Search

Cryogenic Electron Tomography (CryoET) is a useful imaging technology in structural biology that is hindered by its need for manual annotations, especially in particle picking. Recent works have endeavored to remedy this issue with few-shot learning or contrastive learning techniques. However, supervised training is still inevitable for them. We instead choose to leverage the power of existing 2D foundation models and present a novel, training-free framework, CryoSAM. In addition to prompt-based single-particle instance segmentation, our approach can automatically search for similar features, facilitating full tomogram semantic segmentation with only one prompt. CryoSAM is composed of two major parts: 1) a prompt-based 3D segmentation system that uses prompts to complete single-particle instance segmentation recursively with Cross-Plane Self-Prompting, and 2) a Hierarchical Feature Matching mechanism that efficiently matches relevant features with extracted tomogram features. They collaborate to enable the segmentation of all particles of one category with just one particle-specific prompt. Our experiments show that CryoSAM outperforms existing works by a significant margin and requires even fewer annotations in particle picking. Further visualizations demonstrate its ability when dealing with full tomogram segmentation for various subcellular structures. Our code is available at: https://github.com/xulabs/aitom, Comment: This preprint has not undergone peer review or any post-submission improvements or corrections. The Version of Record of this contribution will be published in MICCAI 2024

Remarkable strides have been made in reconstructing static scenes or human bodies from monocular videos. Yet, the two problems have largely been approached independently, without much synergy. Most visual SLAM methods can only reconstruct camera trajectories and scene structures up to scale, while most HMR methods reconstruct human meshes in metric scale but fall short in reasoning with cameras and scenes. This work introduces Synergistic Camera and Human Reconstruction (SynCHMR) to marry the best of both worlds. Specifically, we design Human-aware Metric SLAM to reconstruct metric-scale camera poses and scene point clouds using camera-frame HMR as a strong prior, addressing depth, scale, and dynamic ambiguities. Conditioning on the dense scene recovered, we further learn a Scene-aware SMPL Denoiser to enhance world-frame HMR by incorporating spatio-temporal coherency and dynamic scene constraints. Together, they lead to consistent reconstructions of camera trajectories, human meshes, and dense scene point clouds in a common world frame. Project page: https://paulchhuang.github.io/synchmr, Comment: CVPR 2024

In NeRF-aided editing tasks, object movement presents difficulties in supervision generation due to the introduction of variability in object positions. Moreover, the removal operations of certain scene objects often lead to empty regions, presenting challenges for NeRF models in inpainting them effectively. We propose an implicit ray transformation strategy, allowing for direct manipulation of the 3D object's pose by operating on the neural-point in NeRF rays. To address the challenge of inpainting potential empty regions, we present a plug-and-play inpainting module, dubbed differentiable neural-point resampling (DNR), which interpolates those regions in 3D space at the original ray locations within the implicit space, thereby facilitating object removal & scene inpainting tasks. Importantly, employing DNR effectively narrows the gap between ground truth and predicted implicit features, potentially increasing the mutual information (MI) of the features across rays. Then, we leverage DNR and ray transformation to construct a point-based editable NeRF pipeline PR^2T-NeRF. Results primarily evaluated on 3D object removal & inpainting tasks indicate that our pipeline achieves state-of-the-art performance. In addition, our pipeline supports high-quality rendering visualization for diverse editing operations without necessitating extra supervision.