1. Gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma (Carney Triad): natural history, adrenocortical component, and possible familial occurrence.
- Author
-
Carney JA
- Subjects
- Adolescent, Adult, Cause of Death, Child, Female, Follow-Up Studies, Humans, Male, Middle Aged, Adrenal Cortex Neoplasms diagnosis, Adrenal Cortex Neoplasms genetics, Adrenal Cortex Neoplasms therapy, Chondroma diagnosis, Chondroma genetics, Chondroma therapy, Lung Neoplasms diagnosis, Lung Neoplasms genetics, Lung Neoplasms therapy, Neoplasms, Multiple Primary diagnosis, Neoplasms, Multiple Primary genetics, Neoplasms, Multiple Primary therapy, Paraganglioma diagnosis, Paraganglioma genetics, Paraganglioma therapy, Sarcoma diagnosis, Sarcoma genetics, Sarcoma therapy, Stomach Neoplasms diagnosis, Stomach Neoplasms genetics, Stomach Neoplasms therapy
- Abstract
Objective: To investigate the natural history of the triad of gastric stromal sarcoma, pulmonary chondroma, and extra-adrenal paraganglioma, a rare syndrome of unknown cause primarily affecting young women., Methods: Mayo Clinic records, the world literature, and the author's files were searched for patients with all or 2 of the 3 tumors., Results: Seventy-nine patients, 67 women and 12 men, were identified, 17 (22%) with the 3 tumors and 62 (78%) with 2 tumors. Forty-two (53%) had gastric and pulmonary tumors, the most common combination. The longest interval between detection of the first and second components was 26 years (mean, 8.4 years; median, 6 years). Follow-up ranged from 1 year to 49 years (mean, 20.6 years; median, 20 years). Sixty-four patients (81%) were alive, 19 (24%) apparently free of disease and 45 (57%) with residual or metastatic tumors. Thirty-two patients (41%) had had 1 or more local recurrences of the gastric sarcoma; the longest interval to first recurrence was 36 years. Twenty-one survivors (27%) had hepatic metastatic gastric sarcoma with follow-up of 1 year to 25 years (mean, 9.3 years; median, 7 years). Fifteen patients (19%) were dead, 10 (13%) of whom died of the disorder. Ten patients (13%) had nonfunctioning adrenocortical tumors. Two patients each had a sibling with 1 component of the triad., Conclusions: The triad is a chronic, persistent, and indolent disease. Benign adrenocortical tumors are a component of the condition. The disorder may be familial.
- Published
- 1999
- Full Text
- View/download PDF