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The most common malignant eyelid tumors are basal cell carcinoma and squamous cell carcinoma. The study enrolled 28 patients (28 eyes) (8 men and 20 women) (mean age 74.1 ± 7.6 years). The postoperative follow-up was 23.3 ± 9.8 months. The objective of this investigation was to study the results of plastic surgery using flaps for extensive eyelid defects after removal of malignant epithelial eyelid neoplasms. The presented results of full-thickness resection of malignant epithelial eyelid neoplasms with single-stage flap reconstruction of extensive defects of the eyelid demonstrate good functional and cosmetic rehabilitation in the patients.