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This study focuses on the common key technologies of "environmentally friendly and resource-saving" asphalt pavement. Reactive asphalt deodorizers react with volatile chemicals with irritating odors in asphalt under high temperature conditions, converting them into stable and non-volatile macromolecules to remove odors and achieve a deodorizing effect. A goal is to develop clean asphalt pavement materials with the main characteristics of "low consumption, low emissions, low pollution, high efficiency". In this experimental research, we used gas-emission detection devices and methods to detect and evaluate odor concentration, SO2, NO, volatile organic compounds, and other gases and volatile substances in the production and construction of clean asphalt and mixtures. By combining rheological experiments, mechanical experiments, and other means, this study investigates the effects of odor enhancers on the penetration, ductility, softening point, high-temperature rheological properties, construction, and workability of warm-mix asphalt and mixtures. Furthermore, infrared spectroscopy experiments are used to conduct in-depth research on the odor-enhancing mechanism of odor enhancers. The results indicate that the addition of odor enhancers has little effect on the penetration and softening point of asphalt and maintains the basic performance stability of asphalt. In terms of high-temperature rheological properties and construction workability, the addition of warm-mix agents has a significant impact on the high-temperature failure temperature and rotational viscosity of asphalt, while the influence of deodorizers is relatively small. At higher temperatures, the rotational viscosity increases with the increase in the amount of deodorant added. Functional group analysis shows that the newly added materials have little effect on the essential properties and chemical composition of asphalt. In addition, during the experimental process, it was found that the coupling effect and other chemical reactions between the deodorizing agent and the warm-mixing agent can effectively improve the degradation effect of harmful gases. After the coupling action of deodorant and the warm-mixing agent, the degradation rate of harmful gas can be increased by 5–20%, ensuring the stable performance of asphalt. The performance of powder deodorizing agent is better than that of liquid deodorizing agent, and an increase in the dosage of deodorizing agent will enhance the degradation effect. This study provides an important basis for a deeper understanding of the performance of warm-mix and odorless modified asphalt. [ABSTRACT FROM AUTHOR]

Conventional straight fin (SF) radiators have difficulties meeting the cooling requirements of high-power electronic components. Therefore, based on the structure and technology of the detachable fin radiator, this paper proposes a kind of radiator embedded in the heat pipe base and uses the roll-bond flat heat pipe (RBFHP) to replace the traditional fin. The radiator has the advantages of modularity, easy manufacturing, low cost and good heat balance. In this study, the heat pipes (HPs)-RBFHPs radiator was tested in natural convection and forced convection to mimic the actual application scenario and compared with the conventional aluminum radiator. Heating power, angle, wind speed and other aspects were studied. The results showed that the cooling performance of the HPs-RBFHPs radiator was improved by 10.7% to 55% compared with that of the SF radiator under different working conditions. The minimum total thermal resistance in the horizontal state was only 0.37 °C/W. The temperature equalization of the base played a dominant role in the performance of the radiator at a large angle, and the fin group could be ineffective when the angle was greater than 60°. Under the most economical conditions with an inclination of 0° and a wind speed of 2 m/s, the input power was 340 W, the heat source temperature of the HPs-RBFHPs was only 64.2 °C, and the heat dissipation performance was 55.4% higher than that of SFs. [ABSTRACT FROM AUTHOR]

Objective: Recent evidence suggests the involvement of senescence and inflammation in abdominal aortic aneurysm (AAA). Considering the role of sirtuin-1 (SIRT1) in delaying senescence, we aimed to preliminarily investigate the potential mechanism underlying the effects of SIRT1 in senescence and inflammation during AAA., Material and Methods: A cell AAA model was established using angiotensin II (Ang II) as the inducer, which was applied to treat human aortic vascular smooth muscle cells (HASMCs). The senescence and cell cycle of treated HASMCs were evaluated based on senescence-associated (SA)-b-galactosidase (b-gal) assay and flow cytometry, respectively. The levels of inflammatory cytokines and proteins related to senescence-associated secretory phenotype (SASP), along with nuclear factor-kappa B (NF-kB) and mitogen-activated protein kinases (MAPK) pathways, as well as SIRT1, were gauged. The correlation between SIRT1 and NF-kB and MAPK pathway-related proteins was further estimated., Results: In Ang II-treated HASMCs, reduced SIRT1 and B-cell lymphoma-2 levels yet increased levels of SASP-related proteins P16 and P21, inflammatory cytokines, as well as Bax and caspases were all visible. In the meantime, Ang II exposure enhanced the number of b-gal-positive HASMCs and promoted cell cycle arrest. SIRT1 was also repressed following Ang II treatment and negatively correlated with NF-kB and MAPK pathway-related proteins ( P < 0.05). Furthermore, the overexpression of SIRT1 diminished the levels of SASP-related proteins and reduced the phosphorylation of extracellular regulated kinase 1/2 and P65 in Ang II-treated HASMCs ( P < 0.05)., Conclusion: Taken together, our results indicate that SIRT1 overexpression attenuates the inflammatory and senescent responses of HASMCs in the Ang II-induced AAA cell model. This finding suggests that SIRT1 can be a highly promising target for clinical treatment of AAA., Competing Interests: The authors declare no conflict of interest, (© 2024 The Author(s). Published by Scientific Scholar.)

Rationale: Dissection of the cervical arteries is the most commonly identified cause of stroke in young patients. This report helps to investigate the etiology, diagnosis, and treatment of cervical artery dissection (CAD)., Patient Concerns: A 40-year-old female presented with a 3-week history of right carotid artery dissection due to a fall. The patient was admitted to the local hospital 3 weeks ago with a right neck impingement after a fall, and presented with right neck pain. The local hospital CT scan showed a dissection of the middle segment of the right common carotid artery., Diagnoses: The patient clinical manifestations and imaging tests confirmed that right carotid artery dissection., Interventions: Medical treatment with antiplatelet failed, and the CT scan showed progression of dissection. Carotid endarterectomy (CEA) was performed, and the prognosis is good., Outcomes: This patient was followed up at 1 and 6 months after the operation, CT scan showed the original stenotic vessels returned to standard diameter., Lessons: Diagnosis of CAD mainly depends on clinical manifestations and imaging. we recommend that clinicians can prescribe either anticoagulants or antiplatelet therapy. CAD can be effectively treated by surgical reconstruction, if medical treatment with anticoagulation or antiplatelet fails or if carotid aneurysms and/or high-grade carotid stenosis persisted or have newly developed., Competing Interests: The authors have no funding and conflicts of interest to disclose., (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)