methods assessed by the ability of horseradish peroxidase to oxidize a chromogenic substrate such as 3, 3′, 5, 5′-tetramethylbenzidine in the presence of H 2 O 2 may result in the high rate of negative responses because of the instability of H 2 O 2 and product. Here, we report the use of redox active nanoceria as colorimetric indicator in immunoassay taking Staphylococcus aureus as a model. The nanoceria is fully water-soluble and can be stored as least 90 days in the refrigerator while maintaining the same performance. Moreover, it does not require external H 2 O 2 , as glucose oxidase used in the immunoassay can catalyze the oxidation of glucose to produce H 2 O 2 in situ , which is more robust in signal readout. Taken together, these results demonstrate that nanoceria are potentially suitable as colorimetric substrate in the development of novel enzyme immunoassays. [ABSTRACT FROM AUTHOR]

Cervical cancer (CC) is the fourth most common cancer among women worldwide. NLR Family CARD Domain Containing 5 (NLRC5) plays an important role in tumorigenesis. However, its effect and mechanism in CC remains unclear. In this study, we aimed to investigate the function of NLRC5 in CC. NLRC5 was found to be down-regulated in CC tissues compared with normal cervical tissues. However, patients with higher NLRC5 expression had better prognosis, patients with higher age, HPV infection, lymph node metastasis, recurrence and histological grade had worse prognosis. Univariate and multivariate analyses showed NLRC5 to be a potential prognostic indicator for CC. Pearson correlation analysis showed that NLRC5 might exert its function in CC through autophagy related proteins, especially LC3. In vitro experiments demonstrated that NLRC5 inhibited LC3 levels and promoted the proliferation, migration, and invasion of CC cells by activating the PI3K/AKT signaling pathway. Treatment with LY294002 reversed the above phenotype. Taken together, our finding suggested that NLRC5 would participate in cervical tumorigenesis and progression by regulating PI3K/AKT signaling pathway. In addition, NLRC5 and LC3 combined as possible predictors in CC. [ABSTRACT FROM AUTHOR]

To comprehend the intricate interplay of five common food polysaccharides, κ-Carrageenan (KC), konjac glucomannan (KGM), locust bean gum (LBG), low-acyl gellan gum (LAG), and sodium alginate (SA), within composite polysaccharide gels, widely employed for textural modulation and flavor enhancement. This study systematically modulates the quantities of these five polysaccharides to yield six distinct multi-polysaccharide gels. The unique impact of each polysaccharide on the overall quality of composite gels were studied by thermostability, microstructure, water-holding capacity (WHC), texture, and sensory attributes. The findings unequivocally manifest the phenomenon of thermoreversible gelation in all composite gels, except for the KC-devoid sample, which displayed an inability to solidify. Notably, KGM, LBG, and LAG emerged as pivotal enhancers of the network structure in these composite gels, while SA was identified as a promotor of layered structure, resulting in a reduction of surface hardness. Leveraging principal component analysis (PCA) to analyzed 14 critical evaluation parameters of the five multi-polysaccharide gels, revealing the order as follows: KC > KGM > SA > LAG > LBG. These findings would imparts valuable insights into the pragmatic utilization of multi-polysaccharide gels for the development of food products (e.g. Bobo balls in milk tea) with tailored textural and sensory attributes. [Display omitted] • Quaternary/quinary polysaccharide gels based on KC, KGM, LBG, LAG and SA prepared • Different polysaccharides affect gel microstructure and texture differently • KGM, LBG and LAG enhance the gel network while SA promotes a layered structure • Polysaccharides' effects on composite gel quality follow KC > KGM > SA > LAG > LBG [ABSTRACT FROM AUTHOR]

A simple, sensitive dual-emission probe was developed for the detection of phosphate (Pi). The probe Tb-BTB/DPA was synthesized by mixing dual-ligand, 1,3,5-tri(4-carboxyphenyl) benzene (H3BTB) and dipicolinic acid (DPA), with metal ions Tb3+ in ethanol–water solution at 40℃ for 2 h. Tb-BTB/DPA exhibits two emission peaks, the emission at 362 nm is attributed to H3BTB, an energy transfer between Tb3+ nodes, and DPA further enhances the fluorescence of Tb3+ at 544 nm. Pi competes with ligand H3BTB to coordinate Tb3+, resulting in partial collapse of the Tb-BTB/DPA structure and interrupting the electron transfer between H3BTB and Tb3+. Therefore, the emission at 362 nm is enhanced, while the emission at 544 nm is unchanged, and a ratiometric fluorescence method is developed to detect Pi. Tb-BTB/DPA exhibits good linearity within the Pi concentration range (0.1–50 µmol/L), and the detection limit was 25.8 nmol/L. This study provides a new way to prepare probes with dual emission sensing properties. [ABSTRACT FROM AUTHOR]

The innate immune molecule NLR family CARD domain-containing 5 (NLRC5) plays a significant role in endometrial carcinoma (EC) immunosurveillance. However, NLRC5 also plays a protumor role in EC cells. Mismatch repair gene deficiency (dMMR) can enable tumors to grow faster and also can exhibit high sensitivity to immune checkpoint inhibitors. In this study, we attempted to determine whether NLRC5-mediated protumor role in EC is via the regulation of dMMR. Our findings revealed that NLRC5 promoted the proliferation, migration, and invasion abilities of EC cells and induced the dMMR status of EC in vivo and in vitro. Furthermore, the mechanism underlying NLRC5 regulated dMMR was also verified. We first found NLRC5 could suppress nuclear factor-kappaB (NF-κB) pathway in EC cells. Then we validated that the positive effect of NLRC5 in dMMR was restricted when NF-κB was activated by lipopolysaccharides in NLRC5-overexpression EC cell lines. In conclusion, our present study confirmed the novel NLRC5/NF-κB/MMR regulatory mechanism of the protumor effect of NLRC5 on EC cells, thereby suggesting that the NLRC5-mediated protumor in EC was depend on the function of MMR. [ABSTRACT FROM AUTHOR]

