The proceedings of the 2nd International Conference on Next-Generation Computing and Information Systems (ICNGCIS'23) includes research papers in diverse emerging domains such as AI, blockchain, web 3.0, metaverse and edge computing apart from traditional domains such as distributed computing and networks and cybersecurity. The proceedings include papers addressing currently relevant research issues such as smart contract security, interoperability in the metaverse, AI applications in healthcare, agriculture and related domains. The proceedings encompass findings with real-world implications for the growth and evolution of modern computing and information systems by addressing various challenges related to their design, deployment, operational aspects, performance and shortcomings. The intended audience for the proceedings of ICNGCIS'23 include researchers from industry and academia, practitioners, students, technology enthusiasts and even general audience looking to explore interesting applications, use-cases and fundamental issues in modern computing and information systems.