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Start Over Descriptor "meio de contraste" Publisher academia brasileira de ciencias
2 results on '"meio de contraste"'

1. Evaluation of the mutagenic effect of the iodinated contrast medium Urografina® 292 using the micronucleus test in mouse bone marrow cells

Author

MÔNICA B.B. BELLE, DANIELA D. LEFFA, DALIANE MAZZORANA, and VANESSA M. DE ANDRADE

Subjects
cromossomos, meio de contraste, micronúcleos, Urografina® 292, chromosomes, contrast medium, micronuclei, Science
Abstract

Contrast media (CM) are frequently used in diagnostic radiology and in radiotherapy as a diagnostic tool and in treatment planning. Previous studies have demonstrated that these compounds induce chromosomal aberrations. This study evaluates the mutagenic effects induced by the contrast medium Urografina® 292 (meglumine amidotrizoate and sodium-ionic dimmer) in bone marrow cells (BMC) of mice in vivo. Micronuclei assay was performed in BMC of CF-1 mice injected with CM 1.5 and 3.0 mL/kg intravenous doses and 1.0, 2.0, 3.0 mL/kg intraperitoneal doses. The animals were beheaded 24 h after treatment by cervical dislocation, and femur BMC from each animal were used in the micronucleus test. The group treated with the highest intravenous injection of Urografina® 292 (3.0 mL/kg) presented an increase in the frequency of micronucleated polychromatic erythrocytes (MNPCEs) in relation at the control group (P® 292 may cause a significant increase of cytogenetic damage in bone marrow cells of mice.Meios de contraste (MC) são freqüentemente utilizados em radiodiagnóstico e em radioterapia como uma ferramenta de diagnóstico e em planejamento do tratamento. Estudos prévios demonstraram que estes compostos induzem aberrações cromossômicas. Este estudo avaliou os efeitos mutagênicos induzidos pelo meio de contraste Urografina® 292 (Amidotrizoate de meglumina e sódio-dímero iônico) em células da medula óssea (BMC) de camundongos in vivo. Teste de micronúcleos foi realizado em BMC de camundongos CF-1, injetados com MC intravenoso nas doses 1,5 e 3,0 mL/kg e intraperitonealmente nas doses 1,0, 2,0 e 3,0 mL/kg. Os animais foram decapitados 24 horas após o tratamento por deslocamento cervical, e as BMC dos fêmures de cada animal foram utilizados no teste de micronúcleos. O grupo tratado com injeção intravenosa mais elevada de Urografina® 292 (3,0 mL/kg) apresentou um aumento na freqüência de eritrócitos policromáticos micronucleados (MNPCEs) em relação ao grupo controle (P® 292 pode causar um aumento significativo de danos citogenéticos em células da medula óssea de camundongos.

Published
2013

2. Evaluation of the mutagenic effect of the iodinated contrast medium Urografina® 292 using the micronucleus test in mouse bone marrow cells

Author

Daliane Mazzorana, Mônica B.B. Belle, Vanessa Moraes de Andrade, and Daniela Dimer Leffa

Subjects
Male, Pathology, medicine.medical_specialty, chromosomes, Contrast Media, Bone Marrow Cells, Mice, Inbred Strains, Urografina® 292, Andrology, Mice, contrast medium, Iodinated contrast, In vivo, Medicine, Animals, Femur, micronucleos, Diatrizoate Meglumine, Chromosome Aberrations, Multidisciplinary, Micronucleus Tests, Dose-Response Relationship, Drug, business.industry, meio de contraste, Contrast medium, Dose–response relationship, medicine.anatomical_structure, micronuclei, Micronucleus test, cromossomos, Bone marrow, business
Abstract

Contrast media (CM) are frequently used in diagnostic radiology and in radiotherapy as a diagnostic tool and in treatment planning. Previous studies have demonstrated that these compounds induce chromosomal aberrations. This study evaluates the mutagenic effects induced by the contrast medium Urografina® 292 (meglumine amidotrizoate and sodium-ionic dimmer) in bone marrow cells (BMC) of mice in vivo. Micronuclei assay was performed in BMC of CF-1 mice injected with CM 1.5 and 3.0 mL/kg intravenous doses and 1.0, 2.0, 3.0 mL/kg intraperitoneal doses. The animals were beheaded 24 h after treatment by cervical dislocation, and femur BMC from each animal were used in the micronucleus test. The group treated with the highest intravenous injection of Urografina® 292 (3.0 mL/kg) presented an increase in the frequency of micronucleated polychromatic erythrocytes (MNPCEs) in relation at the control group (P

Published
2013

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