Background: Modified polysaccharides have greatly expanded applications in comparison with native polysaccharides due to their improved compatibility and interactions with proteins and active compounds in food‐related areas. Nonetheless, there is a noticeable dearth of research concerning the utilization of carboxymethyl starch (CMS) as a microcapsule wall material in food processing, despite its common use in pharmaceutical delivery. The development of an economical and safe embedding carrier using CMS and gelatin (GE) holds immense importance within the food‐processing industry. In this work, the potential of innovative coacervates formed by the combination of GE and CMS as a reliable, stable, and biodegradable embedding carrier is evaluated by turbidity measurements, thermogravimetric analysis (TGA), X‐ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and rheological measurements. Results: The results indicate that GE‐CMS coacervates primarily resulted from electrostatic interactions and hydrogen bonding. The optimal coacervation was observed at pH 4.6 and with a GE/CMS blend ratio of 3:1 (w/w). However, the addition of NaCl reduced coacervation and made it less sensitive to temperature changes (35–55 °C). In comparison with individual GE or CMS, the coacervates exhibited higher thermal stability, as shown by TGA. X‐ray diffraction analysis shows that the GE‐CMS coacervates maintained an amorphous structure. Rheological testing reveals that the GE‐CMS coacervates exhibited shear‐thinning behavior and gel‐like properties. Conclusion: Overall, attaining electroneutrality in the mixture boosts the formation of a denser structure and enhances rheological properties, leading to promising applications in food, biomaterials, cosmetics, and pharmaceutical products. © 2023 Society of Chemical Industry. [ABSTRACT FROM AUTHOR]

Weather data errors affect energy management by influencing the accuracy of building energy predictions. This study presents a long short-term memory (LSTM) prediction model based on the "Energy Detective" dataset (Shanghai, China) and neighboring weather station data. The study analyzes the errors of different weather data sources (Detective and A) at the same latitude and longitude. Subsequently, it discusses the effects of weather errors from neighboring weather stations (Detective, A, B, C, and D) on energy forecasts for the next hour and day including the selection process for neighboring weather stations. Furthermore, it compares the forecast results for summer and autumn. The findings indicate a correlation between weather errors from neighboring weather stations and energy consumption. The median R-Square for predicting the next hour reached 0.95. The model's predictions for the next day exhibit a higher Prediction Interval Mean Width (139.0 in summer and 146.1 in autumn), indicating a greater uncertainty. [ABSTRACT FROM AUTHOR]

Aggregation-induced electrochemiluminescence (AIECL) technology has aroused widespread interest due to the significant improve in ECL response by solving the problems of aggregation-caused quenching and poor water solubility of the luminophore. However, the existing AIECL emitters still suffer from low ECL efficiency, additional coreactants and complex synthesis steps, which greatly limit their applications. Herein, luminol, as a kind of AIE molecule, was assembled with Zn2+ nodes to obtain a novel microflower-like Zinc-luminol metal-organic gel (Zn-MOG) by one-step method. In the light of the strong affinity of N atoms in luminol ligand to Zn2+, Zn-MOG with vigorous viscosity and stability can be formed immediately after vortex oscillation, overcoming the main difficulties of the complicated synthesis steps and poor film-forming performance encountered in current AIECL materials. Impressively, an AIECL resonance energy transfer (RET) biosensor was constructed using Zn-MOG as a donor and Alexa Fluor 430 as an acceptor in combination with DNA-Fuel-driven target recycling amplification for the ultrasensitive detection of PiRNA-823. The fabricated biosensor exhibited a wide linear relationship in the range of 100 aM to 100 pM and a detection limit as low as 60.0 aM. This work is the first to realize the construction of ECL emitters using the AIE effect of luminol, which provides inspiration for the design of AIECL systems without adding coreactants. [ABSTRACT FROM AUTHOR]

Metal organic gels (MOGs) are a new kind of intelligent soft materials with excellent luminescence properties. However, MOGs with dual electrochemiluminescence (ECL) properties have not been reported. In this study, using Eu3+ as metal node, 4′-(4-carboxyphenyl)-2,2′:6′,2″-terpyridine (Hcptpy) and Luminol as organic ligands, a novel dual-ligand Europium-organic gels (Eu-L-H MOGs) were prepared by simple mixing at room temperature. On the one hand, Eu-L-H MOGs could exhibit strong and stable anodic ECL signals in the phosphate buffered saline (PBS) without the addition of co-reactants, which came from the blue emission of Luminol. On the other hand, using K 2 S 2 O 8 as a cathodic co-reactant, Eu-L-H MOGs produced cathodic signals, which were derived from the red emission of Eu sensitized by Hcptpy through the antenna effect. Based on the independent dual ECL signals of Eu-L-H MOGs, we selected Alexa Flour 430 as the receptor and anodic ECL emission of Eu-L-H MOGs as the donor to construct the ECL resonance energy transfer (ECL-RET) ratio biosensor, which utilized exonuclease III assisted DNA cycle amplification to achieve ultrasensitive detection of the I27L gene. The detection linearity of I27L ranged from 1 fM to 10 nM, with a detection limit as low as 284 aM. This study developed a straightforward technique for obtaining a single luminescent material with dual signals, and further broadened the analytical application of MOGs in the realm of ECL. [ABSTRACT FROM AUTHOR]