1. DSP-4 treatment accelerates kindling.
- Author
-
Carre G and Harley C
- Subjects
- Action Potentials drug effects, Amygdala drug effects, Animals, Male, Rats, Rats, Inbred Strains, Telencephalon metabolism, Benzylamines pharmacology, Kindling, Neurologic drug effects, Norepinephrine metabolism, Telencephalon drug effects
- Abstract
Norepinephrine depletion of the central nervous system by peripheral N-(2-chloroethyl)-N-ethyl bromobenzylamine administration accelerates the development of seizures kindled by repeated stimulation of the amygdala. These data, in conjunction with previous 6-hydroxydopamine data, demonstrate the robustness of this phenomenon and emphasize the importance of noradrenergic innervation originating from the locus ceruleus in the suppression of seizure development.
- Published
- 1986
- Full Text
- View/download PDF