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The article discusses the role of Ephrin-B1 signaling in the self-renewal ability and recurrence of oral cancer cells. Through proteomic analysis, researchers found that Ephrin-B1 and EPHA2 play a critical role in enriching cancer stem cells. In vitro and in vivo studies confirmed the significance of Ephrin-B1-EPHA2 signaling in cancer cell self-renewal, with potential implications for prognosis and recurrence. The findings suggest that targeting this signaling pathway may offer new therapeutic strategies for oral cancer treatment. [Extracted from the article]

A recent study from the State University of Campinas (UNICAMP) in Brazil explores the role of Eph receptors and ephrins in upper digestive tract cancers. The research highlights the significance of these proteins in cancer development and progression, with potential implications for new anticancer therapies. The study emphasizes the importance of understanding the molecular mechanisms involved in these cancers to identify promising therapeutic targets. For more information, readers can access the full article in Frontiers in Oncology. [Extracted from the article]

Researchers at Guangdong Medical University conducted a study on the diagnostic value of serum Ephrin-A1 in patients with colorectal cancer. The study aimed to evaluate the performance of serum Ephrin-A1 in diagnosing colorectal cancer, using Enzyme-linked immunosorbent assay (ELISA) and receiver operating characteristic (ROC) analysis. Results showed that serum Ephrin-A1 levels were significantly higher in patients with colorectal cancer compared to healthy controls, indicating its potential as a biomarker for diagnosis. The research was supported by various funding sources and published in Scientific Reports. [Extracted from the article]

The article discusses the potential of Ephrin-A5 and EphA7 stimulation as anti-proliferative therapy for human rhabdomyosarcoma (RMS) in vitro. Current treatments for RMS are limited, emphasizing the need for alternative therapies like differentiation therapy, which aims to shift tumor cells from proliferating to differentiated states. The study found that while EphA7 had some effect, ephrin-A5 had a greater impact on RMS cell lines due to differences in Ephs and ephrins expressed by RMS cells. Further research into Eph:ephrin signaling as a potential differentiation therapy for RMS is warranted. [Extracted from the article]

Researchers from Kharazmi University conducted a study on the Nipah Virus, focusing on the interaction between small molecules and the virus glycoprotein in Malaysia and Bangladesh strains. The study aimed to identify potential drugs to inhibit viral transmission through human receptors Ephrin-B2 and Ephrin-B3. Computational simulations were used to evaluate seven drugs, with Pemirolast and Isoniazid Pyruvate identified as promising candidates. The research provides insights into potential treatments for the Nipah Virus and offers a strategy to address future viral variants. [Extracted from the article]

Researchers from Emory University School of Medicine conducted a study on urothelial cancer, focusing on the expression of Trop-2 and ephrin B2 in aggressive subtypes of the disease. The study analyzed 113 samples of urothelial carcinoma with divergent differentiation and aggressive subtype histology. The results indicated that Trop-2 expression was highest in certain subtypes like squamous cell carcinoma, while ephrin B2 expression was highest in adenocarcinoma and small cell carcinoma. The researchers suggested that these findings could lead to new therapeutic possibilities for patients with limited treatment options, particularly in small cell carcinoma. [Extracted from the article]