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Abstract Long-term exposure to hyperglycemic conditions leads to β-cell dysfunction, particularly mitochondrial dysfunction, and inflammatory and oxidative stress responses, which are considered the primary causes of β-cell death and the hallmarks of diabetes. Plant-active ingredients may play a key role in glycemic control. Epigallocatechin gallate (EGCG) is a characteristic catechin derived from tea that possesses anti-diabetic properties. Nonetheless, its underlying mechanisms remain elusive. Herein, the protective role of EGCG on high glucose (33 mM)-induced pancreatic beta cell dysfunction and its possible molecular mechanisms were investigated. Briefly, MIN6 cells were treated with glucose and EGCG (10 µM, 20 µM, and 40 µM) for 48 h. Our results revealed that EGCG dose-dependently restored mitochondrial membrane potential and concomitantly alleviated cell apoptosis. Mechanistically, the expression level of apoptotic protein BAX and Dynamic related protein 1 (DRP1) was significantly downregulated following EGCG treatment, whereas that of the anti-apoptotic protein BCL-2 was significantly upregulated. Taken together, EGCG alleviated high glucose-induced pancreatic beta cell dysfunction by targeting the DRP1-related mitochondrial apoptosis pathway and thus can serve as a nutritional intervention for the preservation of beta cell dysfunction in patients with type 2 diabetes mellitus.

In this study, we designed ranging parameters and refined a loop filtering algorithm to solve the problem of parameter compatibility with the phasemeter and low ranging accuracy under bidirectional communication conditions. This enables the ranging and communication system to be integrated directly into the phasemeter as an auxiliary module. Experimental results compare fiber measurement lengths under different clock sources, indicating that the system achieves an ranging accuracy of 82.1 cm with an rms error of 9.14 cm. Additionally, the data communication rate reaches 19.5 kbps with a bit error rate below 10−6, all while ensuring that the implementation of the laser ranging and data communication system utilizes only 1% of the optical power to avoid introducing excessive phase noise to the scientific interferometer.

Time Delay Interferometry (TDI) is an indispensable step in the whole data processing procedure of space-based gravitational wave detection, as it mitigates the overwhelming laser frequency noise, which would otherwise completely bury the gravitational wave signals. Knowledge on the inter-spacecraft optical paths (i.e. delays) is one of the key elements of TDI. Conventional method for inter-spacecraft ranging mainly relies on the pseudo-random noise (PRN) code signal modulated onto the lasers. To ensure the reliability and robustness of this ranging information, it would be highly beneficial to develop other methods which could serve as cross-validations or backups. This paper explores the practical implementation of an alternative data-driven approach – time delay interferometry ranging (TDIR) – as a ranging technique independent of the PRN signal. Distinguished from previous research, our TDIR algorithm significantly relaxes the stringent requirement for clock synchronization imposed by traditional TDI procedure. By framing TDIR as a Bayesian parameter estimation problem and employing a general polynomial parametrization, we demonstrate our algorithm with simulated data based on the numerical orbit of Taiji. In the presence of laser frequency noise and secondary noises, the estimated median values of delays are only 5.28 ns away from the ground truths, capable of suppressing laser frequency noise to the desired level. Additionally, we have also analyzed the requirements of mitigating optical bench noise and clock noise on TDIR, and presented an illustrative example for the impact of laser locking.

Tilt-to-length (TTL) coupling noise arises from angular misalignments of interfering beams in optical path length (OPL) measurements and significantly impacts the accuracy of interferometry measurement systems. This paper focuses on geometric TTL coupling in a test mass (TM) interferometer and examines how an imaging system influences TTL noise suppression. First, the analytical expression of the geometric TTL coupling in a TM interferometer with alignment errors is derived and confirmed through numerical simulation. Subsequently, an imaging system is incorporated into the geometric model and the corresponding analytical expressions are obtained under two common conjugate relationships. Nevertheless, the TTL coupling remains beyond the requirement of TM interferometer, as the residual TTL coupled with alignment errors persists even with the imaging system. Therefore, an optimal position of the imaging system capable of eliminating the second-order term of the TTL coupling is determined. Meanwhile, the first-order term can be mitigated through in-orbit calibrations. These findings offer valuable guidance for the design and adjustment of imaging systems in space-borne gravitational wave detection missions, which require high-precision laser interferometry.