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• Two poorly performing HCIC ligands were utilized to construct a dual-ligand system. • The dual-ligand system exhibited superior static and dynamic adsorption capabilities. • Molecular docking is used as an auxiliary tool to explain differences in selectivity. • The dual-ligand system separated antibodies from human serum with better performance. In conventional chromatographic ligand screening, underperforming ligands are often dismissed. However, this practice may inadvertently overlook potential opportunities. This study aims to investigate whether these underperforming ligands can be repurposed as valuable assets. Hydrophobic charge-induction chromatography (HCIC) is chosen as the validation target for its potential as an innovative chromatographic mode. A novel dual-ligand approach is employed, combining two suboptimal ligands (5-Aminobenzimidazole and Tryptamine) to explore enhanced performance and optimization prospects. Various dual-ligand HCIC resins with different ligand densities were synthesized by adjusting the ligand ratio and concentration. The resins were characterized to assess appearance, functional groups, and pore features using SEM, FTIR, and ISEC techniques. Performance assessments were conducted using single-ligand mode resins as controls, evaluating the selectivity against human immunoglobulin G and human serum albumin. Static adsorption experiments were performed to understand pH and salt influence on adsorption. Breakthrough experiments were conducted to assess dynamic adsorption capacity of the novel resin. Finally, chromatographic separation using human serum was performed to evaluate the purity and yield of the resin. Results indicated that the dual-ligand HCIC resin designed for human antibodies demonstrates exceptional selectivity, surpassing not only single ligand states but also outperforming certain high-performing ligand types, particularly under specific salt and pH conditions. Ultimately, a high yield of 83.9 % and purity of 96.7 % were achieved in the separation of hIgG from human serum with the dual-ligand HCIC, significantly superior to the single-ligand resins. In conclusion, through rational design and proper operational conditions, the dual-ligand mode can revitalize underutilized ligands, potentially introducing novel and promising chromatographic modes. [ABSTRACT FROM AUTHOR]

This paper introduces an innovative structure for a self-restrained grid shear wall with diagonal CFRP-steel composite strips. Steel and CFRP strips are interwoven to enhance the structural integrity of the shear wall. Quasi-static tests are initially conducted on two shear wall specimens with and without diagonal CFRP-steel composite strips. Subsequently, a finite element model is established to represent the self-restrained grid shear wall with diagonal CFRP-steel composite strips. This model is helpful for exploring the influence of composite strips arrangement on the performance of shear walls. Furthermore, a prediction formula is developed to estimate the load-bearing capacity of the CFRP-steel composite strips grid shear wall. The test results show that the yield bearing capacity, ultimate bearing capacity, stiffness and energy dissipation capacity of the specimens increase by 46.6%, 58.2%, 43.6%, and 16.3% respectively after the replacement of composite strips. In addition, the results of finite element simulation indicate that the diagonal arrangement exhibits the highest efficiency in the use of CFRP materials among three reinforced structural forms-diagonal, spaced, and fully arranged composite strips. This arrangement is also the most economical and has the least adverse influence on the internal forces of the frame columns. • Completely discrete steel slit shear wall into steel plate strips. • The steel and CFRP strips are interwoven to enhance the seismic performance of the shear wall. • The effects of different composite strip arrangements are investigated. • The prediction formula of the ultimate bearing capacity of the grid shear wall with CFRP-steel composite strips has been derived. [ABSTRACT FROM AUTHOR]

This paper introduces a novel aluminum honeycomb sandwich panel buckling-restrained steel plate shear wall (HCSP-SPSW) that used honeycomb core sandwich panels (HCSP) as restraining members. Compared with the traditional concrete restraining panel, HCSP is lighter, more rigid, and offers additional functions such as energy and sound absorption, increasing functionality while effectively restraining out-of-plane buckling deformation of the wall panel. Quasi-static cyclic loading tests were initially conducted on two 1/3 scaled specimens to study their shear performance. Second, a finite element (FE) model is established and validated, and parameters such as chunking and honeycomb core dimensions are analyzed. Furthermore, an equation for calculating the bearing capacity of HCSP is derived and confirmed through the finite element analysis. The results reveal that, when the out-of-face equivalent modulus of HCSP is 5945.51 MPa, HCSP-SPSW improves the load carrying capacity by 16.42% and increases energy consumption by 80.54% compared to the thin steel plate shear wall (SPSW), and achieves the requirement of complete buckling restrained behavior. The effect of partitioning on shear bearing capacity and energy dissipation is minimal when the number of bolts and edge spacing remains constant. [ABSTRACT FROM AUTHOR]