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29 results on '"Roubos, E.W."'

1. Targets and treatments for neuropathic pain: translational research from animals to humans

Author

Vissers, K.C.P., Roubos, E.W., Zundert, J. van, Kozicz, L.T., Vanelderen, P.J.L., Vissers, K.C.P., Roubos, E.W., Zundert, J. van, Kozicz, L.T., and Vanelderen, P.J.L.

Abstract

Radboud Universiteit Nijmegen, 11 november 2014, Promotores : Vissers, K.C.P., Roubos, E.W. Co-promotores : Zundert, J. van, Kozicz, L.T., Contains fulltext : 131646.pdf (publisher's version ) (Open Access)

Published
2014

2. Neuropathic pain and the brain. Differential involvement of corticotropin-releasing factor and urocortin 1 in acute and chronic pain processing

Author

Vissers, K.C.P., Roubos, E.W., Scheenen, W.J.J.M., Kozicz, L.T., Rouwette, T.P.H., Vissers, K.C.P., Roubos, E.W., Scheenen, W.J.J.M., Kozicz, L.T., and Rouwette, T.P.H.

Abstract

Radboud Universiteit Nijmegen, 22 juni 2012, Promotores : Vissers, K.C.P., Roubos, E.W. Co-promotores : Scheenen, W.J.J.M., Kozicz, L.T., Contains fulltext : 108820.pdf (Publisher’s version ) (Open Access)

Published
2012

3. Neuropathic pain and the brain. Differential involvement of corticotropin-releasing factor and urocortin 1 in acute and chronic pain processing

Author

Vissers, K.C.P., Roubos, E.W., Scheenen, W.J.J.M., Kozicz, L.T., Rouwette, T.P.H., Vissers, K.C.P., Roubos, E.W., Scheenen, W.J.J.M., Kozicz, L.T., and Rouwette, T.P.H.

Abstract

Radboud Universiteit Nijmegen, 22 juni 2012, Promotores : Vissers, K.C.P., Roubos, E.W. Co-promotores : Scheenen, W.J.J.M., Kozicz, L.T., Contains fulltext : 108820.pdf (Publisher’s version ) (Open Access)

Published
2012

5. The non-preganglionic Edinger-Westphal nucleus: an integration center for energy balance and stress adaption

Author

Roubos, E.W., Kozicz, L.T., Xu, L., Roubos, E.W., Kozicz, L.T., and Xu, L.

Abstract

Radboud Universiteit Nijmegen, 12 december 2011, Promotor : Roubos, E.W. Co-promotor : Kozicz, L.T., Contains fulltext : 91338.pdf (publisher's version ) (Open Access), The aim of this thesis research was to test our hypothesis that the non-preganglionic Edinger-Westphal nucleus (npEW) serves as an integrating center linking energy metabolism with stress adaptation. We have shown indeed that the npEW receives information about stress stimuli and the peripheral metabolic state. Moreover, it appears that not only the npEW as a whole responds to this information by changing its activity, but also that this reaction is a result of the differential reactions of the various neuropeptides expressed in this nucleus. Our results extend knowledge of the energy-dependent regulation of the stress adaptation response and, hopefully, will contribute to broadening insight into the etiology of stress-induced anxiety, depression and eating disorders, as well as may stimulate research to identify novel treatments to combat these disorders. In this respect, future studies on the mechanisms by which energy balance and leptin participate in the regulation of the npEW-Ucn1/CART system will be of particular interest.

Published
2011

9. Cellular and molecular aspects of Xenopus melanotrope cell functioning

Author

Roubos, E.W., Jenks, B.G., Corstens, G.J.H., Roubos, E.W., Jenks, B.G., and Corstens, G.J.H.

Abstract

RU Radboud Universiteit Nijmegen, 03 februari 2006, Promotor : Roubos, E.W. Co-promotor : Jenks, B.G., Contains fulltext : 36216.pdf (Publisher’s version ) (Open Access)

Published
2006

10. Characterization and regulation of voltage-operated ca2+ channels in neuroendocrine melanotrope cells of

Author

Roubos, E.W., Scheenen, W.J.J.M., Zhang, H.Y., Roubos, E.W., Scheenen, W.J.J.M., and Zhang, H.Y.

