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混合ハーブ抽出物(MHE)は抗糖化作用が既に報告されている。HMEはローマカミツレ・セイヨウサンザシ・ドクダミ・ブドウ葉の熱水抽出物である。HMEは漢方薬とみなすことができる。漢方薬では、構成生薬の追加が元の効能を変化させることが知られている。HMEに生薬である生姜・山椒を加えカプセルに充填した試験食を作成し、それが抗糖化作用を示すか調べた。またQOLへの影響を調べた。対象者は12名で、血糖正常群8名(男:女1:7、平均年齢47歳)と糖尿病・高血糖群4名(男:女3:1、平均年齢51歳、HbA1c 5.7～7.0)の2群に分けられた。両群とも、HMEはエキス固形分240mgと生姜・山椒一定量を1日量として4カプセル・12週間摂取した。また各群の1名ずつは80週間摂取を継続した。抗糖化作用は皮膚AGEs蓄積を非侵襲的に測定し皮膚自発蛍光(AF)として示すAGE reader™により評価した。皮膚弾力はCutometerにより評価した。 抗加齢QOL共通問診表により「便秘」、「冷え性」、「体重減少」が有意(p=0.043)の改善または変化を認めた。皮膚AFは8週・12週にて両群とも減少し、血糖正常群では12週で有意(p=0.020)な低下を認めた。80週までの継続摂取では皮膚AF減少は継続した。12週での摂取終了は皮膚AFの悪化を認めた。皮膚弾力は糖尿病・高血糖群の12週でR2に若干の改善を認めた。MHEに2つの生薬を追加配合した処方は皮膚AGEs蓄積を抑制した。試験食の継続摂取は安全で有用な抗糖化法と考えられることが示唆された。, The anti-glycation effect of mixed herbal extract (MHE) was already reported. HME was produced using hot water extraction from Anthemis nobilis (Roman chamomile), Crataegus oxyacantha (hawthorn berry), Houttuynia cordata (dokudami), and Vitis vinifera (grape leaf). MHE can be regarded as a Chinese herbal remedy. In Chinese herbal remedy, it is well known that a little of additional crude drugs can change the original effects. We assessed whether a capsulated novel remedy of MHE with Zingiber officinale (syouga) and Zanthoxylum piperitum (sansho) showed an anti-glycation effect. We also assessed its effects on one's quality of life (QOL). The subjects consisted of 12 volunteers divided into two groups, the Normal Blood Sugar (NBS) Group (male: 1; female: 7; age: 47.3 ± 10.2 years) and the Diabetes Mellitus / Impaired Fasting Glycaemia (DM/IFG) Group (male: 3; female: 1; age: 51.5 ± 12.7 years) with HbA1c 5.7～7.0. Both of the Groups were administered 240 mg of MHE (solid substance) with certain amounts of Zingiber officinale (syouga) and Zanthoxylum piperitum (sansyo) in 4 capsules per day for 12 weeks. Two individuals - one of NBS Group and the other of DM/IFG Group - were administered continuously for 80 weeks. The inhibition of glycation was assessed by AGE reader™, non-invasively measuring the advanced glycation endproducts (AGEs) as skin auto fluorescence (AF). Also the skin elasticity was assessed by Cutometer. The analysis using the Anti-Aging QOL Common Questionnaire (AAQol) showed that the score for the parameters, “constipation", “cold skin", and “weight loss; thin" were significantly improved or changed (p=0.043). The skin AF decreased in the both Groups after 8 and 12 weeks respectively, and significant variation (p=0.020) was observed in the NBS Group after 12 weeks. Continuous intake for 80 weeks revealed continuing low values of skin AF. Stopping the intake at 12 weeks resulted in a deterioration of skin AF. The skin elasticity index R2 in the DM/IFG Group showed a slight improving tendency after 12 weeks. The novel remedy of MHE with additional two crude drugs inhibited the accumulation of AGEs in the skin. These results suggest that a continuous supplementation of the test product was considered to be a safe anti-glycation method.