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Your search keyword '"Arrestin physiology"' showing total 2 results
Start Over Descriptor "Arrestin physiology" Publisher academic press
2 results on '"Arrestin physiology"'

1. Characterization of arrestin expression and function.

Author

Mundell SJ, Orsini MJ, and Benovic JL

Subjects
Amino Acid Sequence, Animals, Antibodies chemistry, Arrestin genetics, Arrestin immunology, Arrestin physiology, Base Sequence, Blotting, Western, Cell Line, DNA Primers, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Humans, Transfection, Arrestin metabolism
Published
2002
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2. Circadian aqueous flow mediated by beta-arrestin induced homologous desensitization.

Author

Wan XL, Sears J, Chen S, and Sears M

Subjects
Amino Acid Sequence, Animals, Arrestin genetics, Arrestin physiology, Blotting, Northern, Blotting, Western, Ciliary Body metabolism, Epithelium metabolism, Fluorescent Antibody Technique, Indirect, Gene Expression Regulation, Male, Molecular Sequence Data, RNA, Messenger genetics, Rabbits, Species Specificity, Aqueous Humor physiology, Arrestin metabolism, Circadian Rhythm physiology
Abstract

It was hypothesized that homologous desensitization regulates signal transduction from the beta-adrenergic receptor in the ocular ciliary epithelium to affect the circadian rhythm of aqueous humor secretion. beta-arrestin-1 was cloned from the rabbit ciliary epithelium, and the full length cDNA used as a probe for Northern blot analysis to examine the diurnal expression of beta-arrestin mRNA. Protein expression of beta-arrestin-1 at intervals during the circadian cycle of aqueous secretion showed a decrease in beta-arrestin expression when maximal activation of the beta-adrenergic receptor is known to increase secretion. Diurnal expression of beta-arrestin suggests that homologous desensitization can regulate the circadian rhythm of aqueous flow.

Published
1997
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