Abstract

RU Radboud Universiteit Nijmegen, 04 juli 2006, Promotor : Roubos, E.W. Co-promotor : Scheenen, W.J.J.M., Contains fulltext : 27463.pdf (publisher's version ) (Open Access), To investigate the way by which multiple incoming neurochemical messengers control second messenger systems to evoke an unambiguous neuronal output, melanotrope neuroendocrine cells in the pars intermedia of the pituitary gland of the South African clawed toad Xenopus laevis were studied. Researches in this thesis reveal: 1) Black-adapted melanotropes express all classes of high-voltage activated (HVA) Ca2+ channels, namely the L, N, P/Q and R types, but no low-voltage-activated (LVA) Ca2+ channels. 2) The N-type and R-type channels are involved in the generation of spontaneous intracellular Ca2+ oscillations. 3) The three GiPCRs inhibit the R-type Ca2+ currents through G / subunits. 4) Activation of the DA-D2 and the NPY-Y1 receptor inhibit the N-type Ca2+ current through another, as yet unidentified mechanism. These receptors inhibit this calcium current with similar strength as they inhibit MSH secretion. 5) Synergy between the two stimulatory neuropeptides TRH and sauvagine reverses D2-receptor-induced inhibition of spontaneous Ca2+ oscillations and action current firing, whereas the individual stimulatory peptides are ineffective. The combination of TRH and sauvagine cannot reverse the D2-receptor-induced inhibition of the R- and N-type Ca2+ currents, and as a result also do not reverse the inhibition of hormone secretion. The results also indicate that the Xenopus melanotrope can generate Ca2+ oscillations that are independent of Ca2+ influx through R- and N-type Ca2+ channels. 6) Ca2+-dependent regulation of Ca2+ currents is correlated with adaptation to background light intensity: in melanotropes from white-adapted toads, Ca2+-dependent regulation of L-type Ca2+ channels is more dominant than in black-adapted melanotropes. 7) In contrast to black-adapted melanotropes, white-adapted melanotropes express LVA Ca2+ channels. In conclusion, the experiments described in this thesis have revealed some important features of the melanotrope cell and have provided new

Published
2006

11. Cellular and molecular aspects of Xenopus melanotrope cell functioning

Author

Roubos, E.W., Jenks, B.G., Corstens, G.J.H., Roubos, E.W., Jenks, B.G., and Corstens, G.J.H.

Abstract

RU Radboud Universiteit Nijmegen, 03 februari 2006, Promotor : Roubos, E.W. Co-promotor : Jenks, B.G., Contains fulltext : 36216.pdf (Publisher’s version ) (Open Access)

Published
2006

12. Integrative Physiology and Communication in the Amphibian Brain

Author

Roubos, E.W., Barendregt, H.P., Veening, J.G., Calle, M., Roubos, E.W., Barendregt, H.P., Veening, J.G., and Calle, M.

Abstract

RU Radboud Universiteit Nijmegen, 02 november 2006, Promotores : Roubos, E.W., Barendregt, H.P. Co-promotor : Veening, J.G., Contains fulltext : 29821.pdf (publisher's version ) (Open Access)

Published
2006

13. Integrative Physiology and Communication in the Amphibian Brain

Author

Roubos, E.W., Barendregt, H.P., Veening, J.G., Calle, M., Roubos, E.W., Barendregt, H.P., Veening, J.G., and Calle, M.

Abstract

RU Radboud Universiteit Nijmegen, 02 november 2006, Promotores : Roubos, E.W., Barendregt, H.P. Co-promotor : Veening, J.G., Contains fulltext : 29821.pdf (publisher's version ) (Open Access)

Published
2006

14. Cellular and molecular aspects of Xenopus melanotrope cell functioning

Author

Roubos, E.W., Jenks, B.G., Corstens, G.J.H., Roubos, E.W., Jenks, B.G., and Corstens, G.J.H.

Abstract

RU Radboud Universiteit Nijmegen, 03 februari 2006, Promotor : Roubos, E.W. Co-promotor : Jenks, B.G., Contains fulltext : 36216.pdf (Publisher’s version ) (Open Access)

Published
2006

15. Characterization and regulation of voltage-operated ca2+ channels in neuroendocrine melanotrope cells of

Author

Roubos, E.W., Scheenen, W.J.J.M., Zhang, H.Y., Roubos, E.W., Scheenen, W.J.J.M., and Zhang, H.Y.

