1. Proteomics methods for discovering viral-host interactions.
- Author
-
Georges AA and Frappier L
- Subjects
- Mass Spectrometry methods, Viral Proteins isolation & purification, Host-Pathogen Interactions, Proteomics methods, Viral Proteins chemistry
- Abstract
The functions of many viral proteins involve direct interactions with specific host proteins. Therefore considerable insight into the functions of a viral protein and its mechanisms of action can come from applying proteomics approaches to viral proteins in order to identify their cellular binding partners. In this chapter we describe proteomics approaches that have proven to be the most useful in identifying host interactions of viral proteins in human cells. Caveats and potential alternatives for each step are also discussed., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
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