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Burns are the most damaging kind of injuries, major global public health crisis and the fourth most common types of trauma. Decision making in the treatment of burns remains a challenge despite existence of improved assessment techniques and treatment procedures. One of the most complications in healing of burn tissues is necrosis. Several medicinal plants were used to treat skin disorders as burn wounds and necrosis so far. In our traditional medicine, one of the non-surgical methods for debridement of necrotic tissues is using toasted barley in sesame oil. Animal was used, because of the lack of previous scientific research about this herbal mixture for debridement of necrotic tissue. After being anesthetized, the second-degree burns were created in rats. Animals were divided into group I, not treated (control group) and group II treated with fibrinolysin ointment 3% (positive control group). Groups III, IV and V were treated with 1, 3 and 5% w/w doses of toasted barley in sesame oil, respectively. Histopathological and clinical findings showed that treated tissues, especially at dose of 5% w/w were more debrided. Therefore, with respect to our results, this herbal based compound can be used as remedy for debridement of necrotic tissue. Key words: Burn, debridement, necrosis, sesame oil, toasted barley.