Abstract

RU Radboud Universiteit Nijmegen, 04 juli 2006, Promotor : Roubos, E.W. Co-promotor : Scheenen, W.J.J.M., Contains fulltext : 27463.pdf (publisher's version ) (Open Access), To investigate the way by which multiple incoming neurochemical messengers control second messenger systems to evoke an unambiguous neuronal output, melanotrope neuroendocrine cells in the pars intermedia of the pituitary gland of the South African clawed toad Xenopus laevis were studied. Researches in this thesis reveal: 1) Black-adapted melanotropes express all classes of high-voltage activated (HVA) Ca2+ channels, namely the L, N, P/Q and R types, but no low-voltage-activated (LVA) Ca2+ channels. 2) The N-type and R-type channels are involved in the generation of spontaneous intracellular Ca2+ oscillations. 3) The three GiPCRs inhibit the R-type Ca2+ currents through G / subunits. 4) Activation of the DA-D2 and the NPY-Y1 receptor inhibit the N-type Ca2+ current through another, as yet unidentified mechanism. These receptors inhibit this calcium current with similar strength as they inhibit MSH secretion. 5) Synergy between the two stimulatory neuropeptides TRH and sauvagine reverses D2-receptor-induced inhibition of spontaneous Ca2+ oscillations and action current firing, whereas the individual stimulatory peptides are ineffective. The combination of TRH and sauvagine cannot reverse the D2-receptor-induced inhibition of the R- and N-type Ca2+ currents, and as a result also do not reverse the inhibition of hormone secretion. The results also indicate that the Xenopus melanotrope can generate Ca2+ oscillations that are independent of Ca2+ influx through R- and N-type Ca2+ channels. 6) Ca2+-dependent regulation of Ca2+ currents is correlated with adaptation to background light intensity: in melanotropes from white-adapted toads, Ca2+-dependent regulation of L-type Ca2+ channels is more dominant than in black-adapted melanotropes. 7) In contrast to black-adapted melanotropes, white-adapted melanotropes express LVA Ca2+ channels. In conclusion, the experiments described in this thesis have revealed some important features of the melanotrope cell and have provided new

Published
2006

16. The extracellular calcium-sensing receptor in pituitary melanotrope cells

Author

Roubos, E.W., Jenks, B.G., Hurk, M.J.J. van den, Roubos, E.W., Jenks, B.G., and Hurk, M.J.J. van den

Abstract

RU Radboud Universiteit Nijmegen, 19 december 2005, Promotor : Roubos, E.W. Co-promotor : Jenks, B.G., Contains fulltext : 33185.pdf (Publisher’s version ) (Open Access)

Published
2005

17. The extracellular calcium-sensing receptor in pituitary melanotrope cells

Author

Roubos, E.W., Jenks, B.G., Hurk, M.J.J. van den, Roubos, E.W., Jenks, B.G., and Hurk, M.J.J. van den

Abstract

RU Radboud Universiteit Nijmegen, 19 december 2005, Promotor : Roubos, E.W. Co-promotor : Jenks, B.G., Contains fulltext : 33185.pdf (Publisher’s version ) (Open Access)

Published
2005

18. The extracellular calcium-sensing receptor in pituitary melanotrope cells

Author

Roubos, E.W., Jenks, B.G., Hurk, M.J.J. van den, Roubos, E.W., Jenks, B.G., and Hurk, M.J.J. van den

Abstract

RU Radboud Universiteit Nijmegen, 19 december 2005, Promotor : Roubos, E.W. Co-promotor : Jenks, B.G., Contains fulltext : 33185.pdf (Publisher’s version ) (Open Access)

Published
2005

19. The extracellular calcium-sensing receptor in pituitary melanotrope cells

Author

Roubos, E.W., Jenks, B.G., Hurk, M.J.J. van den, Roubos, E.W., Jenks, B.G., and Hurk, M.J.J. van den

Abstract

RU Radboud Universiteit Nijmegen, 19 december 2005, Promotor : Roubos, E.W. Co-promotor : Jenks, B.G., Contains fulltext : 33185.pdf (Publisher’s version ) (Open Access)

Published
2005

20. Cellular and Molecular Determinants Underlying Spike-Wave Discharge Initiation and Maintenance in the Absence Epileptic WAG/Rij Rat

Author

Roubos, E.W., Scheenen, W.J.J.M., Luijtelaar, E.L.J.M. van, Bovenkamp-Janssen, M.C. van de, Roubos, E.W., Scheenen, W.J.J.M., Luijtelaar, E.L.J.M. van, and Bovenkamp-Janssen, M.C. van de

Abstract

RU Radboud Universiteit Nijmegen, 17 maart 2004, Promotor : Roubos, E.W. Co-promotores : Scheenen, W.J.J.M., Luijtelaar, E.L.J.M. van, Item does not contain fulltext

Published
2004

21. Excitability and Calcium Signaling. A comparative study on Xenopus laevis melanotrope cells and normal rat kidney fibroblasts

Author

Gielen, C.C.A.M., Roubos, E.W., Ypey, D.L., Scheenen, W.J.J.M., Cornelisse, L.N., Gielen, C.C.A.M., Roubos, E.W., Ypey, D.L., Scheenen, W.J.J.M., and Cornelisse, L.N.

