1. EEG for good outcome prediction after cardiac arrest: A multicentre cohort study
- Author
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Turella, S., Dankiewicz, J., Ben-Hamouda, N., Nilsen, Kb, During, J., Endisch, C., Engstrom, M., Flugel, D., Gaspard, N., Grejs, A. M., Haenggi, M., Haffey, S., Imbach, L., Johnsen, B., Kemlink, D., Leithner, C., Legriel, S., Lindehammar, Hans, Mazzon, G., Nielsen, N., Peyre, A., Stanford, B. Ribalta, Roman-Pognuz, E., Rossetti, A. O., Schrag, C., Valerianova, A., Wendel-Garcia, P., Zubler, F., Cronberg, T., Westhall, E., Turella, S., Dankiewicz, J., Ben-Hamouda, N., Nilsen, Kb, During, J., Endisch, C., Engstrom, M., Flugel, D., Gaspard, N., Grejs, A. M., Haenggi, M., Haffey, S., Imbach, L., Johnsen, B., Kemlink, D., Leithner, C., Legriel, S., Lindehammar, Hans, Mazzon, G., Nielsen, N., Peyre, A., Stanford, B. Ribalta, Roman-Pognuz, E., Rossetti, A. O., Schrag, C., Valerianova, A., Wendel-Garcia, P., Zubler, F., Cronberg, T., and Westhall, E.
- Abstract
Aim: Assess the prognostic ability of a non-highly malignant and reactive EEG to predict good outcome after cardiac arrest (CA). Methods: Prospective observational multicentre substudy of the "Targeted Hypothermia versus Targeted Normothermia after Out-of-hospital Cardiac Arrest Trial", also known as the TTM2-trial. Presence or absence of highly malignant EEG patterns and EEG reactivity to external stimuli were prospectively assessed and reported by the trial sites. Highly malignant patterns were defined as burst-suppression or suppression with or without superimposed periodic discharges. Multimodal prognostication was performed 96 h after CA. Good outcome at 6 months was defined as a modified Rankin Scale score of 0-3. Results: 873 comatose patients at 59 sites had an EEG assessment during the hospital stay. Of these, 283 (32%) had good outcome. EEG was recorded at a median of 69 h (IQR 47-91) after CA. Absence of highly malignant EEG patterns was seen in 543 patients of whom 255 (29% of the cohort) had preserved EEG reactivity. A non-highly malignant and reactive EEG had 56% (CI 50-61) sensitivity and 83% (CI 80-86) specificity to predict good outcome. Presence of EEG reactivity contributed (p < 0.001) to the specificity of EEG to predict good outcome compared to only assessing background pattern without taking reactivity into account. Conclusion: Nearly one-third of comatose patients resuscitated after CA had a non-highly malignant and reactive EEG that was associated with a good long-term outcome. Reactivity testing should be routinely performed since preserved EEG reactivity contributed to prognostic performance., Funding Agencies|Swedish Research Council; Swedish Heart-Lung Foundation; Knutsson Foundation, Laerdal Foundation; (Hans-Gabriel and Alice Trolle-Wachtmeister Foundation for Medical Research, and Regional Research Support in Region Skane); Laerdal Foundation; Hans-Gabriel and Alice Trolle-Wachtmeister Foundation for Medical Research; Regional Research Support in Region Skane; Swedish National Health Service
- Published
- 2024
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