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Abstract The asymmetries of factors influencing the return of cryptocurrencies have already been well documented; however, in the case of NFTs, only information asymmetries and hedging properties related to asymmetries were studied. Therefore, the present study examines factors affecting NFT returns, from market-related factors (crypto-market index return and stock market index return) to the Amihud illiquidity ratio and Google search trends during different market conditions. The wavelet coherences-based methodology was applied separately during the boom, bust, normal, and turbulent periods identified by structural breakpoints. Based on 14 NFT projects between April 2019 and July 2022, results show two fundamental asymmetries influencing these NFT returns. First, there is an asymmetry in the behavior of the factors in different periods; second, there is an asymmetry in how illiquidity manifests itself over NFTs that do or do not possess cash flow-generating potential.

The rapid advancements in the field of genetics have significantly propelled the development of gene therapies, paving the way for innovative treatments of various hereditary disorders. This review focuses on the genetics of ophthalmologic conditions, highlighting the currently approved ophthalmic gene therapy and exploring emerging therapeutic strategies under development. Inherited retinal dystrophies represent a heterogeneous group of genetic disorders that manifest across a broad spectrum from infancy to late middle age. Key clinical features include nyctalopia (night blindness), constriction of the visual field, impairments in color perception, reduced central visual acuity, and rapid eye movements. Recent technological advancements, such as multimodal imaging, psychophysical assessments, and electrophysiological testing, have greatly enhanced our ability to understand disease progression and establish genotype-phenotype correlations.Additionally, the integration of molecular diagnostics into clinical practice is revolutionizing patient stratification and the design of targeted interventions, underscoring the transformative potential of personalized medicine in ophthalmology. The review also covers the challenges and opportunities in developing gene therapies for other ophthalmic conditions, such as age-related macular degeneration and optic neuropathies. We discuss the viral and non-viral vector systems used in ocular gene therapy, highlighting their advantages and limitations. Additionally, we explore the potential of emerging technologies like CRISPR/Cas9 in treating genetic eye diseases. We briefly address the regulatory landscape, concerns, challenges, and future directions of gene therapy in ophthalmology. We emphasize the need for long-term safety and efficacy data as these innovative treatments move from bench to bedside.