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This paper conducts an analysis of the site selection methods for power grid material distribution centers. It proposes the fundamental principles for site selection and organizes and compares representative models and commonly used methods in site selection issues. Taking the establishment and solving process of the site selection model for power grid material distribution centers as an example, the specific methods and procedures of Sparrow Search Algorithm applied to site selection problems are explained, and analyzes the shortcomings of this method. Finally, building upon the comparison and summary of simulated annealing algorithm and Sparrow Search Algorithm in the preceding sections, this paper combines their strengths to propose an approach for optimizing the solution method that is, using the former to update the iterative optimal solution of the latter, in order to reduce the risk of falling into local optimization, enhance the accuracy of problem-solving, and improve distribution efficiency. This contributes as a reference for similar site planning and decision-making processes.

Despite exhibiting potent anticancer activity, the strong hemolytic properties of melittin (MEL) significantly restrict its delivery efficiency and clinical applications. To address this issue, we have devised a strategy wherein homologous dopamine (DA), an essential component of bee venom, is harnessed as a vehicle for the synthesis of MEL–polydopamine (PDA) nanoparticles (MP NPs). The ingenious approach lies in the fact that MEL is a basic polypeptide, and the polymerization of DA is also conducted under alkaline conditions, indicating the distinctive advantages of PDA in MEL encapsulation. Furthermore, MP NPs are modified with folic acid to fabricate tumor-targeted nanomedicine (MPF NPs). MPF NPs can ameliorate the hemolysis of MEL in drug delivery and undergo degradation triggered by high levels of reactive oxygen species (ROS) within solid tumors, thereby facilitating MEL release and subsequent restoration of anticancer activity. After cellular uptake, MPF NPs induce cell apoptosis through the PI3K/Akt-mediated p53 signaling pathway. The tumor growth inhibitory rate of MPF NPs in FA receptor-positive 4T1 and CT26 xenograft mice reached 78.04% and 81.66%, which was significantly higher compared to that in FA receptor-negative HepG2 xenograft mice (45.79%). Homologous vehicles provide a new perspective for nanomedicine design. [ABSTRACT FROM AUTHOR]

Global macroeconomic development is faced with great uncertainty, especially the repeated impact of COVID-19, which exacerbate the challenges. This study explores the impact of Internet development on the resilience of cities. In the first place, a theoretical model is used to analyse how Internet development affects productivity and further influences urban economic resilience. Based on this, a long-differences model is established for empirical analysis. The study found that improving Internet development is an important step enhancing urban economic resilience. The results provide new perspectives and evidence for the study of urban economic resilience. [ABSTRACT FROM AUTHOR]

To study the biocompatibility of nanohydroxyapatite (nmHA)-SiO 2 fiber material and its efficacy in guided bone regeneration. ① The cytotoxicity of the nmHA-SiO 2 fiber material to MC3T3-E1 cells was determined by CCK-8 assay. The adhesion of cells on the surface of the material was observed. ② Bone defects were prepared in the skull of three groups of New Zealand white rabbits. The following treatments were administered: implantation of nmHA-SiO 2 , implantation of Bio-Oss, and no treatment. The defects were then covered with nmHA-SiO 2 membrane or Hai'ao oral repair membrane. Animal samples were analyzed by gross observation, micro-computed tomography, hematoxylin-eosin staining and Masson staining. The data were statistically analyzed by multivariate analysis of variance to evaluate the repair of bone defects. ① The nmHA-SiO 2 fiber material has suitable biocompatibility. ② The nmHA-SiO 2 fiber material performed more effectively as a barrier membrane than other bone substitute materials in GBR model rabbits.

The simultaneous application of photothermal therapy (PTT) and photodynamic therapy (PDT) offers substantial advantages in cancer treatment. However, their synergistic anticancer efficacy is often limited by tumor hypoxia, and thermotolerance induced by high expression of heat shock proteins (HSP). Fortunately, hydrogen sulfide (H 2 S), known for its direct cytotoxic effect on tumor cells, has been recognized for its ability to enhance PTT and PDT. The effectiveness of H 2 S in these therapies is challenged by its low loading efficiency, poor stability, and short diffusion distance. To address these issues, a nanoscale emulsion drop template created through the salting-out effect is employed to construct a robust H 2 S delivery system. Polydopamine (PDA), chosen for its interfacial polymerization tendency and excellent photothermal conversion rate, is utilized as a carrier for the H 2 S donor (ADT) and Zinc phthalocyanine (ZnPc) to fabricate a novel nanomedicine termed APZ NPs. The temperature-responsive APZ NPs are designed to release H 2 S during the PTT process. Elevated H 2 S levels promoted vasodilation, thereby enhancing the enhanced permeability and retention effect (EPR) of APZ NPs within solid tumors. This strategy effectively alleviated tumor hypoxia by disrupting the mitochondrial respiratory chain and mitigated tumor cell heat tolerance by inhibiting HSP expression., (© 2024 Wiley‐VCH GmbH.)