1. Disease progression due to dual infection in an HLA-B57-positive asymptomatic long-term nonprogressor infected with a nef-defective HIV-1 strain.
- Author
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Braibant M, Xie J, Samri A, Agut H, Autran B, and Barin F
- Subjects
- Amino Acid Sequence, Base Sequence, Gene Expression Regulation physiology, HLA-B Antigens genetics, Humans, Male, Middle Aged, Molecular Sequence Data, Phylogeny, Time Factors, nef Gene Products, Human Immunodeficiency Virus chemistry, nef Gene Products, Human Immunodeficiency Virus metabolism, HIV Infections virology, HIV Long-Term Survivors, HIV-1 genetics, HLA-B Antigens metabolism, Superinfection virology, nef Gene Products, Human Immunodeficiency Virus genetics
- Abstract
We describe the case of an HLA-B57-positive long-term nonprogressor in whom we previously showed that PBMCs accumulated HIV-1 subtype B proviruses defective in the env gene. After more than 10 years of control of infection, plasma viremia increased progressively, with a concomitant loss of CD4(+) T cells. By phylogenetic analyses of env, nef, vif, and gag sequences obtained at different time points, we suggest here that this patient was initially infected by a putatively attenuated nef-defective variant and that loss of control was due to superinfection with a fully competent virus belonging to the same clade B. At the time of superinfection, its plasma was unable to efficiently neutralize the superinfecting virus and moderate Gag-specific CD8(+) T-cell responses were observed. This suggests the limited capacity of even a long-lasting natural infection with a nef-deficient HIV-1 strain to elicit immune responses able to prevent and control superinfection with a virus of the same clade., (Copyright 2010 Elsevier Inc. All rights reserved.)
- Published
- 2010
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