Abstract

RU Radboud Universiteit Nijmegen, 16 april 2004, Promotores : Gielen, C.C.A.M., Roubos, E.W., Ypey, D.L. Co-promotor : Scheenen, W.J.J.M., Contains fulltext : 19428_exciancas.pdf (publisher's version ) (Open Access)

Published
2004

23. Cellular and molecular determinants underlying spike-wave discharge initiation and maintenance in the absence epileptic WAG/RIJ RAT

Author

Roubos, E.W., Scheenen, W.J.J.M., Luijtelaar, E.L.J.M. van, Bovenkamp-Janssen, M.C. van de, Roubos, E.W., Scheenen, W.J.J.M., Luijtelaar, E.L.J.M. van, and Bovenkamp-Janssen, M.C. van de

Abstract

RU Radboud Universiteit Nijmegen, 17 maart 2004, Promotor : Roubos, E.W. Co-promotores : Scheenen, W.J.J.M., Luijtelaar, E.L.J.M. van, Contains fulltext : 64354.pdf (publisher's version ) (Open Access)

Published
2004

24. Excitability and Calcium Signaling. A comparative study on Xenopus laevis melanotrope cells and normal rat kidney fibroblasts

Author

Gielen, C.C.A.M., Roubos, E.W., Ypey, D.L., Scheenen, W.J.J.M., Cornelisse, L.N., Gielen, C.C.A.M., Roubos, E.W., Ypey, D.L., Scheenen, W.J.J.M., and Cornelisse, L.N.

Abstract

RU Radboud Universiteit Nijmegen, 16 april 2004, Promotores : Gielen, C.C.A.M., Roubos, E.W., Ypey, D.L. Co-promotor : Scheenen, W.J.J.M., Contains fulltext : 19428_exciancas.pdf (publisher's version ) (Open Access)

Published
2004

25. Cellular and Molecular Determinants Underlying Spike-Wave Discharge Initiation and Maintenance in the Absence Epileptic WAG/Rij Rat

Author

Roubos, E.W., Scheenen, W.J.J.M., Luijtelaar, E.L.J.M. van, Bovenkamp-Janssen, M.C. van de, Roubos, E.W., Scheenen, W.J.J.M., Luijtelaar, E.L.J.M. van, and Bovenkamp-Janssen, M.C. van de

Abstract

RU Radboud Universiteit Nijmegen, 17 maart 2004, Promotor : Roubos, E.W. Co-promotores : Scheenen, W.J.J.M., Luijtelaar, E.L.J.M. van, Item does not contain fulltext

Published
2004

27. Cellular and molecular determinants underlying spike-wave discharge initiation and maintenance in the absence epileptic WAG/RIJ RAT

Author

Roubos, E.W., Scheenen, W.J.J.M., Luijtelaar, E.L.J.M. van, Bovenkamp-Janssen, M.C. van de, Roubos, E.W., Scheenen, W.J.J.M., Luijtelaar, E.L.J.M. van, and Bovenkamp-Janssen, M.C. van de

Abstract

RU Radboud Universiteit Nijmegen, 17 maart 2004, Promotor : Roubos, E.W. Co-promotores : Scheenen, W.J.J.M., Luijtelaar, E.L.J.M. van, Contains fulltext : 64354.pdf (publisher's version ) (Open Access)

Published
2004

28. Excitability and Calcium Signaling. A comparative study on Xenopus laevis melanotrope cells and normal rat kidney fibroblasts

Author

Gielen, C.C.A.M., Roubos, E.W., Ypey, D.L., Scheenen, W.J.J.M., Cornelisse, L.N., Gielen, C.C.A.M., Roubos, E.W., Ypey, D.L., Scheenen, W.J.J.M., and Cornelisse, L.N.

Abstract

RU Radboud Universiteit Nijmegen, 16 april 2004, Promotores : Gielen, C.C.A.M., Roubos, E.W., Ypey, D.L. Co-promotor : Scheenen, W.J.J.M., Contains fulltext : 19428_exciancas.pdf (publisher's version ) (Open Access)

Published
2004

29. Cellular and Molecular Determinants Underlying Spike-Wave Discharge Initiation and Maintenance in the Absence Epileptic WAG/Rij Rat

Author

Roubos, E.W., Scheenen, W.J.J.M., Luijtelaar, E.L.J.M. van, Bovenkamp-Janssen, M.C. van de, Roubos, E.W., Scheenen, W.J.J.M., Luijtelaar, E.L.J.M. van, and Bovenkamp-Janssen, M.C. van de

Abstract

RU Radboud Universiteit Nijmegen, 17 maart 2004, Promotor : Roubos, E.W. Co-promotores : Scheenen, W.J.J.M., Luijtelaar, E.L.J.M. van, Item does not contain fulltext

Published
2004

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