Recent studies have revealed the potential of 2D moiré superlattices as a condensed matter quantum simulator. The realization of different lattice model Hamiltonians in moiré superlattices has become the focus of researches. Here, it shows that, compared to bilayer moiré superlattices where there is only one interface, the interference between moiré patterns at different interfaces in 2D multilayer structures allows the physical realization of more complicated lattice models. The concept is demonstrated by trilayer moiré superlattices (TMSLs) of MoS2, where it finds that isolated flat moiré bands appear near the valence band edge, and they can be described by the honeycomb lattice ionic Hubbard model. More importantly, the hopping strength, the on‐site Coulomb repulsion, and the staggered potential in the TMSLs are highly tunable through the control of the twist angle, the dielectric environment, and the perpendicular electric field. It is possible to achieve various transitions between distinct quantum phases in the TMSLs, spanning from weak to strong correlation regimes. Therefore, the proposed TMSLs can serve as a good platform to study the strong correlation physics in the honeycomb lattice ionic Hubbard model. [ABSTRACT FROM AUTHOR]