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Your search keyword '"Zhao, Bingyue"' showing total 5 results
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5 results on '"Zhao, Bingyue"'

3. Synthesis of Selenocyanated Indoles via PhICl2‐Induced Electrophilic Intramolecular Cyclization of 2‐Alkynylanilines or 2‐Alkenylanilines.

Author

Xu, Lingzhi, Zhao, Bingyue, Zhao, Hui, Zhang, Jianing, Li, Jinqu, and Du, Yunfei

Subjects
RING formation (Chemistry), INDOLE compounds, BENZENE, AXIOMS, CHLORIDES
Abstract

The 3‐selenocyanato‐substituted indoles were readily synthesized via (dichloroiodo)benzene (PhICl2)‐induced reaction of 2‐alkynylanilines or 2‐alkenylanilines with KSeCN in MeCN under metal‐free conditions. The reaction sequence was postulated to encompass the formation of a reactive selenocyanogen chloride species, generated in situ from the reaction of PhICl2 and KseCN, followed by electrophilic addition and intramolecular cyclization steps. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Hook-Like DNAzyme-Activated Autocatalytic Biosensor for the Universal Detection of Pathogenic Bacteria

Author

Liu, Yaqi, Shi, Yulong, Wang, Siyuan, Liu, Sijia, Shang, Min, Zhao, Bingyue, Liu, Hanghang, Yang, Changying, Wang, Fuan, Kwok, Chun Kit, and Wang, Huimin

Abstract

DNAzyme-based assays have found extensive utility in pathogenic bacteria detection but often suffer from limited sensitivity and specificity. The integration of a signal amplification strategy could address this challenge, while the existing combination methods require extensive modification to accommodate various DNAzymes, limiting the wide-spectrum bacteria detection. We introduced a novel hook-like DNAzyme-activated autocatalytic nucleic acid circuit for universal pathogenic bacteria detection. The hook-like connector DNA was employed to seamlessly integrate the recognition element DNAzyme with the isothermal enzyme-free autocatalytic hybridization chain reaction and catalytic hairpin assembly for robust exponential signal amplification. This innovative autocatalytic circuit substantially amplifies the output signals from the DNAzyme recognition module, effectively overcoming DNAzyme’s inherent sensitivity constraints in pathogen identification. The biosensor exhibits a strong linear response within a range of 1.5 × 103to 3.7 × 107CFU/mL, achieving a detection limit of 1.3 × 103CFU/mL. Noted that the sensor’s adaptability as a universal detection platform is established by simply modifying the hook-like connector module, enabling the detection of various pathogenic bacteria of considerable public health importance reported by the World Health Organization, including Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, and Salmonella typhimurium. Additionally, the specificity of DNAzyme in bacterial detection is markedly improved due to the signal amplification process of the autocatalytic circuit. This hook-like DNAzyme-activated autocatalytic platform presents a versatile, sensitive, and specific approach for pathogenic bacteria detection, promising to significantly expand the applications of DNAzyme in bacteria detection.

Published
2024
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5. Effects of Mozart-Orff parent-child music therapy among mothers and their preschool children with autism spectrum disorder: A mixed-methods randomised controlled trial.

Author

He Y, Wong A, Zhang Y, Lin J, Li H, Zhao B, Chen T, Huang S, Hu R, and Liu G

Subjects
Humans, Female, Child, Preschool, Male, Adult, Mother-Child Relations, Stress, Psychological therapy, Applied Behavior Analysis, Treatment Outcome, Autism Spectrum Disorder therapy, Autism Spectrum Disorder psychology, Music Therapy methods, Mothers psychology
Abstract

Background: Autism spectrum disorder (ASD) negatively impacts mental health, particularly in mothers of autistic children who experience heightened stress. Applied behaviour analysis (ABA) and music therapy are recognised interventions for improving ASD symptoms. However, the specific benefits of parent-child music therapy and ABA for autistic children and their mothers remain uncertain. This study evaluated the effects of parent-child music therapy on preschool autistic children and their mothers., Method: A randomised controlled trial was conducted with 100 mother-child pairs assigned to either the control group receiving ABA or the intervention group receiving both music therapy and ABA. Qualitative interviews were conducted post-intervention for 12 mothers., Results: Children in the intervention group exhibited lower scores for ASD symptoms than those in the control group. Moreover, mothers in the intervention group demonstrated reduced dysfunctional parent-child interaction, lower overall parental stress, significantly improved family functioning, and increased levels of hope compared with those in the control group. Mothers held positive views regarding music therapy., Conclusions: Combining ABA with parent-child music therapy can alleviate ASD symptoms in children and reduce stress in mothers. Improved parent-child interaction and enhanced family functioning further support the benefits of this combined approach. Parent-child music therapy, combined with ABA demonstrated positive outcomes for autistic children, including reduced ASD symptoms, improved parent-child interaction, decreased parental stress, enhanced family functioning, and increased hope. These findings highlight the potential of incorporating music therapy as a valuable component in the comprehensive treatment of ASD., Trial Registration: This study was registered in the Chinese Clinical Trial registry (05/07/2021, ChiCTR2100048261, https://www.chictr.org.cn/showproj.html?proj=128957 ). Ethical approval was obtained from the Research Ethics Committee of Fujian Medical University and the study hospital (Fujian Provincial Maternity and Child Health Hospital; 2017 - 105), and informed consent was obtained from all subjects and/or their legal guardian(s)., (© 2024. The Author(s).)

Published
2024
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